dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000138
Uniprot Accession O00590; ACKR2_HUMAN; B2R8Y8; O00537; Q53YA1; Q86UN9; Q96A02;
Genbank Protein ID NP_001287.2;
Genbank Nucleotide ID NM_001296.4;
Protein Name Atypical chemokine receptor 2
Protein Synonyms/Alias C-C chemokine receptor D6;Chemokine receptor CCR-10;Chemokine receptor CCR-9;Chemokine-binding protein 2;Chemokine-binding protein D6;
Gene Name ACKR2
Gene Synonyms/Alias CCBP2;CCR10;CMKBR9;D6;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.
Phosphorylation Sites
dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
139IFFISCMSLDKYLEIPhosphoSitePlus22135298
161RLRTRAKSLLLATIVdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20058876; 16381945; 23193290; 18988627; 22135298; 22817900
Sequence
(Fasta)
MAATASPQPL ATEDADSENS SFYYYDYLDE VAFMLCRKDA VVSFGKVFLP VFYSLIFVLG 60
LSGNLLLLMV LLRYVPRRRM VEIYLLNLAI SNLLFLVTLP FWGISVAWHW VFGSFLCKMV 120
STLYTINFYS GIFFISCMSL DKYLEIVHAQ PYHRLRTRAK SLLLATIVWA VSLAVSIPDM 180
VFVQTHENPK GVWNCHADFG GHGTIWKLFL RFQQNLLGFL LPLLAMIFFY SRIGCVLVRL 240
RPAGQGRALK IAAALVVAFF VLWFPYNLTL FLHTLLDLQV FGNCEVSQHL DYALQVTESI 300
AFLHCCFSPI LYAFSSHRFR QYLKAFLAAV LGWHLAPGTA QASLSSCSES SILTAQEEMT 360
GMNDLGERQS ENYPNKEDVG NKSA 385
Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0967--Endosome
KW-0297--G-protein coupled receptor
KW-0325--Glycoprotein
KW-0395--Inflammatory response
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0807--Transducer
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001277--Chemokine_CXCR4
IPR000355--Chemokine_rcpt
IPR000276--GPCR_Rhodpsn
IPR017452--GPCR_Rhodpsn_7TM

PROSITE

PS50262--G_PROTEIN_RECEP_F1_2

Pfam

PF00001--7tm_1

Gene Ontology

GO:0005884--C:actin filament
GO:0005769--C:early endosome
GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0055037--C:recycling endosome
GO:0016493--F:C-C chemokine receptor activity
GO:0016494--F:C-X-C chemokine receptor activity
GO:0004950--F:chemokine receptor activity
GO:0005044--F:scavenger receptor activity
GO:0070098--P:chemokine-mediated signaling pathway
GO:0006935--P:chemotaxis
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006955--P:immune response
GO:0006954--P:inflammatory response
GO:0007275--P:multicellular organismal development
GO:0042119--P:neutrophil activation
GO:0006898--P:receptor-mediated endocytosis