dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000125
Uniprot Accession O00541; PESC_HUMAN; Q6IC29;
Genbank Protein ID NP_001230154.1; NP_055118.1;
Genbank Nucleotide ID NM_001243225.1; NM_014303.3;
Protein Name Pescadillo homolog
Protein Synonyms/Alias
Gene Name PES1
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Phosphorylation Sites
dbPAF PTMs: 17
PositionPeptidesSourceReferences ( PMIDs )
13KKKYERGSATNYITRdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19691289; 16381945; 23193290; 18988627; 22135298; 25627689
15KYERGSATNYITRNKdbPTM 3.0;HPRD 9;curated19691289; 16381945; 23193290; 18988627
30ARKKLQLSLADFRRLPhosphoSitePlus22135298
65STAARTFYLIKDIRFdbPTM 3.0;PhosphoSitePlus19835603; 16381945; 23193290; 22135298
265AKAGEGTYALDSESCPhosphoSitePlus22135298
280MEKLAALSASLARVVcurated25003641
282KLAALSASLARVVVPcurated25003641
302AEVDEFPTDGEMSAQPhosphoSitePlus22135298
307FPTDGEMSAQEEDRRPhosphoSitePlus;curated22135298; 25627689; 23898821; 20873877
359GEVSWDKSLCIGATYPhosphoSitePlus22135298
434VTEKEGDYVPPEKLKPhosphoSitePlus;curated22135298; 25627689
457DPGNLNESEEEEEEDdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 21659604; 18988627; 22135298;
488EEDAEAGSEKEEEARdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 21659604; 18988627; 22135298;
515KPRVMAGTLKLEDKQPhosphoSitePlus22135298
530RLAQEEESEAKRLAIPhosphoSitePlus;curated22135298; 25627689
548KKREKYLYQKIMFGKdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus18083107; 16381945; 23193290; 18988627; 22135298
578AHDEAVRSEKKAKKAdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298;
Sequence
(Fasta)
MGGLEKKKYE RGSATNYITR NKARKKLQLS LADFRRLCIL KGIYPHEPKH KKKVNKGSTA 60
ARTFYLIKDI RFLLHEPIVN KFREYKVFVR KLRKAYGKSE WNTVERLKDN KPNYKLDHII 120
KERYPTFIDA LRDLDDALSM CFLFSTFPRT GKCHVQTIQL CRRLTVEFMH YIIAARALRK 180
VFLSIKGIYY QAEVLGQPIV WITPYAFSHD HPTDVDYRVM ATFTEFYTTL LGFVNFRLYQ 240
LLNLHYPPKL EGQAQAEAKA GEGTYALDSE SCMEKLAALS ASLARVVVPA TEEEAEVDEF 300
PTDGEMSAQE EDRRKELEAQ EKHKKLFEGL KFFLNREVPR EALAFIIRSF GGEVSWDKSL 360
CIGATYDVTD SRITHQIVDR PGQQTSVIGR CYVQPQWVFD SVNARLLLPV AEYFSGVQLP 420
PHLSPFVTEK EGDYVPPEKL KLLALQRGED PGNLNESEEE EEEDDNNEGD GDEEGENEEE 480
EEDAEAGSEK EEEARLAALE EQRMEGKKPR VMAGTLKLED KQRLAQEEES EAKRLAIMMM 540
KKREKYLYQK IMFGKRRKIR EANKLAEKRK AHDEAVRSEK KAKKARPE 589
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0832--Ubl conjugation

Interpro

IPR001357--BRCT_dom
IPR010613--PES

PROSITE

PS50172--BRCT

Pfam

PF16589--BRCT_2
PF06732--Pescadillo_N

Gene Ontology

GO:0000793--C:condensed chromosome
GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0070545--C:PeBoW complex
GO:0030687--C:preribosome, large subunit precursor
GO:0044822--F:poly(A) RNA binding
GO:0043021--F:ribonucleoprotein complex binding
GO:0008283--P:cell proliferation
GO:0000466--P:maturation of 5
8S rRNA fr--m tricistronic rRNA transcript (SSU-rRNA, 5
8S rRNA, L--U-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5
8S rRNA, L--U-rRNA)
GO:0007000--P:nucleolus organization
GO:0033365--P:protein localization to organelle
GO:0051726--P:regulation of cell cycle
GO:0042273--P:ribosomal large subunit biogenesis
GO:0006364--P:rRNA processing