dbPAF - database of Phospho-sites in Animals and Fungi

Protein
Gene
PTMs
Sequence
Keyword
GO
TOP

dbPAF Protein Information

Tag

Content

dbPAF ID

dbPAF-0000127

Uniprot Accession

O00555; CAC1A_HUMAN; J3KP41; P78510; P78511; Q16290; Q92690; Q99790; Q99791; Q99792; Q99793; Q9NS88; Q9UDC4;

Genbank Protein ID

NP_000059.3; NP_001120693.1; NP_001120694.1; NP_001167551.1; NP_075461.2;

Genbank Nucleotide ID

NM_000068.3; NM_001127221.1; NM_001127222.1; NM_001174080.1; NM_023035.2;

Protein Name

Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Protein Synonyms/Alias

Brain calcium channel I;BI;Calcium channel, L type, alpha-1 polypeptide isoform 4;Voltage-gated calcium channel subunit alpha Cav2.1;

Gene Name

CACNA1A

Gene Synonyms/Alias

CACH4;CACN3;CACNL1A4;

Organism

Homo sapiens(Human)

NCBI Taxa ID

9606

Functional Description
(View all)

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).

Phosphorylation Sites

dbPAF PTMs: 22 (View all)

Position	Peptides	Source	References ( PMIDs )
12	GDEMPARYGGGGSGA	PhosphoSitePlus	22135298
211	KLVSGIPSLQVVLKS	PhosphoSitePlus	22135298
910	DHHAREGSLEQPGFW	PhosphoSitePlus	22135298
947	SRESRSGSPRTGADG	PhosphoSitePlus;curated	22135298; 22817900
1014	RHGAPATYEGDARRE	dbPTM 3.0;PhosphoSitePlus;curated	18083107; 16381945; 23193290; 22135298; 22817900
1122	TNPQNAASRRTPNNP	PhosphoSitePlus	22135298
1421	EKDCRGKYLLYEKNE	dbPTM 3.0;PhosphoSitePlus;curated	18083107; 16381945; 23193290; 22135298; 22817900
1424	CRGKYLLYEKNEVKA	dbPTM 3.0;PhosphoSitePlus;curated	18083107; 16381945; 23193290; 22135298; 22817900
1935	MAIWPNLSQKTLDLL	PhosphoSitePlus	22135298
2115	PRGNNLSTISDTSPM	PhosphoSitePlus	22135298
2117	GNNLSTISDTSPMKR	PhosphoSitePlus	22135298
2119	NLSTISDTSPMKRSA	PhosphoSitePlus	22135298
2120	LSTISDTSPMKRSAS	PhosphoSitePlus	22135298
2125	DTSPMKRSASVLGPK	PhosphoSitePlus	22135298
2127	SPMKRSASVLGPKAR	PhosphoSitePlus	22135298
2140	ARRLDDYSLERVPPE	curated	23186163
2263	HMAHRQGSSSVSGSP	PhosphoSitePlus	22135298
2265	AHRQGSSSVSGSPAP	PhosphoSitePlus	22135298
2267	RQGSSSVSGSPAPST	PhosphoSitePlus	22135298
2274	SGSPAPSTSGTSTPR	PhosphoSitePlus	22135298

Sequence
(Fasta)

