dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000094
Uniprot Accession O00451; GFRA2_HUMAN; E9PD47; O15316; O15328; Q58J92; Q6GTR9; Q7Z5C2;
Genbank Protein ID NP_001158510.1; NP_001158511.1; NP_001486.4; XP_006716390.1; XP_011542786.1; XP_011542787.1;
Genbank Nucleotide ID NM_001165038.1; NM_001165039.1; NM_001495.4; XM_006716327.2; XM_011544484.1; XM_011544485.1;
Protein Name GDNF family receptor alpha-2
Protein Synonyms/Alias
Gene Name GFRA2
Gene Synonyms/Alias GDNFRB;RETL2;TRNR2;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.
Phosphorylation Sites
 dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
179DNCKKLRSSYISICNPhosphoSitePlus22135298
441NKVIKPNSGPSRARPPhosphoSitePlus22135298
444IKPNSGPSRARPSAAPhosphoSitePlus22135298
Sequence
(Fasta)		MILANVFCLF FFLDETLRSL ASPSSLQGPE LHGWRPPVDC VRANELCAAE SNCSSRYRTL 60
RQCLAGRDRN TMLANKECQA ALEVLQESPL YDCRCKRGMK KELQCLQIYW SIHLGLTEGE 120
EFYEASPYEP VTSRLSDIFR LASIFSGTGA DPVVSAKSNH CLDAAKACNL NDNCKKLRSS 180
YISICNREIS PTERCNRRKC HKALRQFFDR VPSEYTYRML FCSCQDQACA ERRRQTILPS 240
CSYEDKEKPN CLDLRGVCRT DHLCRSRLAD FHANCRASYQ TVTSCPADNY QACLGSYAGM 300
IGFDMTPNYV DSSPTGIVVS PWCSCRGSGN MEEECEKFLR DFTENPCLRN AIQAFGNGTD 360
VNVSPKGPSF QATQAPRVEK TPSLPDDLSD STSLGTSVIT TCTSVQEQGL KANNSKELSM 420
CFTELTTNII PGSNKVIKPN SGPSRARPSA ALTVLSVLML KLAL 465
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0336--GPI-anchor
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0732--Signal
Interpro

IPR016017--GDNF/GAS1
IPR003438--GDNF_rcpt
IPR003504--GDNF_rcpt_a2
IPR017372--Glial_neurotroph_fac_rcpt_a1/2
PROSITE
Pfam

PF02351--GDNF
Gene Ontology

GO:0031225--C:anchored component of membrane
GO:0019898--C:extrinsic component of membrane
GO:0005886--C:plasma membrane
GO:0016167--F:glial cell-derived neurotrophic factor receptor activity
GO:0031953--P:negative regulation of protein autophosphorylation
GO:0007399--P:nervous system development
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway