| Tag |
Content |
| dbPAF ID |
dbPAF-0000137 |
| Uniprot Accession |
O00587; MFNG_HUMAN; B4DLT6; O43730; Q504S9;
|
| Genbank Protein ID |
NP_001159815.1; NP_002396.2;
|
| Genbank Nucleotide ID |
NM_001166343.1; NM_002405.3;
|
| Protein Name |
Beta-1,3-N-acetylglucosaminyltransferase manic fringe |
| Protein Synonyms/Alias |
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; |
| Gene Name |
MFNG |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling. Possesses fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity.Functional Description
Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling. Possesses fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 63 | VFIAVKTTRAFHRLR | PhosphoSitePlus | 22135298 |
|
Sequence
(Fasta) | MQCRLPRGLA GALLTLLCMG LLCLRYHLNL SPQRVQGTPE LSQPNPGPPK LQLHDVFIAV 60
KTTRAFHRLR LELLLDTWVS RTREQTFVFT DSPDKGLQER LGSHLVVTNC SAEHSHPALS 120
CKMAAEFDTF LASGLRWFCH VDDDNYVNPR ALLQLLRAFP LARDVYVGRP SLNRPIHASE 180
PQPHNRTRLV QFWFATGGAG FCINRKLALK MAPWASGSRF MDTSALIRLP DDCTMGYIIE 240
CKLGGRLQPS PLFHSHLETL QLLRTAQLPE QVTLSYGVFE GKLNVIKLQG PFSPEEDPSR 300
FRSLHCLLYP DTPWCPQLGA R
322Fasta Sequence
>O00587|MFNG|Homo sapiens(Human)
MQCRLPRGLAGALLTLLCMGLLCLRYHLNLSPQRVQGTPELSQPNPGPPKLQLHDVFIAVKTTRAFHRLRLELLLDTWVSRTREQTFVFTDSPDKGLQERLGSHLVVTNCSAEHSHPALSCKMAAEFDTFLASGLRWFCHVDDDNYVNPRALLQLLRAFPLARDVYVGRPSLNRPIHASEPQPHNRTRLVQFWFATGGAGFCINRKLALKMAPWASGSRFMDTSALIRLPDDCTMGYIIECKLGGRLQPSPLFHSHLETLQLLRTAQLPEQVTLSYGVFEGKLNVIKLQGPFSPEEDPSRFRSLHCLLYPDTPWCPQLGAR
|
| Keyword |
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0328--Glycosyltransferase
KW-0333--Golgi apparatus
KW-0464--Manganese
KW-0472--Membrane
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0735--Signal-anchor
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR017374--Fringe
IPR003378--Fringe-like
|
| PROSITE |
|
| Pfam |
PF02434--Fringe
|
| Gene Ontology |
GO:0005615--C:extracellular space
GO:0030173--C:integral component of Golgi membrane
GO:0046872--F:metal ion binding
GO:0033829--F:O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
GO:0002315--P:marginal zone B cell differentiation
GO:0007389--P:pattern specification process
GO:0045747--P:positive regulation of Notch signaling pathway
GO:0032092--P:positive regulation of protein binding
|
