dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000131
Uniprot Accession O00566; MPP10_HUMAN; A0AVJ8;
Genbank Protein ID NP_005782.1;
Genbank Nucleotide ID NM_005791.2;
Protein Name U3 small nucleolar ribonucleoprotein protein MPP10
Protein Synonyms/Alias M phase phosphoprotein 10;
Gene Name MPHOSPH10
Gene Synonyms/Alias MPP10;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
Phosphorylation Sites
 dbPAF PTMs: 29 (View all)
PositionPeptidesSourceReferences ( PMIDs )
10PQVWRRRTLERCLTEcurated23882029
22LTEVGKATGRPECFLdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
37TIQEGLASKFTSLTKdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627; 22817900
41GLASKFTSLTKVLYDcurated20068231
61ENGRIHGSPLQKLVIdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated19691289; 20068231; 16381945; 23193290; 18988627; 19060867;
120QEREEDGSEIEADDKdbPTM 3.0;HPRD 9;PhosphoSitePlus;UniProt;curated19007248; 16381945; 23193290; 19691289; 20068231; 21406692;
139DLEEEEVSDMGNDDPdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated19007248; 16381945; 23193290; 20068231; 20363803; 21406692;
158RAENSSKSDLRKSPVdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated18669648; 16381945; 23193290; 18988627; 19060867; 22135298;
163SKSDLRKSPVFSDEDdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18669648; 16381945; 23193290; 19276368; 20068231;
167LRKSPVFSDEDSDLDdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18669648; 19690332; 16381945; 23193290; 20068231;
171PVFSDEDSDLDFDISdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18669648; 19690332; 16381945; 23193290; 19276368;
178SDLDFDISKLEQQSKdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;curated18669648; 16381945; 23193290; 18988627; 25850435; 20873877;
208DDKFFKLSEMEAYLEdbPTM 3.0;HPRD 919651622; 16381945; 23193290; 18988627
242DFFEDIDSDEDEGGLdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18669648; 19690332; 16381945; 23193290; 20068231;
252DEGGLFGSKKLKSGKcurated22817900; 26074081
275DFFDPVESDEDITNVdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 16381945; 23193290; 20068231; 20164059; 20363803;
280VESDEDITNVHDDELdbPTM 3.0;HPRD 9;SysPTM 2.017081983; 16381945; 23193290; 18988627; 19366988
289VHDDELDSNKEDDEIdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 16381945; 23193290; 20068231; 20164059; 20363803;
309EELSISETDEDDDLQPhosphoSitePlus22135298
332KESLKRVTFALPDDAPhosphoSitePlus22135298
Sequence
(Fasta)		MAPQVWRRRT LERCLTEVGK ATGRPECFLT IQEGLASKFT SLTKVLYDFN KILENGRIHG 60
SPLQKLVIEN FDDEQIWQQL ELQNEPILQY FQNAVSETIN DEDISLLPES EEQEREEDGS 120
EIEADDKEDL EDLEEEEVSD MGNDDPEMGE RAENSSKSDL RKSPVFSDED SDLDFDISKL 180
EQQSKVQNKG QGKPREKSIV DDKFFKLSEM EAYLENIEKE EERKDDNDEE EEDIDFFEDI 240
DSDEDEGGLF GSKKLKSGKS SRNLKYKDFF DPVESDEDIT NVHDDELDSN KEDDEIAEEE 300
AEELSISETD EDDDLQENED NKQHKESLKR VTFALPDDAE TEDTGVLNVK KNSDEVKSSF 360
EKRQEKMNEK IASLEKELLE KKPWQLQGEV TAQKRPENSL LEETLHFDHA VRMAPVITEE 420
TTLQLEDIIK QRIRDQAWDD VVRKEKPKED AYEYKKRLTL DHEKSKLSLA EIYEQEYIKL 480
NQQKTAEEEN PEHVEIQKMM DSLFLKLDAL SNFHFIPKPP VPEIKVVSNL PAITMEEVAP 540
VSVSDAALLA PEEIKEKNKA GDIKTAAEKT ATDKKRERRK KKYQKRMKIK EKEKRRKLLE 600
KSSVDQAGKY SKTVASEKLK QLTKTGKASF IKDEGKDKAL KSSQAFFSKL QDQVKMQIND 660
AKKTEKKKKK RQDISVHKLK L 682
Keyword

KW-0007--Acetylation
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0687--Ribonucleoprotein
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0832--Ubl conjugation
Interpro

IPR012173--snoRNP_Mpp10
PROSITE
Pfam

PF04006--Mpp10
Gene Ontology

GO:0005694--C:chromosome
GO:0034457--C:Mpp10 complex
GO:0005730--C:nucleolus
GO:0005732--C:small nucleolar ribonucleoprotein complex
GO:0032040--C:small-subunit processome
GO:0044822--F:poly(A) RNA binding
GO:0010923--P:negative regulation of phosphatase activity
GO:0006396--P:RNA processing
GO:0008380--P:RNA splicing
GO:0000375--P:RNA splicing, via transesterification reactions
GO:0006364--P:rRNA processing