dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000115
Uniprot Accession O00501; CLD5_HUMAN; B3KS11; Q53XW2; Q8WUW3;
Genbank Protein ID NP_001124333.1; NP_003268.2;
Genbank Nucleotide ID NM_001130861.1; NM_003277.3;
Protein Name Claudin-5
Protein Synonyms/Alias Transmembrane protein deleted in VCFS;TMDVCF;
Gene Name CLDN5
Gene Synonyms/Alias AWAL;TMVCF;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Plays a major role in tight junction-specific obliteration of the intercellular space.
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
86AARALTVSAVLLAFVPhosphoSitePlus22135298
148NIVVREFYDPSVPVSdbPTM 3.0;PhosphoSitePlus22671590; 16381945; 23193290; 22135298
155YDPSVPVSQKYELGAPhosphoSitePlus22135298
207YSAPRRPTATGDYDKdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated22671590; 16381945; 23193290; 19060867; 22135298; 24702127
209APRRPTATGDYDKKNPhosphoPep 2.0;PhosphoSitePlus19060867; 22135298
212RPTATGDYDKKNYV-dbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 21253578; 18988627; 19060867;
217GDYDKKNYV------dbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus18083107; 16381945; 23193290; 21253578; 18988627; 19060867;
Sequence
(Fasta)		MGSAALEILG LVLCLVGWGG LILACGLPMW QVTAFLDHNI VTAQTTWKGL WMSCVVQSTG 60
HMQCKVYDSV LALSTEVQAA RALTVSAVLL AFVALFVTLA GAQCTTCVAP GPAKARVALT 120
GGVLYLFCGL LALVPLCWFA NIVVREFYDP SVPVSQKYEL GAALYIGWAA TALLMVGGCL 180
LCCGAWVCTG RPDLSFPVKY SAPRRPTATG DYDKKNYV 219
Keyword

KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0796--Tight junction
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR006187--Claudin
IPR003551--Claudin5
IPR017974--Claudin_CS
IPR004031--PMP22/EMP/MP20/Claudin
PROSITE

PS01346--CLAUDIN
Pfam

PF00822--PMP22_Claudin
Gene Ontology

GO:0016327--C:apicolateral plasma membrane
GO:0005923--C:bicellular tight junction
GO:0005911--C:cell-cell junction
GO:0070062--C:extracellular exosome
GO:0016021--C:integral component of membrane
GO:0042802--F:identical protein binding
GO:0005198--F:structural molecule activity
GO:0016338--P:calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
GO:0007043--P:cell-cell junction assembly
GO:0060325--P:face morphogenesis
GO:0007612--P:learning
GO:0003151--P:outflow tract morphogenesis
GO:0060021--P:palate development
GO:1903142--P:positive regulation of establishment of endothelial barrier
GO:0007179--P:transforming growth factor beta receptor signaling pathway