dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000082
Uniprot Accession O00410; IPO5_HUMAN; B4DZA0; O15257; Q5T578; Q86XC7;
Genbank Protein ID NP_002262.3; XP_005254109.1; XP_005254110.1; XP_011519389.1; XP_011519390.1; XP_011519391.1; XP_011519392.1;
Genbank Nucleotide ID NM_002271.4; XM_005254052.2; XM_005254053.2; XM_011521087.1; XM_011521088.1; XM_011521089.1; XM_011521090.1;
Protein Name Importin-5
Protein Synonyms/Alias
Gene Name IPO5
Gene Synonyms/Alias KPNB3;RANBP5;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.
Phosphorylation Sites
 dbPAF PTMs: 19
PositionPeptidesSourceReferences ( PMIDs )
20LLLGNLLSPDNVVRKdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 25627689
71VLLRRLLSSAFDEVYHPRD 918452278; 18988627
72LLRRLLSSAFDEVYPPhosphoSitePlus22135298
83EVYPALPSDVQTAIKHPRD 918452278; 18988627
239NDDSVLKSLVEIADTPhosphoSitePlus;curated22135298; 23911959
258LRPHLEATLQLSLKLPHOSIDA21081558
304HTNIVAQTIPQMLAMdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated18691976; 16381945; 23193290; 18988627; 21081558; 22135298;
491NLVKHLHSIMVLKLQdbPTM 3.0;PhosphoSitePlus21060948; 16381945; 23193290; 22135298
557LRLLRGKTIECISLIPHOSIDA21081558
562GKTIECISLIGLAVGPHOSIDA21081558
578EKFMQDASDVMQLLLPHOSIDA21081558
633VMGPLMKTASIKPEVdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus18669648; 16381945; 23193290; 18988627; 22135298
635GPLMKTASIKPEVALPhosphoSitePlus;curated22135298; 24667141
645PEVALLDTQDMENMSdbPTM 3.0;PhosphoSitePlus;curated21659604; 16381945; 23193290; 22135298; 23898821
652TQDMENMSDDDGWEFdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated18691976; 16381945; 23193290; 18669648; 21659604; 18452278;
680AGLEEKSTACQMLVCPhosphoSitePlus22135298
820VKRQDEDYDEQVEESPhosphoSitePlus22135298
827YDEQVEESLQDEDDNdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18669648; 18691976; 19690332; 16381945; 23193290;
1040TNLPKIFSIIAEGEMPhosphoSitePlus22135298
Sequence
(Fasta)		MAAAAAEQQQ FYLLLGNLLS PDNVVRKQAE ETYENIPGQS KITFLLQAIR NTTAAEEARQ 60
MAAVLLRRLL SSAFDEVYPA LPSDVQTAIK SELLMIIQME TQSSMRKKVC DIAAELARNL 120
IDEDGNNQWP EGLKFLFDSV SSQNVGLREA ALHIFWNFPG IFGNQQQHYL DVIKRMLVQC 180
MQDQEHPSIR TLSARATAAF ILANEHNVAL FKHFADLLPG FLQAVNDSCY QNDDSVLKSL 240
VEIADTVPKY LRPHLEATLQ LSLKLCGDTS LNNMQRQLAL EVIVTLSETA AAMLRKHTNI 300
VAQTIPQMLA MMVDLEEDED WANADELEDD DFDSNAVAGE SALDRMACGL GGKLVLPMIK 360
EHIMQMLQNP DWKYRHAGLM ALSAIGEGCH QQMEGILNEI VNFVLLFLQD PHPRVRYAAC 420
NAVGQMATDF APGFQKKFHE KVIAALLQTM EDQGNQRVQA HAAAALINFT EDCPKSLLIP 480
YLDNLVKHLH SIMVLKLQEL IQKGTKLVLE QVVTSIASVA DTAEEKFVPY YDLFMPSLKH 540
IVENAVQKEL RLLRGKTIEC ISLIGLAVGK EKFMQDASDV MQLLLKTQTD FNDMEDDDPQ 600
ISYMISAWAR MCKILGKEFQ QYLPVVMGPL MKTASIKPEV ALLDTQDMEN MSDDDGWEFV 660
NLGDQQSFGI KTAGLEEKST ACQMLVCYAK ELKEGFVEYT EQVVKLMVPL LKFYFHDGVR 720
VAAAESMPLL LECARVRGPE YLTQMWHFMC DALIKAIGTE PDSDVLSEIM HSFAKCIEVM 780
GDGCLNNEHF EELGGILKAK LEEHFKNQEL RQVKRQDEDY DEQVEESLQD EDDNDVYILT 840
KVSDILHSIF SSYKEKVLPW FEQLLPLIVN LICPHRPWPD RQWGLCIFDD VIEHCSPASF 900
KYAEYFLRPM LQYVCDNSPE VRQAAAYGLG VMAQYGGDNY RPFCTEALPL LVRVIQSADS 960
KTKENVNATE NCISAVGKIM KFKPDCVNVE EVLPHWLSWL PLHEDKEEAV QTFNYLCDLI 1020
ESNHPIVLGP NNTNLPKIFS IIAEGEMHEA IKHEDPCAKR LANVVRQVQT SGGLWTECIA 1080
QLSPEQQAAI QELLNSA 1098
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0945--Host-virus interaction
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000357--HEAT
IPR001494--Importin-beta_N
PROSITE

PS50166--IMPORTIN_B_NT
Pfam

PF02985--HEAT
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005794--C:Golgi apparatus
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016020--C:membrane
GO:0031965--C:nuclear membrane
GO:0034399--C:nuclear periphery
GO:0005643--C:nuclear pore
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005095--F:GTPase inhibitor activity
GO:0008139--F:nuclear localization sequence binding
GO:0044822--F:poly(A) RNA binding
GO:0008565--F:protein transporter activity
GO:0008536--F:Ran GTPase binding
GO:0071230--P:cellular response to amino acid stimulus
GO:0034260--P:negative regulation of GTPase activity
GO:0006607--P:NLS-bearing protein import into nucleus
GO:0042307--P:positive regulation of protein import into nucleus
GO:0000059--P:protein import into nucleus, docking
GO:0000060--P:protein import into nucleus, translocation
GO:0006610--P:ribosomal protein import into nucleus
GO:0016032--P:viral process