dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000109
Uniprot Accession O00481; BT3A1_HUMAN; A2A278; A8K2C8; B4DIQ1; B4DRM2; E9PGB4; E9PHG8; Q0P515; Q147X5; Q53F15; Q99420; Q9HCY1;
Genbank Protein ID NP_001138480.1; NP_001138481.1; NP_008979.3; NP_919423.1; XP_005248891.1; XP_011512574.1;
Genbank Nucleotide ID NM_001145008.1; NM_001145009.1; NM_007048.5; NM_194441.2; XM_005248834.2; XM_011514272.1;
Protein Name Butyrophilin subfamily 3 member A1
Protein Synonyms/Alias
Gene Name BTN3A1
Gene Synonyms/Alias BTF5;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
316LEELRWRSIQYASRGPhosphoSitePlus22135298
441GLTDGNKYRTLTEPRPhosphoSitePlus22135298
Sequence
(Fasta)		MKMASFLAFL LLNFRVCLLL LQLLMPHSAQ FSVLGPSGPI LAMVGEDADL PCHLFPTMSA 60
ETMELKWVSS SLRQVVNVYA DGKEVEDRQS APYRGRTSIL RDGITAGKAA LRIHNVTASD 120
SGKYLCYFQD GDFYEKALVE LKVAALGSDL HVDVKGYKDG GIHLECRSTG WYPQPQIQWS 180
NNKGENIPTV EAPVVADGVG LYAVAASVIM RGSSGEGVSC TIRSSLLGLE KTASISIADP 240
FFRSAQRWIA ALAGTLPVLL LLLGGAGYFL WQQQEEKKTQ FRKKKREQEL REMAWSTMKQ 300
EQSTRVKLLE ELRWRSIQYA SRGERHSAYN EWKKALFKPA DVILDPKTAN PILLVSEDQR 360
SVQRAKEPQD LPDNPERFNW HYCVLGCESF ISGRHYWEVE VGDRKEWHIG VCSKNVQRKG 420
WVKMTPENGF WTMGLTDGNK YRTLTEPRTN LKLPKPPKKV GVFLDYETGD ISFYNAVDGS 480
HIHTFLDVSF SEALYPVFRI LTLEPTALTI CPA 514
Keyword

KW-0002--3D-structure
KW-1064--Adaptive immunity
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0391--Immunity
KW-0393--Immunoglobulin domain
KW-0472--Membrane
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR001870--B30
2/SPRY--
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR007110--Ig-like_dom
IPR013783--Ig-like_fold
IPR003599--Ig_sub
IPR013106--Ig_V-set
IPR006574--PRY
IPR003877--SPRY_dom
PROSITE

PS50188--B302_SPRY
PS50835--IG_LIKE
Pfam

PF13765--PRY
PF00622--SPRY
PF07686--V-set
Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0050798--P:activated T cell proliferation
GO:0002250--P:adaptive immune response
GO:0050663--P:cytokine secretion
GO:0072643--P:interferon-gamma secretion
GO:0050852--P:T cell receptor signaling pathway