MARFGDEMPA RYGGGGSGAA AGVVVGSGGG RGAGGSRQGG QPGAQRMYKQ SMAQRARTMA 60
LYNPIPVRQN CLTVNRSLFL FSEDNVVRKY AKKITEWPPF EYMILATIIA NCIVLALEQH 120
LPDDDKTPMS ERLDDTEPYF IGIFCFEAGI KIIALGFAFH KGSYLRNGWN VMDFVVVLTG 180
ILATVGTEFD LRTLRAVRVL RPLKLVSGIP SLQVVLKSIM KAMIPLLQIG LLLFFAILIF 240
AIIGLEFYMG KFHTTCFEEG TDDIQGESPA PCGTEEPART CPNGTKCQPY WEGPNNGITQ 300
FDNILFAVLT VFQCITMEGW TDLLYNSNDA SGNTWNWLYF IPLIIIGSFF MLNLVLGVLS 360
GEFAKERERV ENRRAFLKLR RQQQIERELN GYMEWISKAE EVILAEDETD GEQRHPFDGA 420
LRRTTIKKSK TDLLNPEEAE DQLADIASVG SPFARASIKS AKLENSTFFH KKERRMRFYI 480
RRMVKTQAFY WTVLSLVALN TLCVAIVHYN QPEWLSDFLY YAEFIFLGLF MSEMFIKMYG 540
LGTRPYFHSS FNCFDCGVII GSIFEVIWAV IKPGTSFGIS VLRALRLLRI FKVTKYWASL 600
RNLVVSLLNS MKSIISLLFL LFLFIVVFAL LGMQLFGGQF NFDEGTPPTN FDTFPAAIMT 660
VFQILTGEDW NEVMYDGIKS QGGVQGGMVF SIYFIVLTLF GNYTLLNVFL AIAVDNLANA 720
QELTKDEQEE EEAANQKLAL QKAKEVAEVS PLSAANMSIA VKEQQKNQKP AKSVWEQRTS 780
EMRKQNLLAS REALYNEMDP DERWKAAYTR HLRPDMKTHL DRPLVVDPQE NRNNNTNKSR 840
AAEPTVDQRL GQQRAEDFLR KQARYHDRAR DPSGSAGLDA RRPWAGSQEA ELSREGPYGR 900
ESDHHAREGS LEQPGFWEGE AERGKAGDPH RRHVHRQGGS RESRSGSPRT GADGEHRRHR 960
AHRRPGEEGP EDKAERRARH REGSRPARGG EGEGEGPDGG ERRRRHRHGA PATYEGDARR 1020
EDKERRHRRR KENQGSGVPV SGPNLSTTRP IQQDLGRQDP PLAEDIDNMK NNKLATAESA 1080
APHGSLGHAG LPQSPAKMGN STDPGPMLAI PAMATNPQNA ASRRTPNNPG NPSNPGPPKT 1140
PENSLIVTNP SGTQTNSAKT ARKPDHTTVD IPPACPPPLN HTVVQVNKNA NPDPLPKKEE 1200
EKKEEEEDDR GEDGPKPMPP YSSMFILSTT NPLRRLCHYI LNLRYFEMCI LMVIAMSSIA 1260
LAAEDPVQPN APRNNVLRYF DYVFTGVFTF EMVIKMIDLG LVLHQGAYFR DLWNILDFIV 1320
VSGALVAFAF TGNSKGKDIN TIKSLRVLRV LRPLKTIKRL PKLKAVFDCV VNSLKNVFNI 1380
LIVYMLFMFI FAVVAVQLFK GKFFHCTDES KEFEKDCRGK YLLYEKNEVK ARDREWKKYE 1440
FHYDNVLWAL LTLFTVSTGE GWPQVLKHSV DATFENQGPS PGYRMEMSIF YVVYFVVFPF 1500
FFVNIFVALI IITFQEQGDK MMEEYSLEKN ERACIDFAIS AKPLTRHMPQ NKQSFQYRMW 1560
QFVVSPPFEY TIMAMIALNT IVLMMKFYGA SVAYENALRV FNIVFTSLFS LECVLKVMAF 1620
GILNYFRDAW NIFDFVTVLG SITDILVTEF GNNFINLSFL RLFRAARLIK LLRQGYTIRI 1680
LLWTFVQSFK ALPYVCLLIA MLFFIYAIIG MQVFGNIGID VEDEDSDEDE FQITEHNNFR 1740
TFFQALMLLF RSATGEAWHN IMLSCLSGKP CDKNSGILTR ECGNEFAYFY FVSFIFLCSF 1800
LMLNLFVAVI MDNFEYLTRD SSILGPHHLD EYVRVWAEYD PAAWGRMPYL DMYQMLRHMS 1860
PPLGLGKKCP ARVAYKRLLR MDLPVADDNT VHFNSTLMAL IRTALDIKIA KGGADKQQMD 1920
AELRKEMMAI WPNLSQKTLD LLVTPHKSTD LTVGKIYAAM MIMEYYRQSK AKKLQAMREE 1980
QDRTPLMFQR MEPPSPTQEG GPGQNALPST QLDPGGALMA HESGLKESPS WVTQRAQEMF 2040
QKTGTWSPEQ GPPTDMPNSQ PNSQSVEMRE MGRDGYSDSE HYLPMEGQGR AASMPRLPAE 2100
NQRRRGRPRG NNLSTISDTS PMKRSASVLG PKARRLDDYS LERVPPEENQ RHHQRRRDRS 2160
HRASERSLGR YTDVDTGLGT DLSMTTQSGD LPSKERDQER GRPKDRKHRQ HHHHHHHHHH 2220
PPPPDKDRYA QERPDHGRAR ARDQRWSRSP SEGREHMAHR QGSSSVSGSP APSTSGTSTP 2280
RRGRRQLPQT PSTPRPHVSY SPVIRKAGGS GPPQQQQQQQ QQQQAVARPG RAATSGPRRY 2340
PGPTAEPLAG DRPPTGGHSS GRSPRMERRV PGPARSESPR ACRHGGARWP ASGPHVSEGP 2400
PGPRHHGYYR GSDYDEADGP GSGGGEEAMA GAYDAPPPVR HASSGATGRS PRTPRASGPA 2460
CASPSRHGRR LPNGYYPAHG LARPRGPGSR KGLHEPYSES DDDWC 2506

