dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000121
Uniprot Accession O00519; FAAH1_HUMAN; D3DQ19; Q52M86; Q5TDF8;
Genbank Protein ID NP_001432.2;
Genbank Nucleotide ID NM_001441.2;
Protein Name Fatty-acid amide hydrolase 1
Protein Synonyms/Alias Anandamide amidohydrolase 1;Oleamide hydrolase 1;
Gene Name FAAH
Gene Synonyms/Alias FAAH1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
88QLVQKLHSRELAPEAPhosphoSitePlus22135298
99APEAVLFTYVGKAWEdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20058876; 16381945; 23193290; 18988627; 22135298; 22817900
241LGTDIGGSIRFPSSFPhosphoSitePlus;UniProt22135298; 24275569
289PMARDVESLALCLRAPhosphoSitePlus;curated22135298; 24667141
329SQPLRVGYYETDNYTdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 18988627; 19060867; 22135298;
335GYYETDNYTMPSPAMdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 18988627; 19060867; 22135298;
430KPLLPRLSAFLSNMKPhosphoSitePlus22135298
434PRLSAFLSNMKSRSAPhosphoSitePlus22135298
440LSNMKSRSAGKLWELPhosphoSitePlus22135298
454LQHEIEVYRKTVIAQPhosphoSitePlus22135298
Sequence
(Fasta)		MVQYELWAAL PGASGVALAC CFVAAAVALR WSGRRTARGA VVRARQRQRA GLENMDRAAQ 60
RFRLQNPDLD SEALLALPLP QLVQKLHSRE LAPEAVLFTY VGKAWEVNKG TNCVTSYLAD 120
CETQLSQAPR QGLLYGVPVS LKECFTYKGQ DSTLGLSLNE GVPAECDSVV VHVLKLQGAV 180
PFVHTNVPQS MFSYDCSNPL FGQTVNPWKS SKSPGGSSGG EGALIGSGGS PLGLGTDIGG 240
SIRFPSSFCG ICGLKPTGNR LSKSGLKGCV YGQEAVRLSV GPMARDVESL ALCLRALLCE 300
DMFRLDPTVP PLPFREEVYT SSQPLRVGYY ETDNYTMPSP AMRRAVLETK QSLEAAGHTL 360
VPFLPSNIPH ALETLSTGGL FSDGGHTFLQ NFKGDFVDPC LGDLVSILKL PQWLKGLLAF 420
LVKPLLPRLS AFLSNMKSRS AGKLWELQHE IEVYRKTVIA QWRALDLDVV LTPMLAPALD 480
LNAPGRATGA VSYTMLYNCL DFPAGVVPVT TVTAEDEAQM EHYRGYFGDI WDKMLQKGMK 540
KSVGLPVAVQ CVALPWQEEL CLRFMREVER LMTPEKQSS
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR000120--Amidase
IPR020556--Amidase_CS
IPR023631--Amidase_dom
IPR030560--FAAH
PROSITE

PS00571--AMIDASES
Pfam

PF01425--Amidase
Gene Ontology

GO:0005856--C:cytoskeleton
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0031090--C:organelle membrane
GO:0047372--F:acylglycerol lipase activity
GO:0016884--F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor
GO:0017064--F:fatty acid amide hydrolase activity
GO:0019369--P:arachidonic acid metabolic process
GO:0009062--P:fatty acid catabolic process
GO:0044281--P:small molecule metabolic process