| Tag |
Content |
| dbPAF ID |
dbPAF-0000139 |
| Uniprot Accession |
O00591; GBRP_HUMAN; A8KA36; D3DQL2; Q32MJ1;
|
| Genbank Protein ID |
NP_001278914.1; NP_055026.1; XP_011532804.1; XP_011532805.1; XP_011532806.1; XP_011532807.1;
|
| Genbank Nucleotide ID |
NM_001291985.1; NM_014211.2; XM_011534502.1; XM_011534503.1; XM_011534504.1; XM_011534505.1;
|
| Protein Name |
Gamma-aminobutyric acid receptor subunit pi |
| Protein Synonyms/Alias |
GABA(A) receptor subunit pi; |
| Gene Name |
GABRP |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.Functional Description
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MNYSLHLAFV CLSLFTERMC IQGSQFNVEV GRSDKLSLPG FENLTAGYNK FLRPNFGGEP 60
VQIALTLDIA SISSISESNM DYTATIYLRQ RWMDQRLVFE GNKSFTLDAR LVEFLWVPDT 120
YIVESKKSFL HEVTVGNRLI RLFSNGTVLY ALRITTTVAC NMDLSKYPMD TQTCKLQLES 180
WGYDGNDVEF TWLRGNDSVR GLEHLRLAQY TIERYFTLVT RSQQETGNYT RLVLQFELRR 240
NVLYFILETY VPSTFLVVLS WVSFWISLDS VPARTCIGVT TVLSMTTLMI GSRTSLPNTN 300
CFIKAIDVYL GICFSFVFGA LLEYAVAHYS SLQQMAAKDR GTTKEVEEVS ITNIINSSIS 360
SFKRKISFAS IEISSDNVDY SDLTMKTSDK FKFVFREKMG RIVDYFTIQN PSNVDHYSKL 420
LFPLIFMLAN VFYWAYYMYF
441Fasta Sequence
>O00591|GABRP|Homo sapiens(Human)
MNYSLHLAFVCLSLFTERMCIQGSQFNVEVGRSDKLSLPGFENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGNKSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEEVSITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYYMYF
|
| Keyword |
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0868--Chloride
KW-0869--Chloride channel
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0407--Ion channel
KW-0406--Ion transport
KW-0472--Membrane
KW-0621--Polymorphism
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0732--Signal
KW-0770--Synapse
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
|
| Interpro |
IPR006028--GABAA/Glycine_rcpt
IPR008100--GABAAp_rcpt
IPR006202--Neur_chan_lig-bd
IPR006201--Neur_channel
IPR006029--Neurotrans-gated_channel_TM
IPR018000--Neurotransmitter_ion_chnl_CS
|
| PROSITE |
PS00236--NEUROTR_ION_CHANNEL
|
| Pfam |
PF02931--Neur_chan_LBD
PF02932--Neur_chan_memb
|
| Gene Ontology |
GO:0030054--C:cell junction
GO:0034707--C:chloride channel complex
GO:1902711--C:GABA-A receptor complex
GO:0005887--C:integral component of plasma membrane
GO:0043005--C:neuron projection
GO:0045211--C:postsynaptic membrane
GO:0045202--C:synapse
GO:0005254--F:chloride channel activity
GO:0005230--F:extracellular ligand-gated ion channel activity
GO:0004890--F:GABA-A receptor activity
GO:1902476--P:chloride transmembrane transport
GO:0050877--P:neurological system process
GO:0042391--P:regulation of membrane potential
GO:0007165--P:signal transduction
GO:0007268--P:synaptic transmission
|
