dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000129
Uniprot Accession O00560; SDCB1_HUMAN; B2R5Q7; B4DUH3; B7ZLN2; O00173; O43391; Q14CP2;
Genbank Protein ID NP_001007068.1; NP_001007069.1; NP_001007070.1; NP_001007071.1; NP_005616.2;
Genbank Nucleotide ID NM_001007067.1; NM_001007068.1; NM_001007069.1; NM_001007070.1; NM_005625.3;
Protein Name Syntenin-1
Protein Synonyms/Alias Melanoma differentiation-associated protein 9;MDA-9;Pro-TGF-alpha cytoplasmic domain-interacting protein 18;TACIP18;Scaffold protein Pbp1;Syndecan-binding protein 1;
Gene Name SDCBP
Gene Synonyms/Alias MDA9;SYCL;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.
Phosphorylation Sites
 dbPAF PTMs: 16
PositionPeptidesSourceReferences ( PMIDs )
2------MSLYPSLEDdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 23186163
4----MSLYPSLEDLKdbPTM 3.0;PhosphoSitePlus;curated22349701; 16381945; 23193290; 22135298; 25627689
6--MSLYPSLEDLKVDdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19413330; 16381945; 23193290; 18578522; 21949238; 22115753;
33PANPAILSEASAPIPPhosphoSitePlus22135298
36PAILSEASAPIPHDGPhosphoPep 2.0;PhosphoSitePlus19060867; 22135298
46IPHDGNLYPRLYPELdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated18083107; 16381945; 23193290; 17360941; 18180459; 20736484;
50GNLYPRLYPELSQYMdbPTM 3.0;PhosphoSitePlus;curated20736484; 22349701; 16381945; 23193290; 22135298; 25142963;
54PRLYPELSQYMGLSLdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus19007248; 16381945; 23193290; 19060867; 22135298
56LYPELSQYMGLSLNEdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated18083107; 18180459; 19605366; 20562096; 21253578; 22349701;
60LSQYMGLSLNEEEIRdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus19007248; 16381945; 23193290; 18988627; 19060867; 22135298
88QLVARPSSINYMVAPcurated20071362
91ARPSSINYMVAPVTGdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 17360941; 21253578; 18988627;
131KIGLRLKSIDNGIFVcurated25850435
187QAFGEKITMTIRDRPdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627; 22817900
200RPFERTITMHKDSTGdbPTM 3.020068231; 16381945; 23193290
206ITMHKDSTGHVGFIFdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
Sequence
(Fasta)		MSLYPSLEDL KVDKVIQAQT AFSANPANPA ILSEASAPIP HDGNLYPRLY PELSQYMGLS 60
LNEEEIRANV AVVSGAPLQG QLVARPSSIN YMVAPVTGND VGIRRAEIKQ GIREVILCKD 120
QDGKIGLRLK SIDNGIFVQL VQANSPASLV GLRFGDQVLQ INGENCAGWS SDKAHKVLKQ 180
AFGEKITMTI RDRPFERTIT MHKDSTGHVG FIFKNGKITS IVKDSSAARN GLLTEHNICE 240
INGQNVIGLK DSQIADILST SGTVVTITIM PAFIFEHIIK RMAPSIMKSL MDHTIPEV 299
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR001478--PDZ
IPR030528--SDCBP
PROSITE

PS50106--PDZ
Pfam

PF00595--PDZ
Gene Ontology

GO:0005912--C:adherens junction
GO:0072562--C:blood microparticle
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:1903561--C:extracellular vesicle
GO:0005925--C:focal adhesion
GO:0005895--C:interleukin-5 receptor complex
GO:0042470--C:melanosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0008093--F:cytoskeletal adaptor activity
GO:0005109--F:frizzled binding
GO:0042802--F:identical protein binding
GO:0005137--F:interleukin-5 receptor binding
GO:0046982--F:protein heterodimerization activity
GO:0047485--F:protein N-terminus binding
GO:0045545--F:syndecan binding
GO:0030036--P:actin cytoskeleton organization
GO:0007411--P:axon guidance
GO:0048013--P:ephrin receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:1903543--P:positive regulation of exosomal secretion
GO:1903553--P:positive regulation of extracellular exosome assembly
GO:0046330--P:positive regulation of JNK cascade
GO:0042327--P:positive regulation of phosphorylation
GO:0006612--P:protein targeting to membrane
GO:0007265--P:Ras protein signal transduction
GO:0006930--P:substrate-dependent cell migration, cell extension
GO:0007268--P:synaptic transmission