dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000130
Uniprot Accession O00562; PITM1_HUMAN; A6NME4; Q6T7X3; Q8TBN3; Q9BZ73;
Genbank Protein ID NP_001124320.1; NP_004901.2;
Genbank Nucleotide ID NM_001130848.1; NM_004910.2;
Protein Name Membrane-associated phosphatidylinositol transfer protein 1
Protein Synonyms/Alias Drosophila retinal degeneration B homolog;Phosphatidylinositol transfer protein, membrane-associated 1;PITPnm 1;Pyk2 N-terminal domain-interacting receptor 2;NIR-2;
Gene Name PITPNM1
Gene Synonyms/Alias DRES9;NIR2;PITPNM;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions.
Phosphorylation Sites
 dbPAF PTMs: 27 (View all)
PositionPeptidesSourceReferences ( PMIDs )
59PGGSGQYTHKVYHVGdbPTM 3.0;PhosphoSitePlus;UniProt;curated12225667; 16381945; 23193290; 22135298; 22817900
285ARSAASNTGTPDGPEcurated25627689
287SAASNTGTPDGPEAPdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated15125835; 16381945; 23193290; 22135298; 22199227; 22817900
300APPGPDASPDASFGKPhosphoSitePlus;curated22135298; 25627689; 22199227
304PDASPDASFGKQWSScurated22199227
315QWSSSSRSSYSSQHGcurated23898821; 23663014
316WSSSSRSSYSSQHGGcurated23663014
326SQHGGAVSPQSLSEWcurated23898821
373KEMTKWNSNDFIDAFPhosphoSitePlus;curated22135298; 23090842; 23663014
382DFIDAFASPVEAEGTdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated15125835; 16381945; 23193290; 22135298; 22817900
389SPVEAEGTPEPGAEAdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated15125835; 16381945; 23193290; 22135298; 22817900
509DGDSLSRSQDHIPLAPhosphoSitePlus;curated22135298; 20873877
528LATSSSRYQGAVATVPhosphoSitePlus22135298
593RGSSRRGSMNNELLSdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated17081983; 16381945; 23193290; 22115753; 18452278; 18988627;
600SMNNELLSPEFGPVRdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 16381945; 23193290; 19276368; 18988627; 21081558;
621VEGLGRGSPEPSALPdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;UniProt;curated15302935; 16381945; 23193290; 15125835; 18988627; 22135298;
638RIPSDMASPEPEGSQdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated15125835; 16381945; 23193290; 22135298; 22817900
664SWEPRRASTAFCPPAcurated25627689
665WEPRRASTAFCPPAAcurated25627689
794LEMLVPSTPTSTSGAdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated15125835; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)		MLIKEYHILL PMSLDEYQVA QLYMIQKKSR EESSGEGSGV EILANRPYTD GPGGSGQYTH 60
KVYHVGSHIP GWFRALLPKA ALQVEEESWN AYPYTRTRYT CPFVEKFSIE IETYYLPDGG 120
QQPNVFNLSG AERRQRILDT IDIVRDAVAP GEYKAEEDPR LYHSVKTGRG PLSDDWARTA 180
AQTGPLMCAY KLCKVEFRYW GMQAKIEQFI HDVGLRRVML RAHRQAWCWQ DEWTELSMAD 240
IRALEEETAR MLAQRMAKCN TGSEGSEAQP PGKPSTEARS AASNTGTPDG PEAPPGPDAS 300
PDASFGKQWS SSSRSSYSSQ HGGAVSPQSL SEWRMQNIAR DSENSSEEEF FDAHEGFSDS 360
EEVFPKEMTK WNSNDFIDAF ASPVEAEGTP EPGAEAAKGI EDGAQAPRDS EGLDGAGELG 420
AEACAVHALF LILHSGNILD SGPGDANSKQ ADVQTLSSAF EAVTRIHFPE ALGHVALRLV 480
PCPPICAAAY ALVSNLSPYS HDGDSLSRSQ DHIPLAALPL LATSSSRYQG AVATVIARTN 540
QAYSAFLRSP EGAGFCGQVA LIGDGVGGIL GFDALCHSAN AGTGSRGSSR RGSMNNELLS 600
PEFGPVRDPL ADGVEGLGRG SPEPSALPPQ RIPSDMASPE PEGSQNSLQA APATTSSWEP 660
RRASTAFCPP AASSEAPDGP SSTARLDFKV SGFFLFGSPL GLVLALRKTV MPALEAAQMR 720
PACEQIYNLF HAADPCASRL EPLLAPKFQA IAPLTVPRYQ KFPLGDGSSL LLADTLQTHS 780
SLFLEELEML VPSTPTSTSG AFWKGSELAT DPPAQPAAPS TTSEVVKILE RWWGTKRIDY 840
SLYCPEALTA FPTVTLPHLF HASYWESADV VAFILRQVIE KERPQLAECE EPSIYSPAFP 900
REKWQRKRTQ VKIRNVTSNH RASDTVVCEG RPQVLSGRFM YGPLDVVTLT GEKVDVYIMT 960
QPLSGKWIHF GTEVTNSSGR LTFPVPPERA LGIGVYPVRM VVRGDHTYAE CCLTVVARGT 1020
EAVVFSIDGS FTASVSIMGS DPKVRAGAVD VVRHWQDSGY LIVYVTGRPD MQKHRVVAWL 1080
SQHNFPHGVV SFCDGLTHDP LRQKAMFLQS LVQEVELNIV AGYGSPKDVA VYAALGLSPS 1140
QTYIVGRAVR KLQAQCQFLS DGYVAHLGQL EAGSHSHASS GPPRAALGKS SYGVAAPVDF 1200
LRKQSQLLRS RGPSQAEREG PGTPPTTLAR GKARSISLKL DSEE 1245
Keyword

KW-0025--Alternative splicing
KW-0106--Calcium
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0551--Lipid droplet
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
Interpro

IPR004177--DDHD_dom
IPR023214--HAD-like_dom
IPR031315--LNS2/PITP
IPR001666--PI_transfer
IPR023393--START-like_dom
PROSITE

PS51043--DDHD
Pfam

PF02862--DDHD
PF02121--IP_trans
Gene Ontology

GO:0032154--C:cleavage furrow
GO:0005737--C:cytoplasm
GO:0005789--C:endoplasmic reticulum membrane
GO:0032580--C:Golgi cisterna membrane
GO:0005811--C:lipid particle
GO:0016020--C:membrane
GO:0030496--C:midbody
GO:0046872--F:metal ion binding
GO:0008526--F:phosphatidylinositol transporter activity
GO:0007420--P:brain development
GO:0006629--P:lipid metabolic process
GO:0015914--P:phospholipid transport
GO:0007602--P:phototransduction
GO:0015031--P:protein transport