dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000083
Uniprot Accession O00411; RPOM_HUMAN; O60370;
Genbank Protein ID NP_005026.3;
Genbank Nucleotide ID NM_005035.3;
Protein Name DNA-directed RNA polymerase, mitochondrial
Protein Synonyms/Alias
Gene Name POLRMT
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates.
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
77VRQLQAESVSEVVVNdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19691289; 16381945; 23193290; 18988627; 22135298
115QMGAKDATPVPCGRWdbPTM 3.0;HPRD 919007248; 16381945; 23193290; 18988627
299LTPDLLSYAAALQCMPhosphoSitePlus22135298
315RQDQDAGTIERCLEQPhosphoSitePlus22135298
386AKDGRVSYPKLHLPLPhosphoSitePlus22135298
436HARKTLKTLRDQWEKPhosphoSitePlus22135298
993TRKVVKQTVMTVVYGPhosphoSitePlus22135298
999QTVMTVVYGVTRYGGPhosphoSitePlus22135298
1004VVYGVTRYGGRLQIEPhosphoSitePlus22135298
Sequence
(Fasta)		MSALCWGRGA AGLKRALRPC GRPGLPGKEG TAGGVCGPRR SSSASPQEQD QDRRKDWGHV 60
ELLEVLQARV RQLQAESVSE VVVNRVDVAR LPECGSGDGS LQPPRKVQMG AKDATPVPCG 120
RWAKILEKDK RTQQMRMQRL KAKLQMPFQS GEFKALTRRL QVEPRLLSKQ MAGCLEDCTR 180
QAPESPWEEQ LARLLQEAPG KLSLDVEQAP SGQHSQAQLS GQQQRLLAFF KCCLLTDQLP 240
LAHHLLVVHH GQRQKRKLLT LDMYNAVMLG WARQGAFKEL VYVLFMVKDA GLTPDLLSYA 300
AALQCMGRQD QDAGTIERCL EQMSQEGLKL QALFTAVLLS EEDRATVLKA VHKVKPTFSL 360
PPQLPPPVNT SKLLRDVYAK DGRVSYPKLH LPLKTLQCLF EKQLHMELAS RVCVVSVEKP 420
TLPSKEVKHA RKTLKTLRDQ WEKALCRALR ETKNRLEREV YEGRFSLYPF LCLLDEREVV 480
RMLLQVLQAL PAQGESFTTL ARELSARTFS RHVVQRQRVS GQVQALQNHY RKYLCLLASD 540
AEVPEPCLPR QYWEELGAPE ALREQPWPLP VQMELGKLLA EMLVQATQMP CSLDKPHRSS 600
RLVPVLYHVY SFRNVQQIGI LKPHPAYVQL LEKAAEPTLT FEAVDVPMLC PPLPWTSPHS 660
GAFLLSPTKL MRTVEGATQH QELLETCPPT ALHGALDALT QLGNCAWRVN GRVLDLVLQL 720
FQAKGCPQLG VPAPPSEAPQ PPEAHLPHSA APARKAELRR ELAHCQKVAR EMHSLRAEAL 780
YRLSLAQHLR DRVFWLPHNM DFRGRTYPCP PHFNHLGSDV ARALLEFAQG RPLGPHGLDW 840
LKIHLVNLTG LKKREPLRKR LAFAEEVMDD ILDSADQPLT GRKWWMGAEE PWQTLACCME 900
VANAVRASDP AAYVSHLPVH QDGSCNGLQH YAALGRDSVG AASVNLEPSD VPQDVYSGVA 960
AQVEVFRRQD AQRGMRVAQV LEGFITRKVV KQTVMTVVYG VTRYGGRLQI EKRLRELSDF 1020
PQEFVWEASH YLVRQVFKSL QEMFSGTRAI QHWLTESARL ISHMGSVVEW VTPLGVPVIQ 1080
PYRLDSKVKQ IGGGIQSITY THNGDISRKP NTRKQKNGFP PNFIHSLDSS HMMLTALHCY 1140
RKGLTFVSVH DCYWTHAADV SVMNQVCREQ FVRLHSEPIL QDLSRFLVKR FCSEPQKILE 1200
ASQLKETLQA VPKPGAFDLE QVKRSTYFFS 1231
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0240--DNA-directed RNA polymerase
KW-0496--Mitochondrion
KW-0548--Nucleotidyltransferase
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0808--Transferase
KW-0809--Transit peptide
Interpro

IPR024075--DNA-dir_RNA_pol_helix_hairpin
IPR002092--DNA-dir_Rpol_phage-type
IPR029262--RPOL_N
PROSITE

PS00900--RNA_POL_PHAGE_1
PS00489--RNA_POL_PHAGE_2
Pfam

PF00940--RNA_pol
PF14700--RPOL_N
Gene Ontology

GO:0005759--C:mitochondrial matrix
GO:0042645--C:mitochondrial nucleoid
GO:0005739--C:mitochondrion
GO:0003677--F:DNA binding
GO:0003899--F:DNA-directed RNA polymerase activity
GO:0044822--F:poly(A) RNA binding
GO:0010467--P:gene expression
GO:0007005--P:mitochondrion organization
GO:0006996--P:organelle organization
GO:0006390--P:transcription from mitochondrial promoter
GO:0006391--P:transcription initiation from mitochondrial promoter