| Tag |
Content |
| dbPAF ID |
dbPAF-0000136 |
| Uniprot Accession |
O00584; RNT2_HUMAN; B2RDA7; E1P5C3; Q5T8Q0; Q8TCU2; Q9BZ46; Q9BZ47;
|
| Genbank Protein ID |
NP_003721.2;
|
| Genbank Nucleotide ID |
NM_003730.4;
|
| Protein Name |
Ribonuclease T2 |
| Protein Synonyms/Alias |
Ribonuclease 6; |
| Gene Name |
RNASET2 |
| Gene Synonyms/Alias |
RNASE6PL; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism.Functional Description
Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MRPAALRGAL LGCLCLALLC LGGADKRLRD NHEWKKLIMV QHWPETVCEK IQNDCRDPPD 60
YWTIHGLWPD KSEGCNRSWP FNLEEIKDLL PEMRAYWPDV IHSFPNRSRF WKHEWEKHGT 120
CAAQVDALNS QKKYFGRSLE LYRELDLNSV LLKLGIKPSI NYYQVADFKD ALARVYGVIP 180
KIQCLPPSQD EEVQTIGQIE LCLTKQDQQL QNCTEPGEQP SPKQEVWLAN GAAESRGLRV 240
CEDGPVFYPP PKKTKH
257Fasta Sequence
>O00584|RNASET2|Homo sapiens(Human)
MRPAALRGALLGCLCLALLCLGGADKRLRDNHEWKKLIMVQHWPETVCEKIQNDCRDPPDYWTIHGLWPDKSEGCNRSWPFNLEEIKDLLPEMRAYWPDVIHSFPNRSRFWKHEWEKHGTCAAQVDALNSQKKYFGRSLELYRELDLNSVLLKLGIKPSINYYQVADFKDALARVYGVIPKIQCLPPSQDEEVQTIGQIELCLTKQDQQLQNCTEPGEQPSPKQEVWLANGAAESRGLRVCEDGPVFYPPPKKTKH
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0255--Endonuclease
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0458--Lysosome
KW-0540--Nuclease
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
|
| Interpro |
IPR001568--RNase_T2-like
IPR018188--RNase_T2_AS
|
| PROSITE |
PS00530--RNASE_T2_1
PS00531--RNASE_T2_2
|
| Pfam |
PF00445--Ribonuclease_T2
|
| Gene Ontology |
GO:0005788--C:endoplasmic reticulum lumen
GO:0070062--C:extracellular exosome
GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:0043202--C:lysosomal lumen
GO:0005764--C:lysosome
GO:0004521--F:endoribonuclease activity
GO:0004540--F:ribonuclease activity
GO:0033897--F:ribonuclease T2 activity
GO:0003723--F:RNA binding
GO:0006401--P:RNA catabolic process
GO:0090501--P:RNA phosphodiester bond hydrolysis
GO:0090502--P:RNA phosphodiester bond hydrolysis, endonucleolytic
|
