dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000087
Uniprot Accession O00423; EMAL1_HUMAN; Q86U15; Q8N536; Q8N5C4; Q8WWL6;
Genbank Protein ID NP_001008707.1; NP_004425.2;
Genbank Nucleotide ID NM_001008707.1; NM_004434.2;
Protein Name Echinoderm microtubule-associated protein-like 1
Protein Synonyms/Alias
Gene Name EML1
Gene Synonyms/Alias EMAP1;EMAPL;EMAPL1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 26 (View all)
PositionPeptidesSourceReferences ( PMIDs )
108TVLPKKPTGSLPSPSPhosphoSitePlus22135298
110LPKKPTGSLPSPSGVPhosphoSitePlus22135298
113KPTGSLPSPSGVRKEdbPTM 3.0;PhosphoSitePlus;UniProt;curated20363803; 16381945; 23193290; 22135298; 24275569; 23911959;
133TKSNIKRTSSSERVSPhosphoSitePlus;curated22135298; 20363803
134KSNIKRTSSSERVSPPhosphoSitePlus22135298
135SNIKRTSSSERVSPGdbPTM 3.0;PhosphoSitePlus;curated20736484; 16381945; 23193290; 22135298; 20363803
136NIKRTSSSERVSPGGPhosphoSitePlus22135298
140TSSSERVSPGGRRESdbPTM 3.0;PhosphoSitePlus;curated20363803; 20736484; 16381945; 23193290; 22135298; 25849741
158SRGNRNRTGSTSSSSPhosphoSitePlus22135298
160GNRNRTGSTSSSSSGPhosphoSitePlus22135298
161NRNRTGSTSSSSSGKPhosphoSitePlus22135298
162RNRTGSTSSSSSGKKPhosphoSitePlus22135298
171SSSGKKNSESKPKEPPhosphoSitePlus;curated22135298; 23186163
173SGKKNSESKPKEPVFPhosphoSitePlus22135298
181KPKEPVFSAEEGYVKPhosphoSitePlus22135298
186VFSAEEGYVKMFLRGdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus18083107; 16381945; 23193290; 19060867; 22135298
396TCGKSHLYFWTLEGSPhosphoSitePlus22135298
448ILVWGKGTNRISYAVPhosphoSitePlus22135298
452GKGTNRISYAVQGAHPhosphoSitePlus22135298
453KGTNRISYAVQGAHEPhosphoSitePlus22135298
Sequence
(Fasta)		MEDGFSSYSS LYDTSSLLQF CNDDSASAAS SMEVTDRIAS LEQRVQMQED DIQLLKSALA 60
DVVRRLNITE EQQAVLNRKG PTKARPLMQT LPLRTTVNNG TVLPKKPTGS LPSPSGVRKE 120
TAVPATKSNI KRTSSSERVS PGGRRESNGD SRGNRNRTGS TSSSSSGKKN SESKPKEPVF 180
SAEEGYVKMF LRGRPVTMYM PKDQVDSYSL EAKVELPTKR LKLEWVYGYR GRDCRNNLYL 240
LPTGETVYFI ASVVVLYNVE EQLQRHYAGH NDDVKCLAVH PDRITIATGQ VAGTSKDGKQ 300
LPPHVRIWDS VTLNTLHVIG IGFFDRAVTC IAFSKSNGGT NLCAVDDSND HVLSVWDWQK 360
EEKLADVKCS NEAVFAADFH PTDTNIIVTC GKSHLYFWTL EGSSLNKKQG LFEKQEKPKF 420
VLCVTFSENG DTITGDSSGN ILVWGKGTNR ISYAVQGAHE GGIFALCMLR DGTLVSGGGK 480
DRKLISWSGN YQKLRKTEIP EQFGPIRTVA EGKGDVILIG TTRNFVLQGT LSGDFTPITQ 540
GHTDELWGLA IHASKSQFLT CGHDKHATLW DAVGHRPVWD KIIEDPAQSS GFHPSGSVVA 600
VGTLTGRWFV FDTETKDLVT VHTDGNEQLS VMRYSPDGNF LAIGSHDNCI YIYGVSDNGR 660
KYTRVGKCSG HSSFITHLDW SVNSQFLVSN SGDYEILYWV PSACKQVVSV ETTRDIEWAT 720
YTCTLGFHVF GVWPEGSDGT DINAVCRAHE KKLLSTGDDF GKVHLFSYPC SQFRAPSHIY 780
GGHSSHVTNV DFLCEDSHLI STGGKDTSIM QWRVI 816
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0887--Epilepsy
KW-0991--Mental retardation
KW-0493--Microtubule
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR005108--HELP
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF03451--HELP
PF00400--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:1990023--C:mitotic spindle midzone
GO:0097431--C:mitotic spindle pole
GO:0048471--C:perinuclear region of cytoplasm
GO:0005509--F:calcium ion binding
GO:0008017--F:microtubule binding
GO:0015631--F:tubulin binding
GO:0007420--P:brain development
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0000226--P:microtubule cytoskeleton organization
GO:0007052--P:mitotic spindle organization
GO:0007405--P:neuroblast proliferation