dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000089
Uniprot Accession O00429; DNM1L_HUMAN; A8K4X9; B4DGC9; B4DSU8; J3KPI2; O14541; O60709; Q59GN9; Q7L6B3; Q8TBT7; Q9BWM1; Q9Y5J2;
Genbank Protein ID NP_001265392.1; NP_001265393.1; NP_001265394.1; NP_001265395.1; NP_005681.2; NP_036192.2; NP_036193.2;
Genbank Nucleotide ID NM_001278463.1; NM_001278464.1; NM_001278465.1; NM_001278466.1; NM_005690.4; NM_012062.4; NM_012063.3;
Protein Name Dynamin-1-like protein
Protein Synonyms/Alias Dnm1p/Vps1p-like protein;DVLP;Dynamin family member proline-rich carboxyl-terminal domain less;Dymple;Dynamin-like protein;Dynamin-like protein 4;Dynamin-like protein IV;HdynIV;Dynamin-related protein 1;
Gene Name DNM1L
Gene Synonyms/Alias DLP1;DRP1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution.
Phosphorylation Sites
 dbPAF PTMs: 25 (View all)
PositionPeptidesSourceReferences ( PMIDs )
40TQSSGKSSVLESLVGPhosphoSitePlus22135298
44GKSSVLESLVGRDLLPhosphoSitePlus22135298
78SQEDKRKTTGEENGVdbPTM 3.0;PhosphoSitePlus;curated19690332; 16381945; 23193290; 22135298; 24260401
79QEDKRKTTGEENGVEdbPTM 3.0;PhosphoSitePlus;curated19690332; 16381945; 23193290; 22135298
126SGNNKGVSPEPIHLKPhosphoSitePlus;curated22135298; 25627689
179RFISNPNSIILAVTAPhosphoSitePlus22135298
193AANTDMATSEALKISdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298
194ANTDMATSEALKISRdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
330GEPVDDKSATLLQLIPhosphoSitePlus22135298
394LNTIDILTAIRNATGPhosphoSitePlus22135298
400LTAIRNATGPRPALFPhosphoSitePlus22135298
412ALFVPEVSFELLVKRPhosphoSitePlus22135298
529RELPSAVSRDKSSKVdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19664995; 22115753; 16381945; 23193290; 18988627; 22135298;
544PSALAPASQEPSPAAPhosphoSitePlus;curated22135298; 25627689; 22199227
548APASQEPSPAASAEAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 16381945; 23193290; 18988627; 19060867; 22135298;
552QEPSPAASAEADGKLPhosphoSitePlus22135298
572RETKNVASGGGGVGDPhosphoSitePlus;curated22135298; 25627689; 22199227
586DGVQEPTTGNWRGMLPhosphoSitePlus22135298
595NWRGMLKTSKAEELLPhosphoSitePlus22135298
607ELLAEEKSKPIPIMPdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;UniProt;curated18669648; 16381945; 23193290; 18988627; 22135298; 26074081
Sequence
(Fasta)		MEALIPVINK LQDVFNTVGA DIIQLPQIVV VGTQSSGKSS VLESLVGRDL LPRGTGIVTR 60
RPLILQLVHV SQEDKRKTTG EENGVEAEEW GKFLHTKNKL YTDFDEIRQE IENETERISG 120
NNKGVSPEPI HLKIFSPNVV NLTLVDLPGM TKVPVGDQPK DIELQIRELI LRFISNPNSI 180
ILAVTAANTD MATSEALKIS REVDPDGRRT LAVITKLDLM DAGTDAMDVL MGRVIPVKLG 240
IIGVVNRSQL DINNKKSVTD SIRDEYAFLQ KKYPSLANRN GTKYLARTLN RLLMHHIRDC 300
LPELKTRINV LAAQYQSLLN SYGEPVDDKS ATLLQLITKF ATEYCNTIEG TAKYIETSEL 360
CGGARICYIF HETFGRTLES VDPLGGLNTI DILTAIRNAT GPRPALFVPE VSFELLVKRQ 420
IKRLEEPSLR CVELVHEEMQ RIIQHCSNYS TQELLRFPKL HDAIVEVVTC LLRKRLPVTN 480
EMVHNLVAIE LAYINTKHPD FADACGLMNN NIEEQRRNRL ARELPSAVSR DKSSKVPSAL 540
APASQEPSPA ASAEADGKLI QDSRRETKNV ASGGGGVGDG VQEPTTGNWR GMLKTSKAEE 600
LLAEEKSKPI PIMPASPQKG HAVNLLDVPV PVARKLSARE QRDCEVIERL IKSYFLIVRK 660
NIQDSVPKAV MHFLVNHVKD TLQSELVGQL YKSSLLDDLL TESEDMAQRR KEAADMLKAL 720
QGASQIIAEI RETHLW 737
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0168--Coated pit
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0225--Disease mutation
KW-0254--Endocytosis
KW-0325--Glycoprotein
KW-0333--Golgi apparatus
KW-0342--GTP-binding
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-1210--Necrosis
KW-0547--Nucleotide-binding
KW-0576--Peroxisome
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0702--S-nitrosylation
KW-0770--Synapse
KW-0832--Ubl conjugation
Interpro

