dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000114
Uniprot Accession O00499; BIN1_HUMAN; O00297; O00545; O43867; O60552; O60553; O60554; O60555; O75514; O75515; O75516; O75517; O75518; Q659B7; Q92944; Q99688;
Genbank Protein ID NP_004296.1; NP_647593.1; NP_647594.1; NP_647595.1; NP_647596.1; NP_647597.1; NP_647598.1; NP_647599.1; NP_647600.1; NP_647601.1; XP_005263704.1;
Genbank Nucleotide ID NM_004305.3; NM_139343.2; NM_139344.2; NM_139345.2; NM_139346.2; NM_139347.2; NM_139348.2; NM_139349.2; NM_139350.2; NM_139351.2; XM_005263647.2;
Protein Name Myc box-dependent-interacting protein 1
Protein Synonyms/Alias Amphiphysin II;Amphiphysin-like protein;Box-dependent myc-interacting protein 1;Bridging integrator 1;
Gene Name BIN1
Gene Synonyms/Alias AMPHL;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
Phosphorylation Sites
 dbPAF PTMs: 18
PositionPeptidesSourceReferences ( PMIDs )
56QNFNKQLTEGTRLQKdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
71DLRTYLASVKAMHEAdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298
79VKAMHEASKKLNECLPhosphoSitePlus22135298
150RGRKLVDYDSARHHYPhosphoSitePlus22135298
296APAKGNKSPSPPDGSdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated15302935; 17081983; 18187866; 18669648; 19413330; 16381945;
298AKGNKSPSPPDGSPAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated15302935; 17081983; 17924679; 18669648; 19413330; 16381945;
303SPSPPDGSPAATPEIdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated15302935; 17081983; 18669648; 19413330; 16381945; 23193290;
307PDGSPAATPEIRVNHdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 19367720; 16381945; 23193290; 17081983; 20068231;
323PEPAGGATPGATLPKdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 16381945; 23193290; 19276368; 20068231; 20886841;
327GGATPGATLPKSPSQdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated18669648; 16381945; 23193290; 20068231; 18988627; 22135298;
331PGATLPKSPSQLRKGdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18669648; 16381945; 23193290; 19276368; 20068231;
333ATLPKSPSQLRKGPPdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated18669648; 16381945; 23193290; 19276368; 20068231; 21406692;
348VPPPPKHTPSKEVKQdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 25627689;
350PPPKHTPSKEVKQEQcurated20068231
365ILSLFEDTFVPEISVPhosphoSitePlus22135298
488AASEAASSSLPAVVVdbPTM 3.0;Phospho.ELM 9.018669648; 16381945; 23193290
489ASEAASSSLPAVVVEdbPTM 3.0;Phospho.ELM 9.018669648; 16381945; 23193290
510NGTVEGGSGAGRLDLPhosphoSitePlus22135298
Sequence
(Fasta)		MAEMGSKGVT AGKIASNVQK KLTRAQEKVL QKLGKADETK DEQFEQCVQN FNKQLTEGTR 60
LQKDLRTYLA SVKAMHEASK KLNECLQEVY EPDWPGRDEA NKIAENNDLL WMDYHQKLVD 120
QALLTMDTYL GQFPDIKSRI AKRGRKLVDY DSARHHYESL QTAKKKDEAK IAKPVSLLEK 180
AAPQWCQGKL QAHLVAQTNL LRNQAEEELI KAQKVFEEMN VDLQEELPSL WNSRVGFYVN 240
TFQSIAGLEE NFHKEMSKLN QNLNDVLVGL EKQHGSNTFT VKAQPSDNAP AKGNKSPSPP 300
DGSPAATPEI RVNHEPEPAG GATPGATLPK SPSQLRKGPP VPPPPKHTPS KEVKQEQILS 360
LFEDTFVPEI SVTTPSQFEA PGPFSEQASL LDLDFDPLPP VTSPVKAPTP SGQSIPWDLW 420
EPTESPAGSL PSGEPSAAEG TFAVSWPSQT AEPGPAQPAE ASEVAGGTQP AAGAQEPGET 480
AASEAASSSL PAVVVETFPA TVNGTVEGGS GAGRLDLPPG FMFKVQAQHD YTATDTDELQ 540
LKAGDVVLVI PFQNPEEQDE GWLMGVKESD WNQHKELEKC RGVFPENFTE RVP 594
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0225--Disease mutation
KW-0254--Endocytosis
KW-0945--Host-virus interaction
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0043--Tumor suppressor
Interpro

IPR027267--AH/BAR-dom
IPR003005--Amphiphysin
IPR003023--Amphiphysin_2
IPR004148--BAR_dom
IPR001452--SH3_domain
PROSITE

PS51021--BAR
PS50002--SH3
Pfam

PF03114--BAR
PF14604--SH3_9
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0030424--C:axon
GO:0043194--C:axon initial segment
GO:0005737--C:cytoplasm
GO:0031674--C:I band
GO:0060987--C:lipid tube
GO:0016020--C:membrane
GO:0033268--C:node of Ranvier
GO:0005634--C:nucleus
GO:0030315--C:T-tubule
GO:0030018--C:Z disc
GO:0042802--F:identical protein binding
GO:0070063--F:RNA polymerase binding
GO:0048156--F:tau protein binding
GO:0008283--P:cell proliferation
GO:0006897--P:endocytosis
GO:0060988--P:lipid tube assembly
GO:0042692--P:muscle cell differentiation
GO:0043065--P:positive regulation of apoptotic process
GO:0048711--P:positive regulation of astrocyte differentiation
GO:0071156--P:regulation of cell cycle arrest
GO:0030100--P:regulation of endocytosis
GO:0045664--P:regulation of neuron differentiation
GO:0016032--P:viral process