| Tag |
Content |
| dbPAF ID |
dbPAF-0000106 |
| Uniprot Accession |
O00476; NPT4_HUMAN; B7WNJ5; B7Z511; Q8WWC7; Q9H533;
|
| Genbank Protein ID |
NP_001091956.1; NP_006623.2;
|
| Genbank Nucleotide ID |
NM_001098486.1; NM_006632.3;
|
| Protein Name |
Sodium-dependent phosphate transport protein 4 |
| Protein Synonyms/Alias |
Na(+)/PI cotransporter 4;Sodium/phosphate cotransporter 4;Solute carrier family 17 member 3; |
| Gene Name |
SLC17A3 |
| Gene Synonyms/Alias |
NPT4; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport.Functional Description
Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 355 | SSFLMGASRGFSSIA | PhosphoSitePlus | 22135298 |
|
Sequence
(Fasta) | MATKTELSPT ARESKNAQDM QVDETLIPRK VPSLCSARYG IALVLHFCNF TTIAQNVIMN 60
ITMVAMVNST SPQSQLNDSS EVLPVDSFGG LSKAPKSLPA KSSILGGQFA IWEKWGPPQE 120
RSRLCSIALS GMLLGCFTAI LIGGFISETL GWPFVFYIFG GVGCVCCLLW FVVIYDDPVS 180
YPWISTSEKE YIISSLKQQV GSSKQPLPIK AMLRSLPIWS ICLGCFSHQW LVSTMVVYIP 240
TYISSVYHVN IRDNGLLSAL PFIVAWVIGM VGGYLADFLL TKKFRLITVR KIATILGSLP 300
SSALIVSLPY LNSGYITATA LLTLSCGLST LCQSGIYINV LDIAPRYSSF LMGASRGFSS 360
IAPVIVPTVS GFLLSQDPEF GWRNVFFLLF AVNLLGLLFY LIFGEADVQE WAKERKLTRL 420
421Fasta Sequence
>O00476|SLC17A3|Homo sapiens(Human)
MATKTELSPTARESKNAQDMQVDETLIPRKVPSLCSARYGIALVLHFCNFTTIAQNVIMNITMVAMVNSTSPQSQLNDSSEVLPVDSFGGLSKAPKSLPAKSSILGGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIYDDPVSYPWISTSEKEYIISSLKQQVGSSKQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGYLADFLLTKKFRLITVRKIATILGSLPSSALIVSLPYLNSGYITATALLTLSCGLSTLCQSGIYINVLDIAPRYSSFLMGASRGFSSIAPVIVPTVSGFLLSQDPEFGWRNVFFLLFAVNLLGLLFYLIFGEADVQEWAKERKLTRL
|
| Keyword |
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0406--Ion transport
KW-0472--Membrane
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0915--Sodium
KW-0739--Sodium transport
KW-0769--Symport
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
|
| Interpro |
IPR011701--MFS
IPR020846--MFS_dom
IPR017373--Na-dep_P-transpt_4_prd
|
| PROSITE |
PS50850--MFS
|
| Pfam |
PF07690--MFS_1
|
| Gene Ontology |
GO:0016324--C:apical plasma membrane
GO:0031526--C:brush border membrane
GO:0005737--C:cytoplasm
GO:0005789--C:endoplasmic reticulum membrane
GO:0005887--C:integral component of plasma membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0015238--F:drug transmembrane transporter activity
GO:0015562--F:efflux transmembrane transporter activity
GO:0008514--F:organic anion transmembrane transporter activity
GO:0015321--F:sodium-dependent phosphate transmembrane transporter activity
GO:0005436--F:sodium:phosphate symporter activity
GO:0019534--F:toxin transporter activity
GO:0015143--F:urate transmembrane transporter activity
GO:0008308--F:voltage-gated anion channel activity
GO:0006855--P:drug transmembrane transport
GO:0015893--P:drug transport
GO:0015760--P:glucose-6-phosphate transport
GO:0034220--P:ion transmembrane transport
GO:1903825--P:organic acid transmembrane transport
GO:0015711--P:organic anion transport
GO:0035435--P:phosphate ion transmembrane transport
GO:0006817--P:phosphate ion transport
GO:1903959--P:regulation of anion transmembrane transport
GO:0035725--P:sodium ion transmembrane transport
GO:0006814--P:sodium ion transport
GO:0044341--P:sodium-dependent phosphate transport
GO:1901998--P:toxin transport
GO:0055085--P:transmembrane transport
GO:0046415--P:urate metabolic process
GO:0015747--P:urate transport
|
