dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000132
Uniprot Accession O00567; NOP56_HUMAN; Q2M3T6; Q9NQ05;
Genbank Protein ID NP_006383.2;
Genbank Nucleotide ID NM_006392.3;
Protein Name Nucleolar protein 56
Protein Synonyms/Alias Nucleolar protein 5A;
Gene Name NOP56
Gene Synonyms/Alias NOL5A;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs.
Phosphorylation Sites
 dbPAF PTMs: 45 (View all)
PositionPeptidesSourceReferences ( PMIDs )
82DLRLLLETHLPSKKKdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 22817900
86LLETHLPSKKKKVLLdbPTM 3.0;PHOSIDA;PhosphoSitePlus;curated21406692; 16381945; 23193290; 21081558; 22135298; 22817900
151AQLGLGHSYSRAKVKcurated20873877
152QLGLGHSYSRAKVKFcurated20873877
153LGLGHSYSRAKVKFNcurated20873877; 22817900
210IINDNATYCRLAQFIPhosphoSitePlus22135298
268LINIESFSSRVVSLSPhosphoSitePlus22135298
295KMSQVAPSLSALIGEdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
297SQVAPSLSALIGEAVdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627; 22817900
314RLIAHAGSLTNLAKYdbPTM 3.0;PhosphoSitePlus;UniProt;curated20815410; 21406692; 16381945; 23193290; 22135298; 23911959;
316IAHAGSLTNLAKYPAcurated25003641; 22817900
321SLTNLAKYPASTVQIPHOSIDA21081558
325LAKYPASTVQILGAEPHOSIDA21081558
369AKNKGRISRYLANKCdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 22817900
406EQVEERLSFYETGEIdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated16565220; 16381945; 23193290; 18988627; 19060867; 22135298;
461LAALALASSENSSSTPhosphoSitePlus;curated22135298; 23898821; 25849741
462AALALASSENSSSTPcurated23898821; 25849741
465ALASSENSSSTPEECPhosphoSitePlus;curated22135298; 23898821; 25849741
466LASSENSSSTPEECEdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19413330; 16381945; 23193290; 18988627; 22135298; 23898821;
467ASSENSSSTPEECEEdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated19413330; 16381945; 23193290; 18988627; 19060867; 22135298;
Sequence
(Fasta)		MVLLHVLFEH AVGYALLALK EVEEISLLQP QVEESVLNLG KFHSIVRLVA FCPFASSQVA 60
LENANAVSEG VVHEDLRLLL ETHLPSKKKK VLLGVGDPKI GAAIQEELGY NCQTGGVIAE 120
ILRGVRLHFH NLVKGLTDLS ACKAQLGLGH SYSRAKVKFN VNRVDNMIIQ SISLLDQLDK 180
DINTFSMRVR EWYGYHFPEL VKIINDNATY CRLAQFIGNR RELNEDKLEK LEELTMDGAK 240
AKAILDASRS SMGMDISAID LINIESFSSR VVSLSEYRQS LHTYLRSKMS QVAPSLSALI 300
GEAVGARLIA HAGSLTNLAK YPASTVQILG AEKALFRALK TRGNTPKYGL IFHSTFIGRA 360
AAKNKGRISR YLANKCSIAS RIDCFSEVPT SVFGEKLREQ VEERLSFYET GEIPRKNLDV 420
MKEAMVQAEE AAAEITRKLE KQEKKRLKKE KKRLAALALA SSENSSSTPE ECEEMSEKPK 480
KKKKQKPQEV PQENGMEDPS ISFSKPKKKK SFSKEELMSS DLEETAGSTS IPKRKKSTPK 540
EETVNDPEEA GHRSGSKKKR KFSKEEPVSS GPEEAVGKSS SKKKKKFHKA SQED 595
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0523--Neurodegeneration
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0687--Ribonucleoprotein
KW-0690--Ribosome biogenesis
KW-0950--Spinocerebellar ataxia
Interpro

IPR012974--NOP5_N
IPR002687--Nop_dom
IPR012976--NOSIC
PROSITE

PS51358--NOP
Pfam

PF01798--Nop
PF08156--NOP5NT
Gene Ontology

GO:0031428--C:box C/D snoRNP complex
GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0070761--C:pre-snoRNP complex
GO:0005732--C:small nucleolar ribonucleoprotein complex
GO:0032040--C:small-subunit processome
GO:1990226--F:histone methyltransferase binding
GO:0044822--F:poly(A) RNA binding
GO:0003723--F:RNA binding
GO:0030515--F:snoRNA binding
GO:0000154--P:rRNA modification
GO:0006364--P:rRNA processing