dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000111
Uniprot Accession O00483; NDUA4_HUMAN; A4D109; Q6FHN5;
Genbank Protein ID NP_002480.1;
Genbank Nucleotide ID NM_002489.3;
Protein Name Cytochrome c oxidase subunit NDUFA4
Protein Synonyms/Alias Complex I-MLRQ;CI-MLRQ;NADH-ubiquinone oxidoreductase MLRQ subunit;
Gene Name NDUFA4
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Cytochrome c oxidase (COX, complex IV) is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. Required for complex IV maintenance.
Phosphorylation Sites
 dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
62KLGPNDQYKFYSVNVPhosphoSitePlus22135298
65PNDQYKFYSVNVDYSdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 22817900; 24260401
66NDQYKFYSVNVDYSKPhosphoSitePlus;curated22135298; 23917254
71FYSVNVDYSKLKKERPhosphoSitePlus22135298
72YSVNVDYSKLKKERPcurated22817900
Sequence
(Fasta)		MLRQIIGQAK KHPSLIPLFV FIGTGATGAT LYLLRLALFN PDVCWDRNNP EPWNKLGPND 60
QYKFYSVNVD YSKLKKERPD F 82
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0249--Electron transport
KW-0431--Leigh syndrome
KW-0472--Membrane
KW-0496--Mitochondrion
KW-0999--Mitochondrion inner membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0679--Respiratory chain
KW-0813--Transport
Interpro

IPR010530--B12D
PROSITE
Pfam

PF06522--B12D
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005743--C:mitochondrial inner membrane
GO:0005747--C:mitochondrial respiratory chain complex I
GO:0005751--C:mitochondrial respiratory chain complex IV
GO:0005739--C:mitochondrion
GO:0008137--F:NADH dehydrogenase (ubiquinone) activity
GO:0032403--F:protein complex binding
GO:0044237--P:cellular metabolic process
GO:1902600--P:hydrogen ion transmembrane transport
GO:0006120--P:mitochondrial electron transport, NADH to ubiquinone
GO:0022904--P:respiratory electron transport chain
GO:0044281--P:small molecule metabolic process