dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000149
Uniprot Accession O00712; NFIB_HUMAN; G3V1P1; H7BYE8; O00166; Q12858; Q5VW29; Q63HM5; Q6ZNF9; Q96J45;
Genbank Protein ID NP_001177666.1; NP_001177667.1; NP_001269716.1; NP_005587.2;
Genbank Nucleotide ID NM_001190737.1; NM_001190738.1; NM_001282787.1; NM_005596.3;
Protein Name Nuclear factor 1 B-type
Protein Synonyms/Alias
Gene Name NFIB
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Phosphorylation Sites
 dbPAF PTMs: 39 (View all)
PositionPeptidesSourceReferences ( PMIDs )
3-----MMYSPICLTQdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
4----MMYSPICLTQDcurated22199227; 20068231
41LQARKRKYFKKHEKRdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
50KKHEKRMSKDEERAVdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298
63AVKDELLSEKPEIKQdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 19060867; 22135298
192QEQDSGQSGSPSHNDcurated25627689
194QDSGQSGSPSHNDPAPhosphoSitePlus;curated22135298; 25627689
196SGQSGSPSHNDPAKNPhosphoSitePlus22135298
207PAKNPPGYLEDSFVKPhosphoSitePlus22135298
211PPGYLEDSFVKSGVFPhosphoSitePlus;curated22135298; 25627689; 23186163
221KSGVFNVSELVRVSRPhosphoSitePlus;curated22135298; 25627689
229ELVRVSRTPITQGTGcurated25627689
262SGVNLQRSLSSPPSSdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated18669648; 16381945; 23193290; 18988627; 22135298; 22199227
264VNLQRSLSSPPSSKRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 16381945; 23193290; 18988627; 22135298; 19366988;
265NLQRSLSSPPSSKRPdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 18988627; 22135298; 19366988;
268RSLSSPPSSKRPKTIdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated18669648; 16381945; 23193290; 18988627; 22135298; 22199227
269SLSSPPSSKRPKTISPhosphoSitePlus;curated22135298; 22199227
276SKRPKTISIDENMEPdbPTM 3.0;HPRD 9;curated18452278; 16381945; 23193290; 18988627; 25627689
284IDENMEPSPTGDFYPdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated18669648; 16381945; 23193290; 18452278; 20068231; 18988627;
286ENMEPSPTGDFYPSPdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated18669648; 16381945; 23193290; 18452278; 18988627; 22135298;
Sequence
(Fasta)		MMYSPICLTQ DEFHPFIEAL LPHVRAIAYT WFNLQARKRK YFKKHEKRMS KDEERAVKDE 60
LLSEKPEIKQ KWASRLLAKL RKDIRQEYRE DFVLTVTGKK HPCCVLSNPD QKGKIRRIDC 120
LRQADKVWRL DLVMVILFKG IPLESTDGER LMKSPHCTNP ALCVQPHHIT VSVKELDLFL 180
AYYVQEQDSG QSGSPSHNDP AKNPPGYLED SFVKSGVFNV SELVRVSRTP ITQGTGVNFP 240
IGEIPSQPYY HDMNSGVNLQ RSLSSPPSSK RPKTISIDEN MEPSPTGDFY PSPSSPAAGS 300
RTWHERDQDM SSPTTMKKPE KPLFSSASPQ DSSPRLSTFP QHHHPGIPGV AHSVISTRTP 360
PPPSPLPFPT QAILPPAPSS YFSHPTIRYP PHLNPQDTLK NYVPSYDPSS PQTSQSWYLG 420
421
Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0235--DNA replication
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR000647--CTF/NFI
IPR020604--CTF/NFI_DNA-bd-dom
IPR019739--CTF/NFI_DNA-bd_CS
IPR019548--CTF/NFI_DNA-bd_N
IPR003619--MAD_homology1_Dwarfin-type
PROSITE

PS00349--CTF_NFI_1
PS51080--CTF_NFI_2
Pfam

PF00859--CTF_NFI
PF03165--MH1
PF10524--NfI_DNAbd_pre-N
Gene Ontology

GO:0044300--C:cerebellar mossy fiber
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001106--F:RNA polymerase II transcription corepressor activity
GO:0000981--F:RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0021960--P:anterior commissure morphogenesis
GO:0060689--P:cell differentiation involved in salivary gland development
GO:0002062--P:chondrocyte differentiation
GO:0060486--P:Clara cell differentiation
GO:0071679--P:commissural neuron axon guidance
GO:0006260--P:DNA replication
GO:0010001--P:glial cell differentiation
GO:0030902--P:hindbrain development
GO:0061141--P:lung ciliated cell differentiation
GO:0043392--P:negative regulation of DNA binding
GO:2000795--P:negative regulation of epithelial cell proliferation involved in lung morphogenesis
GO:2000791--P:negative regulation of mesenchymal cell proliferation involved in lung development
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0021740--P:principal sensory nucleus of trigeminal nerve development
GO:0060662--P:salivary gland cavitation
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0060509--P:Type I pneumocyte differentiation
GO:0060510--P:Type II pneumocyte differentiation