| Tag |
Content |
| dbPAF ID |
dbPAF-0000146 |
| Uniprot Accession |
O00631; SARCO_HUMAN; Q6ICV3;
|
| Genbank Protein ID |
NP_003054.1;
|
| Genbank Nucleotide ID |
NM_003063.2;
|
| Protein Name |
Sarcolipin |
| Protein Synonyms/Alias |
|
| Gene Name |
SLN |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Required for muscle-based, non-shivering thermogenesis (By similarity). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle.Functional Description
Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Required for muscle-based, non-shivering thermogenesis (By similarity). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. |
Phosphorylation Sites
|
dbPAF PTMs: 1 |
Sequence
(Fasta) | MGINTRELFL NFTIVLITVI LMWLLVRSYQ Y
32Fasta Sequence
>O00631|SLN|Homo sapiens(Human)
MGINTRELFLNFTIVLITVILMWLLVRSYQY
|
| Keyword |
KW-0002--3D-structure
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-1185--Reference proteome
KW-0703--Sarcoplasmic reticulum
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR008028--Sarcolipin
|
| PROSITE |
|
| Pfam |
PF05366--Sarcolipin
|
| Gene Ontology |
GO:0016021--C:integral component of membrane
GO:0016529--C:sarcoplasmic reticulum
GO:0033017--C:sarcoplasmic reticulum membrane
GO:0051117--F:ATPase binding
GO:0004857--F:enzyme inhibitor activity
GO:0006816--P:calcium ion transport
GO:1901877--P:negative regulation of calcium ion binding
GO:0090281--P:negative regulation of calcium ion import
GO:1901020--P:negative regulation of calcium ion transmembrane transporter activity
GO:0043086--P:negative regulation of catalytic activity
GO:0043242--P:negative regulation of protein complex disassembly
GO:1901881--P:positive regulation of protein depolymerization
GO:0051924--P:regulation of calcium ion transport
GO:1901894--P:regulation of calcium-transporting ATPase activity
GO:1901077--P:regulation of relaxation of muscle
GO:0070296--P:sarcoplasmic reticulum calcium ion transport
|
