dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000081
Uniprot Accession O00409; FOXN3_HUMAN; Q96II7; Q9UIE7;
Genbank Protein ID NP_001078940.1; NP_005188.2;
Genbank Nucleotide ID NM_001085471.1; NM_005197.3;
Protein Name Forkhead box protein N3
Protein Synonyms/Alias Checkpoint suppressor 1;
Gene Name FOXN3
Gene Synonyms/Alias C14orf116;CHES1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).
Phosphorylation Sites
 dbPAF PTMs: 19
PositionPeptidesSourceReferences ( PMIDs )
8MGPVMPPSKKPESSGdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 22817900
14PSKKPESSGISVSSGPhosphoSitePlus22135298
83FGESVLRSVSPVQDLdbPTM 3.0;PhosphoSitePlus;curated19690332; 16381945; 23193290; 22135298; 22817900; 26074081
85ESVLRSVSPVQDLDDdbPTM 3.0;PhosphoSitePlus;UniProt;curated19690332; 16381945; 23193290; 22135298; 22115753; 22817900;
94VQDLDDDTPPSPAHScurated26074081
97LDDDTPPSPAHSDMPPhosphoSitePlus;curated22135298; 19690332; 22817900
101TPPSPAHSDMPYDARdbPTM 3.0;PhosphoSitePlus;curated19690332; 16381945; 23193290; 22135298; 22817900
105PAHSDMPYDARQNPNcurated19690332
167NSVRHNLSLNKCFKKPhosphoSitePlus22135298
297GVRPLPITPIGVTAAPhosphoSitePlus22135298
316ITSCRMRTESEPSCGPhosphoSitePlus22135298
318SCRMRTESEPSCGSPPhosphoSitePlus22135298
324ESEPSCGSPVVSGDPPhosphoSitePlus22135298
349SSNARSTSPTSDSIScurated25627689; 24961811
352ARSTSPTSDSISSSScurated26074081
391FRSHESPSDTEEDDRcurated25849741
412PKDSLGDSGYASQHKPhosphoSitePlus;curated22135298; 25627689
432AKARKVPSDTLPLKKPhosphoSitePlus22135298
448RTEKPPESDDEEMKEPhosphoSitePlus;curated22135298; 23186163
Sequence
(Fasta)		MGPVMPPSKK PESSGISVSS GLSQCYGGSG FSKALQEDDD LDFSLPDIRL EEGAMEDEEL 60
TNLNWLHESK NLLKSFGESV LRSVSPVQDL DDDTPPSPAH SDMPYDARQN PNCKPPYSFS 120
CLIFMAIEDS PTKRLPVKDI YNWILEHFPY FANAPTGWKN SVRHNLSLNK CFKKVDKERS 180
QSIGKGSLWC IDPEYRQNLI QALKKTPYHP HPHVFNTPPT CPQAYQSTSG PPIWPGSTFF 240
KRNGALLQDP DIDAASAMML LNTPPEIQAG FPPGVIQNGA RVLSRGLFPG VRPLPITPIG 300
VTAAMRNGIT SCRMRTESEP SCGSPVVSGD PKEDHNYSSA KSSNARSTSP TSDSISSSSS 360
SADDHYEFAT KGSQEGSEGS EGSFRSHESP SDTEEDDRKH SQKEPKDSLG DSGYASQHKK 420
RQHFAKARKV PSDTLPLKKR RTEKPPESDD EEMKEAAGSL LHLAGIRSCL NNITNRTAKG 480
QKEQKETTKN 491
Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR001766--Fork_head_dom
IPR018122--TF_fork_head_CS_1
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS00657--FORK_HEAD_1
PS00658--FORK_HEAD_2
PS50039--FORK_HEAD_3
Pfam

PF00250--Forkhead
Gene Ontology

GO:0005634--C:nucleus
GO:0008022--F:protein C-terminus binding
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0007095--P:mitotic G2 DNA damage checkpoint
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated