dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000123
Uniprot Accession O00533; NCHL1_HUMAN; B7ZL03; Q2M3G2; Q59FY0;
Genbank Protein ID NP_001240316.1; NP_006605.2; XP_006713001.1; XP_006713002.1; XP_006713003.1; XP_011531594.1; XP_011531595.1; XP_011531596.1; XP_011531597.1;
Genbank Nucleotide ID NM_001253387.1; NM_006614.3; XM_006712938.1; XM_006712939.2; XM_006712940.2; XM_011533292.1; XM_011533293.1; XM_011533294.1; XM_011533295.1;
Protein Name Neural cell adhesion molecule L1-like protein
Protein Synonyms/Alias Close homolog of L1;
Gene Name CHL1
Gene Synonyms/Alias CALL;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 15
PositionPeptidesSourceReferences ( PMIDs )
213AAFPRLRTIVQKMPMPhosphoSitePlus22135298
291GRETKENYGKTLKIEdbPTM 3.0;PhosphoSitePlus18083107; 16381945; 23193290; 22135298
747QNGPGLEYRVTWKPQPhosphoSitePlus22135298
778RVMTPAVYAPYDVKVPhosphoSitePlus22135298
871EVNILRFSGQRNSGMPhosphoSitePlus22135298
876RFSGQRNSGMVPSLDPhosphoSitePlus22135298
933KVDKDTATLSWGLPKPhosphoSitePlus22135298
935DKDTATLSWGLPKKLPhosphoSitePlus22135298
953LTGYLLQYQIINDTYPhosphoSitePlus22135298
971ELNDINITTPSKPSWPhosphoSitePlus22135298
1057KNWGDNDSIFQDVIEcurated26074081
1127HPDPEIQSVKDETFGdbPTM 3.0;PhosphoSitePlus;curated20164059; 16381945; 23193290; 22135298; 23898821
1147DEKPLKGSLRSLNRDdbPTM 3.0;PhosphoSitePlus;curated20164059; 16381945; 23193290; 22135298; 23898821
1150PLKGSLRSLNRDMQPdbPTM 3.0;PhosphoSitePlus;curated20164059; 16381945; 23193290; 22135298; 23898821
1180GLFSEDGSFIGAYAGPhosphoSitePlus22135298
Sequence
(Fasta)		MEPLLLGRGL IVYLMFLLLK FSKAIEIPSS VQQVPTIIKQ SKVQVAFPFD EYFQIECEAK 60
GNPEPTFSWT KDGNPFYFTD HRIIPSNNSG TFRIPNEGHI SHFQGKYRCF ASNKLGIAMS 120
EEIEFIVPSV PKFPKEKIDP LEVEEGDPIV LPCNPPKGLP PLHIYWMNIE LEHIEQDERV 180
YMSQKGDLYF ANVEEKDSRN DYCCFAAFPR LRTIVQKMPM KLTVNSSNSI KQRKPKLLLP 240
PTESGSESSI TILKGEILLL ECFAEGLPTP QVDWNKIGGD LPKGRETKEN YGKTLKIENV 300
SYQDKGNYRC TASNFLGTAT HDFHVIVEEP PRWTKKPQSA VYSTGSNGIL LCEAEGEPQP 360
TIKWRVNGSP VDNHPFAGDV VFPREISFTN LQPNHTAVYQ CEASNVHGTI LANANIDVVD 420
VRPLIQTKDG ENYATVVGYS AFLHCEFFAS PEAVVSWQKV EEVKPLEGRR YHIYENGTLQ 480
INRTTEEDAG SYSCWVENAI GKTAVTANLD IRNATKLRVS PKNPRIPKLH MLELHCESKC 540
DSHLKHSLKL SWSKDGEAFE INGTEDGRII IDGANLTISN VTLEDQGIYC CSAHTALDSA 600
ADITQVTVLD VPDPPENLHL SERQNRSVRL TWEAGADHNS NISEYIVEFE GNKEEPGRWE 660
ELTRVQGKKT TVILPLAPFV RYQFRVIAVN EVGRSQPSQP SDHHETPPAA PDRNPQNIRV 720
QASQPKEMII KWEPLKSMEQ NGPGLEYRVT WKPQGAPVEW EEETVTNHTL RVMTPAVYAP 780
YDVKVQAINQ LGSGPDPQSV TLYSGEDYPD TAPVIHGVDV INSTLVKVTW STVPKDRVHG 840
RLKGYQINWW KTKSLLDGRT HPKEVNILRF SGQRNSGMVP SLDAFSEFHL TVLAYNSKGA 900
GPESEPYIFQ TPEGVPEQPT FLKVIKVDKD TATLSWGLPK KLNGNLTGYL LQYQIINDTY 960
EIGELNDINI TTPSKPSWHL SNLNATTKYK FYLRACTSQG CGKPITEESS TLGEGSKGIG 1020
KISGVNLTQK THPIEVFEPG AEHIVRLMTK NWGDNDSIFQ DVIETRGREY AGLYDDISTQ 1080
GWFIGLMCAI ALLTLLLLTV CFVKRNRGGK YSVKEKEDLH PDPEIQSVKD ETFGEYSDSD 1140
EKPLKGSLRS LNRDMQPTES ADSLVEYGEG DHGLFSEDGS FIGAYAGSKE KGSVESNGSS 1200
TATFPLRA 1209
Keyword

KW-0025--Alternative splicing
KW-0130--Cell adhesion
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-1015--Disulfide bond
KW-0272--Extracellular matrix
KW-0325--Glycoprotein
KW-0393--Immunoglobulin domain
KW-0472--Membrane
KW-0524--Neurogenesis
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR003961--FN3_dom
IPR007110--Ig-like_dom
IPR013783--Ig-like_fold
IPR013098--Ig_I-set
IPR003599--Ig_sub
IPR003598--Ig_sub2
IPR026966--Neurofascin/L1/NrCAM_C
PROSITE

PS50853--FN3
PS50835--IG_LIKE
Pfam

PF13882--Bravo_FIGEY
PF00041--fn3
PF07679--I-set
Gene Ontology

GO:0045177--C:apical part of cell
GO:0030425--C:dendrite
GO:0070062--C:extracellular exosome
GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0005578--C:proteinaceous extracellular matrix
GO:0008344--P:adult locomotory behavior
GO:0007411--P:axon guidance
GO:0031103--P:axon regeneration
GO:0007155--P:cell adhesion
GO:0050890--P:cognition
GO:0035640--P:exploration behavior
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0001764--P:neuron migration
GO:0007165--P:signal transduction