dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000145
Uniprot Accession O00629; IMA3_HUMAN; A8K4S6; D3DNM2; O00190;
Genbank Protein ID NP_002259.1;
Genbank Nucleotide ID NM_002268.4;
Protein Name Importin subunit alpha-3
Protein Synonyms/Alias Importin alpha Q1;Qip1;Karyopherin subunit alpha-4;
Gene Name KPNA4
Gene Synonyms/Alias QIP1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
Phosphorylation Sites
dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
24NKGRDLETMRRQRNEPhosphoSitePlus22135298
60HEDICEDSDIDGDYRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18669648; 19690332; 16381945; 23193290; 20068231;
66DSDIDGDYRVQNTSLdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated18669648; 16381945; 23193290; 20562096; 18988627; 22135298;
71GDYRVQNTSLEAIVQdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
72DYRVQNTSLEAIVQNcurated25627689; 20068231
221ITFLRNVTWVMVNLCdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 22817900
474NHENEDIYKLAYEIIPhosphoSitePlus;curated22135298; 25627689; 24961811
Sequence
(Fasta)
MADNEKLDNQ RLKNFKNKGR DLETMRRQRN EVVVELRKNK RDEHLLKRRN VPHEDICEDS 60
DIDGDYRVQN TSLEAIVQNA SSDNQGIQLS AVQAARKLLS SDRNPPIDDL IKSGILPILV 120
HCLERDDNPS LQFEAAWALT NIASGTSEQT QAVVQSNAVP LFLRLLHSPH QNVCEQAVWA 180
LGNIIGDGPQ CRDYVISLGV VKPLLSFISP SIPITFLRNV TWVMVNLCRH KDPPPPMETI 240
QEILPALCVL IHHTDVNILV DTVWALSYLT DAGNEQIQMV IDSGIVPHLV PLLSHQEVKV 300
QTAALRAVGN IVTGTDEQTQ VVLNCDALSH FPALLTHPKE KINKEAVWFL SNITAGNQQQ 360
VQAVIDANLV PMIIHLLDKG DFGTQKEAAW AISNLTISGR KDQVAYLIQQ NVIPPFCNLL 420
TVKDAQVVQV VLDGLSNILK MAEDEAETIG NLIEECGGLE KIEQLQNHEN EDIYKLAYEI 480
IDQFFSSDDI DEDPSLVPEA IQGGTFGFNS SANVPTEGFQ F 522
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR032413--Arm_3
IPR000225--Armadillo
IPR002652--Importin-a_IBB
IPR024931--Importing_su_alpha

PROSITE

PS50176--ARM_REPEAT
PS51214--IBB

Pfam

PF00514--Arm
PF16186--Arm_3
PF01749--IBB

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005643--C:nuclear pore
GO:0005654--C:nucleoplasm
GO:0008139--F:nuclear localization sequence binding
GO:0008565--F:protein transporter activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0019048--P:modulation by virus of host morphology or physiology
GO:0019054--P:modulation by virus of host process
GO:0006607--P:NLS-bearing protein import into nucleus
GO:0042542--P:response to hydrogen peroxide
GO:0019058--P:viral life cycle