| Tag |
Content |
| dbPAF ID |
dbPAF-0000144 |
| Uniprot Accession |
O00626; CCL22_HUMAN; A0N0Q6; B2R4W2;
|
| Genbank Protein ID |
NP_002981.2;
|
| Genbank Nucleotide ID |
NM_002990.4;
|
| Protein Name |
C-C motif chemokine 22 |
| Protein Synonyms/Alias |
CC chemokine STCP-1;MDC(1-69);Macrophage-derived chemokine;Small-inducible cytokine A22;Stimulated T-cell chemotactic protein 1; |
| Gene Name |
CCL22 |
| Gene Synonyms/Alias |
MDC;SCYA22;A-152E5.1; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.Functional Description
May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 54 | LRVVKHFYWTSDSCP | PhosphoSitePlus | 22135298 |
|
Sequence
(Fasta) | MDRLQTALLV VLVLLAVALQ ATEAGPYGAN MEDSVCCRDY VRYRLPLRVV KHFYWTSDSC 60
PRPGVVLLTF RDKEICADPR VPWVKMILNK LSQ
94Fasta Sequence
>O00626|CCL22|Homo sapiens(Human)
MDRLQTALLVVLVLLAVALQATEAGPYGANMEDSVCCRDYVRYRLPLRVVKHFYWTSDSCPRPGVVLLTFRDKEICADPRVPWVKMILNKLSQ
|
| Keyword |
KW-0145--Chemotaxis
KW-0181--Complete proteome
KW-0202--Cytokine
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
|
| Interpro |
IPR030598--CCL22
IPR000827--Chemokine_CC_CS
IPR001811--Chemokine_IL8-like_dom
|
| PROSITE |
PS00472--SMALL_CYTOKINES_CC
|
| Pfam |
PF00048--IL8
|
| Gene Ontology |
GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:0048020--F:CCR chemokine receptor binding
GO:0008009--F:chemokine activity
GO:0007267--P:cell-cell signaling
GO:0071346--P:cellular response to interferon-gamma
GO:0071347--P:cellular response to interleukin-1
GO:0071356--P:cellular response to tumor necrosis factor
GO:0070098--P:chemokine-mediated signaling pathway
GO:0006935--P:chemotaxis
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006955--P:immune response
GO:0006954--P:inflammatory response
GO:0048247--P:lymphocyte chemotaxis
GO:0002548--P:monocyte chemotaxis
GO:0030593--P:neutrophil chemotaxis
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0043547--P:positive regulation of GTPase activity
GO:0009615--P:response to virus
GO:0007165--P:signal transduction
|
