Tag |
Content |
dbPAF ID |
dbPAF-0000140 |
Uniprot Accession |
O00592; PODXL_HUMAN; A6NHX8; Q52LZ7; Q53ER6; |
Genbank Protein ID |
NP_001018121.1; NP_005388.2; |
Genbank Nucleotide ID |
NM_001018111.2; NM_005397.3; |
Protein Name |
Podocalyxin |
Protein Synonyms/Alias |
GCTM-2 antigen;Gp200;Podocalyxin-like protein 1;PC;PCLP-1; |
Gene Name |
PODXL |
Gene Synonyms/Alias |
PCLP;PCLP1; |
Organism |
Homo sapiens(Human) |
NCBI Taxa ID |
9606 |
Functional Description (View all) |
Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.Functional Description
Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
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Phosphorylation Sites
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dbPAF PTMs: 39 (View all) |
Sequence (Fasta) | MRCALALSAL LLLLSTPPLL PSSPSPSPSP SQNATQTTTD SSNKTAPTPA SSVTIMATDT 60 AQQSTVPTSK ANEILASVKA TTLGVSSDSP GTTTLAQQVS GPVNTTVARG GGSGNPTTTI 120 ESPKSTKSAD TTTVATSTAT AKPNTTSSQN GAEDTTNSGG KSSHSVTTDL TSTKAEHLTT 180 PHPTSPLSPR QPTSTHPVAT PTSSGHDHLM KISSSSSTVA IPGYTFTSPG MTTTLLETVF 240 HHVSQAGLEL LTSGDLPTLA SQSAGITASS VISQRTQQTS SQMPASSTAP SSQETVQPTS 300 PATALRTPTL PETMSSSPTA ASTTHRYPKT PSPTVAHESN WAKCEDLETQ TQSEKQLVLN 360 LTGNTLCAGG ASDEKLISLI CRAVKATFNP AQDKCGIRLA SVPGSQTVVV KEITIHTKLP 420 AKDVYERLKD KWDELKEAGV SDMKLGDQGP PEEAEDRFSM PLIITIVCMA SFLLLVAALY 480 GCCHQRLSQR KDQQRLTEEL QTVENGYHDN PTLEVMETSS EMQEKKVVSL NGELGDSWIV 540 PLDNLTKDDL DEEEDTHL
559Fasta Sequence
>O00592|PODXL|Homo sapiens(Human) MRCALALSALLLLLSTPPLLPSSPSPSPSPSQNATQTTTDSSNKTAPTPASSVTIMATDTAQQSTVPTSKANEILASVKATTLGVSSDSPGTTTLAQQVSGPVNTTVARGGGSGNPTTTIESPKSTKSADTTTVATSTATAKPNTTSSQNGAEDTTNSGGKSSHSVTTDLTSTKAEHLTTPHPTSPLSPRQPTSTHPVATPTSSGHDHLMKISSSSSTVAIPGYTFTSPGMTTTLLETVFHHVSQAGLELLTSGDLPTLASQSAGITASSVISQRTQQTSSQMPASSTAPSSQETVQPTSPATALRTPTLPETMSSSPTAASTTHRYPKTPSPTVAHESNWAKCEDLETQTQSEKQLVLNLTGNTLCAGGASDEKLISLICRAVKATFNPAQDKCGIRLASVPGSQTVVVKEITIHTKLPAKDVYERLKDKWDELKEAGVSDMKLGDQGPPEEAEDRFSMPLIITIVCMASFLLLVAALYGCCHQRLSQRKDQQRLTEELQTVENGYHDNPTLEVMETSSEMQEKKVVSLNGELGDSWIVPLDNLTKDDLDEEEDTHL
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Keyword |
KW-0025--Alternative splicing KW-0130--Cell adhesion KW-1003--Cell membrane KW-0966--Cell projection KW-0181--Complete proteome KW-0903--Direct protein sequencing KW-0325--Glycoprotein KW-0472--Membrane KW-0597--Phosphoprotein KW-0621--Polymorphism KW-1185--Reference proteome KW-0732--Signal KW-0812--Transmembrane KW-1133--Transmembrane helix
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Interpro |
IPR013836--CD34/Podocalyxin IPR017403--PODXL
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PROSITE |
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Pfam |
PF06365--CD34_antigen
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Gene Ontology |
GO:0016324--C:apical plasma membrane GO:0044297--C:cell body GO:0005737--C:cytoplasm GO:0070062--C:extracellular exosome GO:0005615--C:extracellular space GO:0030175--C:filopodium GO:0005887--C:integral component of plasma membrane GO:0043231--C:intracellular membrane-bounded organelle GO:0030027--C:lamellipodium GO:0045121--C:membrane raft GO:0031528--C:microvillus membrane GO:0005886--C:plasma membrane GO:0001726--C:ruffle GO:0036057--C:slit diaphragm GO:0007155--P:cell adhesion GO:0016477--P:cell migration GO:0072175--P:epithelial tube formation GO:0072015--P:glomerular visceral epithelial cell development GO:0050900--P:leukocyte migration GO:0007162--P:negative regulation of cell adhesion GO:0022408--P:negative regulation of cell-cell adhesion GO:0030335--P:positive regulation of cell migration GO:0033634--P:positive regulation of cell-cell adhesion mediated by integrin GO:0032534--P:regulation of microvillus assembly
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