IPR030556--DNM1L
IPR000375--Dynamin_central
IPR001401--Dynamin_GTPase
IPR019762--Dynamin_GTPase_CS
IPR022812--Dynamin_SF
IPR030381--G_DYNAMIN_dom
IPR003130--GED
IPR020850--GED_dom
IPR027417--P-loop_NTPase
PROSITE

PS00410--G_DYNAMIN_1
PS51718--G_DYNAMIN_2
PS51388--GED
Pfam

PF01031--Dynamin_M
PF00350--Dynamin_N
PF02212--GED
Gene Ontology

GO:0005903--C:brush border
GO:0030054--C:cell junction
GO:0005905--C:coated pit
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016020--C:membrane
GO:0005874--C:microtubule
GO:0005741--C:mitochondrial outer membrane
GO:0005739--C:mitochondrion
GO:0048471--C:perinuclear region of cytoplasm
GO:0005777--C:peroxisome
GO:0043234--C:protein complex
GO:0030672--C:synaptic vesicle membrane
GO:0005525--F:GTP binding
GO:0003924--F:GTPase activity
GO:0042802--F:identical protein binding
GO:0008289--F:lipid binding
GO:0042803--F:protein homodimerization activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0006915--P:apoptotic process
GO:0006921--P:cellular component disassembly involved in execution phase of apoptosis
GO:0003374--P:dynamin polymerization involved in mitochondrial fission
GO:0006897--P:endocytosis
GO:0060047--P:heart contraction
GO:0061025--P:membrane fusion
GO:0000266--P:mitochondrial fission
GO:0043653--P:mitochondrial fragmentation involved in apoptotic process
GO:0090149--P:mitochondrial membrane fission
GO:0070584--P:mitochondrion morphogenesis
GO:0070266--P:necroptotic process
GO:0016559--P:peroxisome fission
GO:0043065--P:positive regulation of apoptotic process
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0090141--P:positive regulation of mitochondrial fission
GO:0050714--P:positive regulation of protein secretion
GO:0090200--P:positive regulation of release of cytochrome c from mitochondria
GO:0012501--P:programmed cell death
GO:0051289--P:protein homotetramerization
GO:0070585--P:protein localization to mitochondrion
GO:1903578--P:regulation of ATP metabolic process
GO:0010821--P:regulation of mitochondrion organization
GO:1903146--P:regulation of mitophagy
GO:1900063--P:regulation of peroxisome organization
GO:0032459--P:regulation of protein oligomerization
GO:0001836--P:release of cytochrome c from mitochondria