Tag |
Content |
dbPAF ID |
dbPAF-0000125 |
Uniprot Accession |
O00541; PESC_HUMAN; Q6IC29; |
Genbank Protein ID |
NP_001230154.1; NP_055118.1; |
Genbank Nucleotide ID |
NM_001243225.1; NM_014303.3; |
Protein Name |
Pescadillo homolog |
Protein Synonyms/Alias |
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Gene Name |
PES1 |
Gene Synonyms/Alias |
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Organism |
Homo sapiens(Human) |
NCBI Taxa ID |
9606 |
Functional Description (View all) |
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.Functional Description
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
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Phosphorylation Sites
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dbPAF PTMs: 17 |
Sequence (Fasta) | MGGLEKKKYE RGSATNYITR NKARKKLQLS LADFRRLCIL KGIYPHEPKH KKKVNKGSTA 60 ARTFYLIKDI RFLLHEPIVN KFREYKVFVR KLRKAYGKSE WNTVERLKDN KPNYKLDHII 120 KERYPTFIDA LRDLDDALSM CFLFSTFPRT GKCHVQTIQL CRRLTVEFMH YIIAARALRK 180 VFLSIKGIYY QAEVLGQPIV WITPYAFSHD HPTDVDYRVM ATFTEFYTTL LGFVNFRLYQ 240 LLNLHYPPKL EGQAQAEAKA GEGTYALDSE SCMEKLAALS ASLARVVVPA TEEEAEVDEF 300 PTDGEMSAQE EDRRKELEAQ EKHKKLFEGL KFFLNREVPR EALAFIIRSF GGEVSWDKSL 360 CIGATYDVTD SRITHQIVDR PGQQTSVIGR CYVQPQWVFD SVNARLLLPV AEYFSGVQLP 420 PHLSPFVTEK EGDYVPPEKL KLLALQRGED PGNLNESEEE EEEDDNNEGD GDEEGENEEE 480 EEDAEAGSEK EEEARLAALE EQRMEGKKPR VMAGTLKLED KQRLAQEEES EAKRLAIMMM 540 KKREKYLYQK IMFGKRRKIR EANKLAEKRK AHDEAVRSEK KAKKARPE
589Fasta Sequence
>O00541|PES1|Homo sapiens(Human) MGGLEKKKYERGSATNYITRNKARKKLQLSLADFRRLCILKGIYPHEPKHKKKVNKGSTAARTFYLIKDIRFLLHEPIVNKFREYKVFVRKLRKAYGKSEWNTVERLKDNKPNYKLDHIIKERYPTFIDALRDLDDALSMCFLFSTFPRTGKCHVQTIQLCRRLTVEFMHYIIAARALRKVFLSIKGIYYQAEVLGQPIVWITPYAFSHDHPTDVDYRVMATFTEFYTTLLGFVNFRLYQLLNLHYPPKLEGQAQAEAKAGEGTYALDSESCMEKLAALSASLARVVVPATEEEAEVDEFPTDGEMSAQEEDRRKELEAQEKHKKLFEGLKFFLNREVPREALAFIIRSFGGEVSWDKSLCIGATYDVTDSRITHQIVDRPGQQTSVIGRCYVQPQWVFDSVNARLLLPVAEYFSGVQLPPHLSPFVTEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREANKLAEKRKAHDEAVRSEKKAKKARPE
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Keyword |
KW-0002--3D-structure KW-0007--Acetylation KW-0025--Alternative splicing KW-0158--Chromosome KW-0181--Complete proteome KW-0539--Nucleus KW-0621--Polymorphism KW-1185--Reference proteome KW-0690--Ribosome biogenesis KW-0698--rRNA processing KW-0832--Ubl conjugation
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Interpro |
IPR001357--BRCT_dom IPR010613--PES
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PROSITE |
PS50172--BRCT
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Pfam |
PF16589--BRCT_2 PF06732--Pescadillo_N
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Gene Ontology |
GO:0000793--C:condensed chromosome GO:0005737--C:cytoplasm GO:0016020--C:membrane GO:0005730--C:nucleolus GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0070545--C:PeBoW complex GO:0030687--C:preribosome, large subunit precursor GO:0044822--F:poly(A) RNA binding GO:0043021--F:ribonucleoprotein complex binding GO:0008283--P:cell proliferation GO:0000466--P:maturation of 5 8S rRNA fr--m tricistronic rRNA transcript (SSU-rRNA, 5 8S rRNA, L--U-rRNA) GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5 8S rRNA, L--U-rRNA) GO:0007000--P:nucleolus organization GO:0033365--P:protein localization to organelle GO:0051726--P:regulation of cell cycle GO:0042273--P:ribosomal large subunit biogenesis GO:0006364--P:rRNA processing
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