Fasta Sequence

>O00555|CACNA1A|Homo sapiens(Human)
MARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENRNNNTNKSRAAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARRPWAGSQEAELSREGPYGRESDHHAREGSLEQPGFWEGEAERGKAGDPHRRHVHRQGGSRESRSGSPRTGADGEHRRHRAHRRPGEEGPEDKAERRARHREGSRPARGGEGEGEGPDGGERRRRHRHGAPATYEGDARREDKERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDIDNMKNNKLATAESAAPHGSLGHAGLPQSPAKMGNSTDPGPMLAIPAMATNPQNAASRRTPNNPGNPSNPGPPKTPENSLIVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQDRTPLMFQRMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKESPSWVTQRAQEMFQKTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPAENQRRRGRPRGNNLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRHHQRRRDRSHRASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQERGRPKDRKHRQHHHHHHHHHHPPPPDKDRYAQERPDHGRARARDQRWSRSPSEGREHMAHRQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPSTPRPHVSYSPVIRKAGGSGPPQQQQQQQQQQQAVARPGRAATSGPRRYPGPTAEPLAGDRPPTGGHSSGRSPRMERRVPGPARSESPRACRHGGARWPASGPHVSEGPPGPRHHGYYRGSDYDEADGPGSGGGEEAMAGAYDAPPPVRHASSGATGRSPRTPRASGPACASPSRHGRRLPNGYYPAHGLARPRGPGSRKGLHEPYSESDDDWC

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0106--Calcium
KW-0107--Calcium channel
KW-0109--Calcium transport
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0407--Ion channel
KW-0406--Ion transport
KW-0472--Membrane
KW-0479--Metal-binding
KW-0523--Neurodegeneration
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0950--Spinocerebellar ataxia
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
KW-0818--Triplet repeat expansion
KW-0851--Voltage-gated channel

Interpro

IPR005448--CACNA1A
IPR027359--Channel_four-helix_dom
IPR031649--GPHH_dom
IPR005821--Ion_trans_dom
IPR014873--VDCC_a1su_IQ
IPR002077--VDCCAlpha1

PROSITE

Pfam

PF08763--Ca_chan_IQ
PF16905--GPHH
PF00520--Ion_trans

Gene Ontology

GO:0042995--C:cell projection
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0016021--C:integral component of membrane
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005891--C:voltage-gated calcium channel complex
GO:0008331--F:high voltage-gated calcium channel activity
GO:0046872--F:metal ion binding
GO:0019905--F:syntaxin binding
GO:0005245--F:voltage-gated calcium channel activity
GO:0007628--P:adult walking behavior
GO:0048266--P:behavioral response to pain
GO:0070509--P:calcium ion import
GO:0006816--P:calcium ion transport
GO:0017156--P:calcium ion-dependent exocytosis
GO:0048791--P:calcium ion-dependent exocytosis of neurotransmitter
GO:0008219--P:cell death
GO:0016049--P:cell growth
GO:0030644--P:cellular chloride ion homeostasis
GO:0021679--P:cerebellar molecular layer development
GO:0021702--P:cerebellar Purkinje cell differentiation
GO:0021590--P:cerebellum maturation
GO:0048813--P:dendrite morphogenesis
GO:0006112--P:energy reserve metabolic process
GO:0014051--P:gamma-aminobutyric acid secretion
GO:0007214--P:gamma-aminobutyric acid signaling pathway
GO:0006006--P:glucose metabolic process
GO:0042445--P:hormone metabolic process
GO:0034220--P:ion transmembrane transport
GO:0051899--P:membrane depolarization
GO:0086010--P:membrane depolarization during action potential
GO:0050883--P:musculoskeletal movement, spinal reflex action
GO:0032353--P:negative regulation of hormone biosynthetic process
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0050885--P:neuromuscular process controlling balance
GO:0007274--P:neuromuscular synaptic transmission
GO:0042133--P:neurotransmitter metabolic process
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0043113--P:receptor clustering
GO:0014056--P:regulation of acetylcholine secretion, neurotransmission
GO:0050770--P:regulation of axonogenesis
GO:0017158--P:regulation of calcium ion-dependent exocytosis
GO:0050796--P:regulation of insulin secretion
GO:0060024--P:rhythmic synaptic transmission
GO:0044281--P:small molecule metabolic process
GO:0021522--P:spinal cord motor neuron differentiation
GO:0000096--P:sulfur amino acid metabolic process
GO:0007416--P:synapse assembly
GO:0007268--P:synaptic transmission
GO:0035249--P:synaptic transmission, glutamatergic
GO:0019226--P:transmission of nerve impulse
GO:0021750--P:vestibular nucleus development