dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000117
Uniprot Accession O00506; STK25_HUMAN; A8K6Z3; A8K7D2; B7Z9K1; Q15522; Q5BJF1;
Genbank Protein ID NP_001258906.1; NP_001258907.1; NP_001258908.1; NP_001258909.1; NP_001269234.1; NP_001269236.1; NP_001269237.1; NP_006365.2;
Genbank Nucleotide ID NM_001271977.1; NM_001271978.1; NM_001271979.1; NM_001271980.1; NM_001282305.1; NM_001282307.1; NM_001282308.1; NM_006374.4;
Protein Name Serine/threonine-protein kinase 25
Protein Synonyms/Alias Ste20-like kinase;Sterile 20/oxidant stress-response kinase 1;SOK-1;Ste20/oxidant stress response kinase 1;
Gene Name STK25
Gene Synonyms/Alias SOK1;YSK1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
12RGFANQHSRVDPEELcurated24961811
30LDRIGKGSFGEVYKGPhosphoSitePlus22135298
35KGSFGEVYKGIDNHTPhosphoSitePlus22135298
97KLWIIMEYLGGGSALPhosphoSitePlus22135298
166FGVAGQLTDTQIKRNdbPTM 3.0;PhosphoSitePlus;curated22322096; 16381945; 23193290; 22135298; 23663014
168VAGQLTDTQIKRNTFdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated17287340; 17525332; 19369195; 16381945; 23193290; 18578522;
174DTQIKRNTFVGTPFWdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated15037601; 19369195; 16381945; 23193290; 19362540; 19690332;
178KRNTFVGTPFWMAPEdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated18669648; 22322096; 16381945; 23193290; 18988627; 22135298;
231LFLIPKNSPPTLEGQPhosphoSitePlus;curated22135298; 25627689; 20873877; 23186163
240PTLEGQHSKPFKEFVcurated23403867
342KGTALHSSQKPAEPVdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated17287340; 16381945; 23193290; 18988627; 22135298; 19366988;
360PRSQCLSTLVRPVFGPhosphoSitePlus22135298
416VERVQRFSHNRNHLTcurated26074081
423SHNRNHLTSTR----curated26074081
Sequence
(Fasta)		MAHLRGFANQ HSRVDPEELF TKLDRIGKGS FGEVYKGIDN HTKEVVAIKI IDLEEAEDEI 60
EDIQQEITVL SQCDSPYITR YFGSYLKSTK LWIIMEYLGG GSALDLLKPG PLEETYIATI 120
LREILKGLDY LHSERKIHRD IKAANVLLSE QGDVKLADFG VAGQLTDTQI KRNTFVGTPF 180
WMAPEVIKQS AYDFKADIWS LGITAIELAK GEPPNSDLHP MRVLFLIPKN SPPTLEGQHS 240
KPFKEFVEAC LNKDPRFRPT AKELLKHKFI TRYTKKTSFL TELIDRYKRW KSEGHGEESS 300
SEDSDIDGEA EDGEQGPIWT FPPTIRPSPH SKLHKGTALH SSQKPAEPVK RQPRSQCLST 360
LVRPVFGELK EKHKQSGGSV GALEELENAF SLAEESCPGI SDKLMVHLVE RVQRFSHNRN 420
HLTSTR 427
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0333--Golgi apparatus
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
Pfam

PF00069--Pkinase
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0000139--C:Golgi membrane
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0042803--F:protein homodimerization activity
GO:0004672--F:protein kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0032147--P:activation of protein kinase activity
GO:0051683--P:establishment of Golgi localization
GO:0007163--P:establishment or maintenance of cell polarity
GO:0051645--P:Golgi localization
GO:0090168--P:Golgi reassembly
GO:0036481--P:intrinsic apoptotic signaling pathway in response to hydrogen peroxide
GO:0050772--P:positive regulation of axonogenesis
GO:0032874--P:positive regulation of stress-activated MAPK cascade
GO:0046777--P:protein autophosphorylation
GO:0006468--P:protein phosphorylation
GO:0042981--P:regulation of apoptotic process
GO:0007346--P:regulation of mitotic cell cycle
GO:0042542--P:response to hydrogen peroxide
GO:0006979--P:response to oxidative stress
GO:0007165--P:signal transduction
GO:0023014--P:signal transduction by protein phosphorylation
GO:0031098--P:stress-activated protein kinase signaling cascade