| Tag |
Content |
| dbPAF ID |
dbPAF-0000103 |
| Uniprot Accession |
O00470; MEIS1_HUMAN; A8MV50;
|
| Genbank Protein ID |
NP_002389.1;
|
| Genbank Nucleotide ID |
NM_002398.2;
|
| Protein Name |
Homeobox protein Meis1 |
| Protein Synonyms/Alias |
|
| Gene Name |
MEIS1 |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.Functional Description
Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MAQRYDDLPH YGGMDGVGIP STMYGDPHAA RSMQPVHHLN HGPPLHSHQY PHTAHTNAMA 60
PSMGSSVNDA LKRDKDAIYG HPLFPLLALI FEKCELATCT PREPGVAGGD VCSSESFNED 120
IAVFAKQIRA EKPLFSSNPE LDNLMIQAIQ VLRFHLLELE KVHELCDNFC HRYISCLKGK 180
MPIDLVIDDR EGGSKSDSED ITRSANLTDQ PSWNRDHDDT ASTRSGGTPG PSSGGHTSHS 240
GDNSSEQGDG LDNSVASPST GDDDDPDKDK KRHKKRGIFP KVATNIMRAW LFQHLTHPYP 300
SEEQKKQLAQ DTGLTILQVN NWFINARRRI VQPMIDQSNR AVSQGTPYNP DGQPMGGFVM 360
DGQQHMGIRA PGPMSGMGMN MGMEGQWHYM
391Fasta Sequence
>O00470|MEIS1|Homo sapiens(Human)
MAQRYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPPLHSHQYPHTAHTNAMAPSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPREPGVAGGDVCSSESFNEDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDDREGGSKSDSEDITRSANLTDQPSWNRDHDDTASTRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGPMSGMGMNMGMEGQWHYM
|
| Keyword |
KW-0010--Activator
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0371--Homeobox
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
|
| Interpro |
IPR001356--Homeobox_dom
IPR008422--Homeobox_KN_domain
IPR009057--Homeodomain-like
IPR032453--PKNOX/Meis_N
|
| PROSITE |
PS50071--HOMEOBOX_2
|
| Pfam |
PF05920--Homeobox_KN
PF16493--Meis_PKNOX_N
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0005667--C:transcription factor complex
GO:0003682--F:chromatin binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003705--F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001525--P:angiogenesis
GO:0060216--P:definitive hemopoiesis
GO:0002089--P:lens morphogenesis in camera-type eye
GO:0007626--P:locomotory behavior
GO:0035855--P:megakaryocyte development
GO:0045638--P:negative regulation of myeloid cell differentiation
GO:0045665--P:negative regulation of neuron differentiation
|
