dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000105
Uniprot Accession O00472; ELL2_HUMAN; B4DNK7;
Genbank Protein ID NP_036213.2;
Genbank Nucleotide ID NM_012081.5;
Protein Name RNA polymerase II elongation factor ELL2
Protein Synonyms/Alias
Gene Name ELL2
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.
Phosphorylation Sites
dbPAF PTMs: 31 (View all)
PositionPeptidesSourceReferences ( PMIDs )
6--MAAGGTGGLREEQPHOSIDA21081558
37LHVKLTETAIRALETPhosphoSitePlus;curated22135298; 23186163
145MTQAEEESRNRSTKVPhosphoSitePlus22135298
258LNSKDLSYTLKDYVFPhosphoSitePlus22135298
282YSEIDRRSLESVLSRPhosphoSitePlus22135298
301SQNAAGTSRSESPVCcurated25627689
303NAAGTSRSESPVCSSPhosphoSitePlus;curated22135298; 25627689
305AGTSRSESPVCSSRDdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 25627689;
309RSESPVCSSRDAVSSPhosphoSitePlus;curated22135298; 25627689
310SESPVCSSRDAVSSPdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated18452278; 16381945; 23193290; 18988627; 22135298; 25627689
315CSSRDAVSSPQKRLLdbPTM 3.0;HPRD 9;curated18691976; 16381945; 23193290; 18988627; 25627689; 22817900
316SSRDAVSSPQKRLLDdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 25627689;
380PTPPPLPSTYLPISHcurated20873877
381TPPPLPSTYLPISHPcurated20873877
382PPPLPSTYLPISHPPcurated20873877
386PSTYLPISHPPQIVNcurated20873877
394HPPQIVNSNSNSPSTcurated20873877
396PQIVNSNSNSPSTPEcurated20873877
398IVNSNSNSPSTPEGRcurated20873877
400NSNSNSPSTPEGRGTcurated20873877
Sequence
(Fasta)
MAAGGTGGLR EEQRYGLSCG RLGQDNITVL HVKLTETAIR ALETYQSHKN LIPFRPSIQF 60
QGLHGLVKIP KNDPLNEVHN FNFYLSNVGK DNPQGSFDCI QQTFSSSGAS QLNCLGFIQD 120
KITVCATNDS YQMTRERMTQ AEEESRNRST KVIKPGGPYV GKRVQIRKAP QAVSDTVPER 180
KRSTPMNPAN TIRKTHSSST ISQRPYRDRV IHLLALKAYK KPELLARLQK DGVNQKDKNS 240
LGAILQQVAN LNSKDLSYTL KDYVFKELQR DWPGYSEIDR RSLESVLSRK LNPSQNAAGT 300
SRSESPVCSS RDAVSSPQKR LLDSEFIDPL MNKKARISHL TNRVPPTLNG HLNPTSEKSA 360
AGLPLPPAAA AIPTPPPLPS TYLPISHPPQ IVNSNSNSPS TPEGRGTQDL PVDSFSQNDS 420
IYEDQQDKYT SRTSLETLPP GSVLLKCPKP MEENHSMSHK KSKKKSKKHK EKDQIKKHDI 480
ETIEEKEEDL KREEEIAKLN NSSPNSSGGV KEDCTASMEP SAIELPDYLI KYIAIVSYEQ 540
RQNYKDDFNA EYDEYRALHA RMETVARRFI KLDAQRKRLS PGSKEYQNVH EEVLQEYQKI 600
KQSSPNYHEE KYRCEYLHNK LAHIKRLIGE FDQQQAESWS 641
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation

Interpro

IPR031176--ELL/occludin
IPR031179--ELL2
IPR019464--ELL_N
IPR010844--Occludin_ELL
IPR011991--WHTH_DNA-bd_dom

PROSITE
Pfam

PF10390--ELL
PF07303--Occludin_ELL

Gene Ontology

GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0008023--C:transcription elongation factor complex
GO:0006355--P:regulation of transcription, DNA-templated
GO:0042795--P:snRNA transcription from RNA polymerase II promoter
GO:0006368--P:transcription elongation from RNA polymerase II promoter