dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000113
Uniprot Accession O00488; ZN593_HUMAN; B2R4S0; Q5T2H7;
Genbank Protein ID NP_056955.2;
Genbank Nucleotide ID NM_015871.4;
Protein Name Zinc finger protein 593
Protein Synonyms/Alias Zinc finger protein T86;
Gene Name ZNF593
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins.
Phosphorylation Sites
 dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
98QLSVEPYSQEEAERAdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 23663014
132TEVPEMDTST-----dbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated18669648; 16381945; 23193290; 18452278; 18988627; 19060867;
133EVPEMDTST------dbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated17081983; 18669648; 20068231; 16381945; 23193290; 18988627;
134VPEMDTST-------dbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated19276368; 19664995; 16381945; 23193290; 18669648; 20068231;
Sequence
(Fasta)		MGRSRRTGAH RAHSLARQMK AKRRRPDLDE IHRELRPQGS ARPQPDPNAE FDPDLPGGGL 60
HRCLACARYF IDSTNLKTHF RSKDHKKRLK QLSVEPYSQE EAERAAGMGS YVPPRRLAVP 120
TEVSTEVPEM DTST 135
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
IPR022755--Znf_C2H2_jaz
PROSITE

PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF12171--zf-C2H2_jaz
Gene Ontology

GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0003714--F:transcription corepressor activity
GO:0098779--P:mitophagy in response to mitochondrial depolarization
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated