dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000102
Uniprot Accession O00469; PLOD2_HUMAN; B3KWS3; Q59ED2; Q8N170;
Genbank Protein ID NP_000926.2; NP_891988.1;
Genbank Nucleotide ID NM_000935.2; NM_182943.2;
Protein Name Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Protein Synonyms/Alias Lysyl hydroxylase 2;LH2;
Gene Name PLOD2
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
61RFMQSAKYFNYTVKVcurated23898821
64QSAKYFNYTVKVLGQcurated23898821
65SAKYFNYTVKVLGQGcurated23898821
163VVHIGKRYLNSGGFIPhosphoSitePlus22135298
172NSGGFIGYAPYVNRIPhosphoSitePlus22135298
320RFLDILLTLDYPKEAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt18088087; 16381945; 23193290; 18988627; 19060867; 22135298;
323DILLTLDYPKEALKLdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt18088087; 16381945; 23193290; 18988627; 19060867; 22135298;
437GALSPDGYYARSEDYdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
438ALSPDGYYARSEDYVcurated20068231
590MEHYGKWSGGKHHDSPhosphoSitePlus22135298
600KHHDSRISGGYENVPPhosphoSitePlus;curated22135298; 25627689
608GGYENVPTDDIHMKQPhosphoSitePlus22135298
Sequence
(Fasta)		MGGCTVKPQL LLLALVLHPW NPCLGADSEK PSSIPTDKLL VITVATKESD GFHRFMQSAK 60
YFNYTVKVLG QGEEWRGGDG INSIGGGQKV RLMKEVMEHY ADQDDLVVMF TECFDVIFAG 120
GPEEVLKKFQ KANHKVVFAA DGILWPDKRL ADKYPVVHIG KRYLNSGGFI GYAPYVNRIV 180
QQWNLQDNDD DQLFYTKVYI DPLKREAINI TLDHKCKIFQ TLNGAVDEVV LKFENGKARA 240
KNTFYETLPV AINGNGPTKI LLNYFGNYVP NSWTQDNGCT LCEFDTVDLS AVDVHPNVSI 300
GVFIEQPTPF LPRFLDILLT LDYPKEALKL FIHNKEVYHE KDIKVFFDKA KHEIKTIKIV 360
GPEENLSQAE ARNMGMDFCR QDEKCDYYFS VDADVVLTNP RTLKILIEQN RKIIAPLVTR 420
HGKLWSNFWG ALSPDGYYAR SEDYVDIVQG NRVGVWNVPY MANVYLIKGK TLRSEMNERN 480
YFVRDKLDPD MALCRNAREM GVFMYISNRH EFGRLLSTAN YNTSHYNNDL WQIFENPVDW 540
KEKYINRDYS KIFTENIVEQ PCPDVFWFPI FSEKACDELV EEMEHYGKWS GGKHHDSRIS 600
GGYENVPTDD IHMKQVDLEN VWLHFIREFI APVTLKVFAG YYTKGFALLN FVVKYSPERQ 660
RSLRPHHDAS TFTINIALNN VGEDFQGGGC KFLRYNCSIE SPRKGWSFMH PGRLTHLHEG 720
LPVKNGTRYI AVSFIDP 738
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0225--Disease mutation
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0408--Iron
KW-0472--Membrane
KW-0479--Metal-binding
KW-1065--Osteogenesis imperfecta
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0732--Signal
KW-0847--Vitamin C
Interpro

IPR029044--Nucleotide-diphossugar_trans
IPR005123--Oxoglu/Fe-dep_dioxygenase
IPR006620--Pro_4_hyd_alph
IPR001006--Procol_lys_dOase
PROSITE

PS51471--FE2OG_OXY
PS01325--LYS_HYDROXYLASE
Pfam

PF03171--2OG-FeII_Oxy
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0070062--C:extracellular exosome
GO:0030867--C:rough endoplasmic reticulum membrane
GO:0005506--F:iron ion binding
GO:0031418--F:L-ascorbic acid binding
GO:0008475--F:procollagen-lysine 5-dioxygenase activity
GO:0006464--P:cellular protein modification process
GO:0032870--P:cellular response to hormone stimulus
GO:0030198--P:extracellular matrix organization
GO:0098779--P:mitophagy in response to mitochondrial depolarization
GO:0001666--P:response to hypoxia