dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000141
Uniprot Accession O00622; CYR61_HUMAN; O14934; O43775; Q9BZL7;
Genbank Protein ID NP_001545.2;
Genbank Nucleotide ID NM_001554.4;
Protein Name Protein CYR61
Protein Synonyms/Alias CCN family member 1;Cysteine-rich angiogenic inducer 61;Insulin-like growth factor-binding protein 10;IBP-10;IGF-binding protein 10;IGFBP-10;Protein GIG1;
Gene Name CYR61
Gene Synonyms/Alias CCN1;GIG1;IGFBP10;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
14RALALVVTLLHLTRLPhosphoSitePlus22135298
84ECNFGASSTALKGICPhosphoSitePlus22135298
85CNFGASSTALKGICRPhosphoSitePlus22135298
221GMEPRILYNPLQGQKPhosphoSitePlus22135298
277RPCGQPVYSSLKKGKPhosphoSitePlus22135298
278PCGQPVYSSLKKGKKPhosphoSitePlus22135298
370NEAAFPFYRLFNDIHcurated25348954
Sequence
(Fasta)		MSSRIARALA LVVTLLHLTR LALSTCPAAC HCPLEAPKCA PGVGLVRDGC GCCKVCAKQL 60
NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC EYNSRIYQNG ESFQPNCKHQ 120
CTCIDGAVGC IPLCPQELSL PNLGCPNPRL VKVTGQCCEE WVCDEDSIKD PMEDQDGLLG 180
KELGFDASEV ELTRNNELIA VGKGSSLKRL PVFGMEPRIL YNPLQGQKCI VQTTSWSQCS 240
KTCGTGISTR VTNDNPECRL VKETRICEVR PCGQPVYSSL KKGKKCSKTK KSPEPVRFTY 300
AGCLSVKKYR PKYCGSCVDG RCCTPQLTRT VKMRFRCEDG ETFSKNVMMI QSCKCNYNCP 360
HANEAAFPFY RLFNDIHKFR D 382
Keyword

KW-0002--3D-structure
KW-0130--Cell adhesion
KW-0145--Chemotaxis
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0340--Growth factor binding
KW-0358--Heparin-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
Interpro

IPR006207--Cys_knot_C
IPR006208--Glyco_hormone_CN
IPR009030--Growth_fac_rcpt_N_dom
IPR000867--IGFBP-like
IPR012395--IGFBP_CNN
IPR017891--Insulin_GF-bd_Cys-rich_CS
IPR000884--TSP1_rpt
IPR001007--VWF_dom
PROSITE

PS01185--CTCK_1
PS01225--CTCK_2
PS00222--IGFBP_N_1
PS51323--IGFBP_N_2
PS50092--TSP1
PS01208--VWFC_1
PS50184--VWFC_2
Pfam

PF00007--Cys_knot
PF00219--IGFBP
PF00093--VWC
Gene Ontology

GO:0031012--C:extracellular matrix
GO:0005578--C:proteinaceous extracellular matrix
GO:0050840--F:extracellular matrix binding
GO:0008201--F:heparin binding
GO:0005178--F:integrin binding
GO:0009653--P:anatomical structure morphogenesis
GO:0003278--P:apoptotic process involved in heart morphogenesis
GO:0060413--P:atrial septum morphogenesis
GO:0003181--P:atrioventricular valve morphogenesis
GO:0007155--P:cell adhesion
GO:0008283--P:cell proliferation
GO:0007267--P:cell-cell signaling
GO:0006935--P:chemotaxis
GO:0060591--P:chondroblast differentiation
GO:0060710--P:chorio-allantoic fusion
GO:0030198--P:extracellular matrix organization
GO:0002041--P:intussusceptive angiogenesis
GO:0060716--P:labyrinthine layer blood vessel development
GO:0043066--P:negative regulation of apoptotic process
GO:0060548--P:negative regulation of cell death
GO:0001649--P:osteoblast differentiation
GO:0030513--P:positive regulation of BMP signaling pathway
GO:0061036--P:positive regulation of cartilage development
GO:0030335--P:positive regulation of cell migration
GO:0010811--P:positive regulation of cell-substrate adhesion
GO:2000304--P:positive regulation of ceramide biosynthetic process
GO:0043280--P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045669--P:positive regulation of osteoblast differentiation
GO:0033690--P:positive regulation of osteoblast proliferation
GO:0010518--P:positive regulation of phospholipase activity
GO:0045860--P:positive regulation of protein kinase activity
GO:0001934--P:positive regulation of protein phosphorylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0072593--P:reactive oxygen species metabolic process
GO:0001558--P:regulation of cell growth
GO:0070372--P:regulation of ERK1 and ERK2 cascade
GO:0007165--P:signal transduction
GO:0003281--P:ventricular septum development
GO:0044319--P:wound healing, spreading of cells