dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000088
Uniprot Accession O00425; IF2B3_HUMAN; A0A4Z5; Q63HM0; Q6MZZ2; Q86VB1;
Genbank Protein ID NP_006538.2;
Genbank Nucleotide ID NM_006547.2;
Protein Name Insulin-like growth factor 2 mRNA-binding protein 3
Protein Synonyms/Alias
Gene Name IGF2BP3
Gene Synonyms/Alias IMP3;KOC1;VICKZ3;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.
Phosphorylation Sites
 dbPAF PTMs: 21 (View all)
PositionPeptidesSourceReferences ( PMIDs )
10KLYIGNLSENAAPSDcurated20873877
16LSENAAPSDLESIFKcurated20873877
20AAPSDLESIFKDAKIcurated20873877
30KDAKIPVSGPFLVKTdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 22817900
39PFLVKTGYAFVDCPDPhosphoSitePlus22135298
73KPIEVEHSVPKRQRIcurated20873877
179RGLGQRGSSRQGSPGcurated23898821; 22817900; 24961811; 25262027
180GLGQRGSSRQGSPGSPhosphoSitePlus;curated22135298; 23898821; 22817900; 24961811; 25262027
184RGSSRQGSPGSVSKQdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;UniProt;curated20363803; 21406692; 16381945; 23193290; 19651622; 20068231;
187SRQGSPGSVSKQKPCdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated21406692; 16381945; 23193290; 19651622; 18988627; 22135298;
189QGSPGSVSKQKPCDLdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 23090842; 22817900
243NAGAAEKSITILSTPdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 25627689;
249KSITILSTPEGTSAAPhosphoSitePlus;curated22135298; 25627689; 22817900
259GTSAACKSILEIMHKcurated20873877
438LSRFAGASIKIAPAEPhosphoSitePlus;curated22135298; 23911959; 23186163; 24961811
481IKEENFVSPKEEVKLPhosphoSitePlus;curated22135298; 25627689
496EAHIRVPSFAAGRVIPhosphoSitePlus;curated22135298; 20873877
528VVVPRDQTPDENDQVdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 19690332; 16381945; 23193290; 21406692; 18988627;
544VKITGHFYACQVAQRcurated23663014
571QQQKALQSGPPQSRRdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 22817900
Sequence
(Fasta)		MNKLYIGNLS ENAAPSDLES IFKDAKIPVS GPFLVKTGYA FVDCPDESWA LKAIEALSGK 60
IELHGKPIEV EHSVPKRQRI RKLQIRNIPP HLQWEVLDSL LVQYGVVESC EQVNTDSETA 120
VVNVTYSSKD QARQALDKLN GFQLENFTLK VAYIPDEMAA QQNPLQQPRG RRGLGQRGSS 180
RQGSPGSVSK QKPCDLPLRL LVPTQFVGAI IGKEGATIRN ITKQTQSKID VHRKENAGAA 240
EKSITILSTP EGTSAACKSI LEIMHKEAQD IKFTEEIPLK ILAHNNFVGR LIGKEGRNLK 300
KIEQDTDTKI TISPLQELTL YNPERTITVK GNVETCAKAE EEIMKKIRES YENDIASMNL 360
QAHLIPGLNL NALGLFPPTS GMPPPTSGPP SAMTPPYPQF EQSETETVHL FIPALSVGAI 420
IGKQGQHIKQ LSRFAGASIK IAPAEAPDAK VRMVIITGPP EAQFKAQGRI YGKIKEENFV 480
SPKEEVKLEA HIRVPSFAAG RVIGKGGKTV NELQNLSSAE VVVPRDQTPD ENDQVVVKIT 540
GHFYACQVAQ RKIQEILTQV KQHQQQKALQ SGPPQSRRK
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0509--mRNA transport
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0810--Translation regulation
KW-0813--Transport
KW-0832--Ubl conjugation
Interpro

IPR004087--KH_dom
IPR004088--KH_dom_type_1
IPR012677--Nucleotide-bd_a/b_plait
IPR000504--RRM_dom
PROSITE

PS50084--KH_TYPE_1
PS50102--RRM
Pfam

PF00013--KH_1
PF00076--RRM_1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003730--F:mRNA 3'-UTR binding
GO:0048027--F:mRNA 5'-UTR binding
GO:0000166--F:nucleotide binding
GO:0044822--F:poly(A) RNA binding
GO:0003723--F:RNA binding
GO:0045182--F:translation regulator activity
GO:0009653--P:anatomical structure morphogenesis
GO:0010467--P:gene expression
GO:0051028--P:mRNA transport
GO:0017148--P:negative regulation of translation
GO:0042035--P:regulation of cytokine biosynthetic process
GO:0006412--P:translation