dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000099
Uniprot Accession O00462; MANBA_HUMAN; Q96BC3; Q9NYX9;
Genbank Protein ID NP_005899.3;
Genbank Nucleotide ID NM_005908.3;
Protein Name Beta-mannosidase
Protein Synonyms/Alias Lysosomal beta A mannosidase;Mannanase;Mannase;
Gene Name MANBA
Gene Synonyms/Alias MANB1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
161QSKAHTRYQVPPDCPPhosphoSitePlus22135298
325SAKVYFRTVELIEEPPhosphoSitePlus22135298
477SFTDRPIYIKDYVTLdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
481RPIYIKDYVTLYVKNdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
485IKDYVTLYVKNIRELdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
597GGNKQMLYQAGLHFKPhosphoSitePlus22135298
847SDNGFLMTEKTRTILPhosphoSitePlus22135298
Sequence
(Fasta)		MRLHLLLLLA LCGAGTTAAE LSYSLRGNWS ICNGNGSLEL PGAVPGCVHS ALFQQGLIQD 60
SYYRFNDLNY RWVSLDNWTY SKEFKIPFEI SKWQKVNLIL EGVDTVSKIL FNEVTIGETD 120
NMFNRYSFDI TNVVRDVNSI ELRFQSAVLY AAQQSKAHTR YQVPPDCPPL VQKGECHVNF 180
VRKEQCSFSW DWGPSFPTQG IWKDVRIEAY NICHLNYFTF SPIYDKSAQE WNLEIESTFD 240
VVSSKPVGGQ VIVAIPKLQT QQTYSIELQP GKRIVELFVN ISKNITVETW WPHGHGNQTG 300
YNMTVLFELD GGLNIEKSAK VYFRTVELIE EPIKGSPGLS FYFKINGFPI FLKGSNWIPA 360
DSFQDRVTSE LLRLLLQSVV DANMNTLRVW GGGIYEQDEF YELCDELGIM VWQDFMFACA 420
LYPTDQGFLD SVTAEVAYQI KRLKSHPSII IWSGNNENEE ALMMNWYHIS FTDRPIYIKD 480
YVTLYVKNIR ELVLAGDKSR PFITSSPTNG AETVAEAWVS QNPNSNYFGD VHFYDYISDC 540
WNWKVFPKAR FASEYGYQSW PSFSTLEKVS STEDWSFNSK FSLHRQHHEG GNKQMLYQAG 600
LHFKLPQSTD PLRTFKDTIY LTQVMQAQCV KTETEFYRRS RSEIVDQQGH TMGALYWQLN 660
DIWQAPSWAS LEYGGKWKML HYFAQNFFAP LLPVGFENEN TFYIYGVSDL HSDYSMTLSV 720
RVHTWSSLEP VCSRVTERFV MKGGEAVCLY EEPVSELLRR CGNCTRESCV VSFYLSADHE 780
LLSPTNYHFL SSPKEAVGLC KAQITAIISQ QGDIFVFDLE TSAVAPFVWL DVGSIPGRFS 840
DNGFLMTEKT RTILFYPWEP TSKNELEQSF HVTSLTDIY
Keyword

KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0326--Glycosidase
KW-0378--Hydrolase
KW-0458--Lysosome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0732--Signal
Interpro

IPR008979--Galactose-bd-like
IPR013812--Glyco_hydro_2/20_Ig-like
IPR006103--Glyco_hydro_2_cat
IPR006102--Glyco_hydro_2_Ig-like
IPR006104--Glyco_hydro_2_N
IPR013781--Glyco_hydro_catalytic_dom
IPR017853--Glycoside_hydrolase_SF
PROSITE
Pfam

PF02836--Glyco_hydro_2_C
PF02837--Glyco_hydro_2_N
Gene Ontology

GO:0005764--C:lysosome
GO:0004567--F:beta-mannosidase activity
GO:0005537--F:mannose binding
GO:0006464--P:cellular protein modification process
GO:0006516--P:glycoprotein catabolic process
GO:0046355--P:mannan catabolic process