Tag |
Content |
dbPAF ID |
dbPAF-0000112 |
Uniprot Accession |
O00487; PSDE_HUMAN; B3KNW2; O00176; |
Genbank Protein ID |
NP_005796.1; |
Genbank Nucleotide ID |
NM_005805.5; |
Protein Name |
26S proteasome non-ATPase regulatory subunit 14 |
Protein Synonyms/Alias |
26S proteasome regulatory subunit RPN11;26S proteasome-associated PAD1 homolog 1; |
Gene Name |
PSMD14 |
Gene Synonyms/Alias |
POH1; |
Organism |
Homo sapiens(Human) |
NCBI Taxa ID |
9606 |
Functional Description (View all) |
Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.Functional Description
Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.
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Phosphorylation Sites
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dbPAF PTMs: 8 |
Sequence (Fasta) | MDRLLRLGGG MPGLGQGPPT DAPAVDTAEQ VYISSLALLK MLKHGRAGVP MEVMGLMLGE 60 FVDDYTVRVI DVFAMPQSGT GVSVEAVDPV FQAKMLDMLK QTGRPEMVVG WYHSHPGFGC 120 WLSGVDINTQ QSFEALSERA VAVVVDPIQS VKGKVVIDAF RLINANMMVL GHEPRQTTSN 180 LGHLNKPSIQ ALIHGLNRHY YSITINYRKN ELEQKMLLNL HKKSWMEGLT LQDYSEHCKH 240 NESVVKEMLE LAKNYNKAVE EEDKMTPEQL AIKNVGKQDP KRHLEEHVDV LMTSNIVQCL 300 AAMLDTVVFK
311Fasta Sequence
>O00487|PSMD14|Homo sapiens(Human) MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
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Keyword |
KW-0181--Complete proteome KW-0903--Direct protein sequencing KW-0227--DNA damage KW-0234--DNA repair KW-0378--Hydrolase KW-0479--Metal-binding KW-0482--Metalloprotease KW-0597--Phosphoprotein KW-0645--Protease KW-0647--Proteasome KW-1185--Reference proteome KW-0833--Ubl conjugation pathway KW-0862--Zinc
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Interpro |
IPR000555--JAMM/MPN+_dom IPR024969--Rpn11/EIF3F_C
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PROSITE |
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Pfam |
PF01398--JAB PF13012--MitMem_reg
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Gene Ontology |
GO:0005829--C:cytosol GO:0031597--C:cytosolic proteasome complex GO:0070062--C:extracellular exosome GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0022624--C:proteasome accessory complex GO:0000502--C:proteasome complex GO:0008541--C:proteasome regulatory particle, lid subcomplex GO:0061133--F:endopeptidase activator activity GO:0046872--F:metal ion binding GO:0008237--F:metallopeptidase activity GO:0070628--F:proteasome binding GO:0000186--P:activation of MAPKK activity GO:0031145--P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0042590--P:antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0002479--P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002474--P:antigen processing and presentation of peptide antigen via MHC class I GO:0006915--P:apoptotic process GO:0007411--P:axon guidance GO:0034641--P:cellular nitrogen compound metabolic process GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0000724--P:double-strand break repair via homologous recombination GO:0006303--P:double-strand break repair via nonhomologous end joining GO:0007173--P:epidermal growth factor receptor signaling pathway GO:0038095--P:Fc-epsilon receptor signaling pathway GO:0008543--P:fibroblast growth factor receptor signaling pathway GO:0000082--P:G1/S transition of mitotic cell cycle GO:0010467--P:gene expression GO:0045087--P:innate immune response GO:0008286--P:insulin receptor signaling pathway GO:0000165--P:MAPK cascade GO:0000278--P:mitotic cell cycle GO:0043066--P:negative regulation of apoptotic process GO:0090090--P:negative regulation of canonical Wnt signaling pathway GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0048011--P:neurotrophin TRK receptor signaling pathway GO:0038061--P:NIK/NF-kappaB signaling GO:0006595--P:polyamine metabolic process GO:0090263--P:positive regulation of canonical Wnt signaling pathway GO:0010950--P:positive regulation of endopeptidase activity GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition GO:0012501--P:programmed cell death GO:0070536--P:protein K63-linked deubiquitination GO:0000209--P:protein polyubiquitination GO:0007265--P:Ras protein signal transduction GO:0042981--P:regulation of apoptotic process GO:0006521--P:regulation of cellular amino acid metabolic process GO:0043488--P:regulation of mRNA stability GO:0061136--P:regulation of proteasomal protein catabolic process GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0045471--P:response to ethanol GO:0007264--P:small GTPase mediated signal transduction GO:0044281--P:small molecule metabolic process GO:0002223--P:stimulatory C-type lectin receptor signaling pathway GO:0050852--P:T cell receptor signaling pathway GO:0033209--P:tumor necrosis factor-mediated signaling pathway GO:0006511--P:ubiquitin-dependent protein catabolic process GO:0048010--P:vascular endothelial growth factor receptor signaling pathway GO:0016032--P:viral process
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