dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000093
Uniprot Accession O00445; SYT5_HUMAN; B3KWJ8; B7Z300; Q86X72;
Genbank Protein ID NP_001284703.1; NP_003171.2; XP_006723402.1;
Genbank Nucleotide ID NM_001297774.1; NM_003180.2; XM_006723339.2;
Protein Name Synaptotagmin-5
Protein Synonyms/Alias Synaptotagmin V;SytV;
Gene Name SYT5
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
15PGPPSPDTPPDSSRIPhosphoSitePlus22135298
19SPDTPPDSSRISHGPPhosphoSitePlus22135298
20PDTPPDSSRISHGPVPhosphoSitePlus22135298
59RKSCRRRTGKKSQAQPhosphoSitePlus22135298
81VKGLGQSYIDKVQPEPhosphoSitePlus22135298
196RVLVMAVYDFDRFSRPhosphoSitePlus22135298
202VYDFDRFSRNDAIGEPhosphoSitePlus22135298
278VGGLSDPYVKVHLLQPhosphoPep 2.0;PhosphoSitePlus;curated19060867; 22135298; 22817900
Sequence
(Fasta)		MFPEPPTPGP PSPDTPPDSS RISHGPVPPW ALATIVLVSG LLIFSCCFCL YRKSCRRRTG 60
KKSQAQAQVH LQEVKGLGQS YIDKVQPEVE ELEPAPSGPG QQVADKHELG RLQYSLDYDF 120
QSGQLLVGIL QAMGLAALDL GGSSDPYVRV YLLPDKRRRY ETKVHRQTLN PHFGETFAFK 180
VPYVELGGRV LVMAVYDFDR FSRNDAIGEV RVPMSSVDLG RPVQAWRELQ AAPREEQEKL 240
GDICFSLRYV PTAGKLTVIV LEAKNLKKMD VGGLSDPYVK VHLLQGGKKV RKKKTTIKKN 300
TLNPYYNEAF SFEVPCDQVQ KVQVELTVLD YDKLGKNEAI GRVAVGAAAG GAGLRHWADM 360
LANPRRPIAQ WHSLRPPDRV RLLPAP 387
Keyword

KW-0025--Alternative splicing
KW-0106--Calcium
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0967--Endosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0770--Synapse
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR000008--C2_dom
IPR001565--Synaptotagmin
PROSITE

PS50004--C2
Pfam

PF00168--C2
Gene Ontology

GO:0030054--C:cell junction
GO:0031045--C:dense core granule
GO:0016021--C:integral component of membrane
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0055038--C:recycling endosome membrane
GO:0030672--C:synaptic vesicle membrane
GO:0005509--F:calcium ion binding
GO:0005544--F:calcium-dependent phospholipid binding
GO:0030276--F:clathrin binding
GO:0019905--F:syntaxin binding
GO:0048791--P:calcium ion-dependent exocytosis of neurotransmitter
GO:0006112--P:energy reserve metabolic process
GO:0017158--P:regulation of calcium ion-dependent exocytosis
GO:0050796--P:regulation of insulin secretion
GO:0044281--P:small molecule metabolic process
GO:0007268--P:synaptic transmission
GO:0048488--P:synaptic vesicle endocytosis
GO:0016079--P:synaptic vesicle exocytosis