dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000142
Uniprot Accession O00623; PEX12_HUMAN; B2R6M2;
Genbank Protein ID NP_000277.1;
Genbank Nucleotide ID NM_000286.2;
Protein Name Peroxisome assembly protein 12
Protein Synonyms/Alias Peroxin-12;Peroxisome assembly factor 3;PAF-3;
Gene Name PEX12
Gene Synonyms/Alias PAF3;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Required for protein import into peroxisomes.
Phosphorylation Sites
 dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
275ENQETIKSLTALPTPPhosphoSitePlus22135298
277QETIKSLTALPTPPPPhosphoSitePlus22135298
281KSLTALPTPPPPVHLPhosphoSitePlus22135298
294HLDYNSDSPLLPKMKcurated25627689
Sequence
(Fasta)		MAEHGAHFTA ASVADDQPSI FEVVAQDSLM TAVRPALQHV VKVLAESNPT HYGFLWRWFD 60
EIFTLLDLLL QQHYLSRTSA SFSENFYGLK RIVMGDTHKS QRLASAGLPK QQLWKSIMFL 120
VLLPYLKVKL EKLVSSLREE DEYSIHPPSS RWKRFYRAFL AAYPFVNMAW EGWFLVQQLR 180
YILGKAQHHS PLLRLAGVQL GRLTVQDIQA LEHKPAKASM MQQPARSVSE KINSALKKAV 240
GGVALSLSTG LSVGVFFLQF LDWWYSSENQ ETIKSLTALP TPPPPVHLDY NSDSPLLPKM 300
KTVCPLCRKT RVNDTVLATS GYVFCYRCVF HYVRSHQACP ITGYPTEVQH LIKLYSPEN 360
Keyword

KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0472--Membrane
KW-0479--Metal-binding
KW-0576--Peroxisome
KW-0958--Peroxisome biogenesis disorder
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0861--Zellweger syndrome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR017375--PEX12
IPR006845--Pex_N
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE
Pfam

PF04757--Pex2_Pex12
Gene Ontology

GO:0005779--C:integral component of peroxisomal membrane
GO:1990429--C:peroxisomal importomer complex
GO:0005778--C:peroxisomal membrane
GO:0005777--C:peroxisome
GO:0008022--F:protein C-terminus binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007031--P:peroxisome organization
GO:0016558--P:protein import into peroxisome matrix
GO:0006513--P:protein monoubiquitination
GO:0006625--P:protein targeting to peroxisome