| Tag |
Content |
| dbPAF ID |
dbPAF-0000080 |
| Uniprot Accession |
O00408; PDE2A_HUMAN; B2R646; B3KRV5; E9PGI1; F6W5Z0; Q5J791; Q5J792; Q5J793; Q6ZMR1;
|
| Genbank Protein ID |
NP_001137311.1; NP_001139681.1; NP_001230713.1; NP_002590.1;
|
| Genbank Nucleotide ID |
NM_001143839.3; NM_001146209.2; NM_001243784.1; NM_002599.4;
|
| Protein Name |
cGMP-dependent 3',5'-cyclic phosphodiesterase |
| Protein Synonyms/Alias |
Cyclic GMP-stimulated phosphodiesterase;CGS-PDE;cGSPDE; |
| Gene Name |
PDE2A |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.Functional Description
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. |
Phosphorylation Sites
|
dbPAF PTMs: 10 |
Sequence
(Fasta) | MGQACGHSIL CRSQQYPAAR PAEPRGQQVF LKPDEPPPPP QPCADSLQDA LLSLGSVIDI 60
SGLQRAVKEA LSAVLPRVET VYTYLLDGES QLVCEDPPHE LPQEGKVREA IISQKRLGCN 120
GLGFSDLPGK PLARLVAPLA PDTQVLVMPL ADKEAGAVAA VILVHCGQLS DNEEWSLQAV 180
EKHTLVALRR VQVLQQRGPR EAPRAVQNPP EGTAEDQKGG AAYTDRDRKI LQLCGELYDL 240
DASSLQLKVL QYLQQETRAS RCCLLLVSED NLQLSCKVIG DKVLGEEVSF PLTGCLGQVV 300
EDKKSIQLKD LTSEDVQQLQ SMLGCELQAM LCVPVISRAT DQVVALACAF NKLEGDLFTD 360
EDEHVIQHCF HYTSTVLTST LAFQKEQKLK CECQALLQVA KNLFTHLDDV SVLLQEIITE 420
ARNLSNAEIC SVFLLDQNEL VAKVFDGGVV DDESYEIRIP ADQGIAGHVA TTGQILNIPD 480
AYAHPLFYRG VDDSTGFRTR NILCFPIKNE NQEVIGVAEL VNKINGPWFS KFDEDLATAF 540
SIYCGISIAH SLLYKKVNEA QYRSHLANEM MMYHMKVSDD EYTKLLHDGI QPVAAIDSNF 600
ASFTYTPRSL PEDDTSMAIL SMLQDMNFIN NYKIDCPTLA RFCLMVKKGY RDPPYHNWMH 660
AFSVSHFCYL LYKNLELTNY LEDIEIFALF ISCMCHDLDH RGTNNSFQVA SKSVLAALYS 720
SEGSVMERHH FAQAIAILNT HGCNIFDHFS RKDYQRMLDL MRDIILATDL AHHLRIFKDL 780
QKMAEVGYDR NNKQHHRLLL CLLMTSCDLS DQTKGWKTTR KIAELIYKEF FSQGDLEKAM 840
GNRPMEMMDR EKAYIPELQI SFMEHIAMPI YKLLQDLFPK AAELYERVAS NREHWTKVSH 900
KFTIRGLPSN NSLDFLDEEY EVPDLDGTRA PINGCCSLDA E
942Fasta Sequence
>O00408|PDE2A|Homo sapiens(Human)
MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0114--cAMP
KW-1003--Cell membrane
KW-0140--cGMP
KW-0142--cGMP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0564--Palmitate
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
|
| Interpro |
IPR003018--GAF
IPR029016--GAF_dom-like
IPR003607--HD/PDEase_dom
IPR023088--PDEase
IPR002073--PDEase_catalytic_dom
IPR023174--PDEase_CS
|
| PROSITE |
PS00126--PDEASE_I
|
| Pfam |
PF01590--GAF
PF13185--GAF_2
PF00233--PDEase_I
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005794--C:Golgi apparatus
GO:0045121--C:membrane raft
GO:0005759--C:mitochondrial matrix
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0042734--C:presynaptic membrane
GO:0005262--F:calcium channel activity
GO:0030552--F:cAMP binding
GO:0030553--F:cGMP binding
GO:0004118--F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
GO:0004112--F:cyclic-nucleotide phosphodiesterase activity
GO:0008144--F:drug binding
GO:0046872--F:metal ion binding
GO:0042803--F:protein homodimerization activity
GO:0030911--F:TPR domain binding
GO:0007596--P:blood coagulation
GO:0070588--P:calcium ion transmembrane transport
GO:0006198--P:cAMP catabolic process
GO:0019933--P:cAMP-mediated signaling
GO:0071321--P:cellular response to cGMP
GO:0035690--P:cellular response to drug
GO:0097011--P:cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:0036006--P:cellular response to macrophage colony-stimulating factor stimulus
GO:0071260--P:cellular response to mechanical stimulus
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0046069--P:cGMP catabolic process
GO:0019934--P:cGMP-mediated signaling
GO:0061028--P:establishment of endothelial barrier
GO:0008152--P:metabolic process
GO:0030224--P:monocyte differentiation
GO:0030818--P:negative regulation of cAMP biosynthetic process
GO:0033159--P:negative regulation of protein import into nucleus, translocation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0043116--P:negative regulation of vascular permeability
GO:0050729--P:positive regulation of inflammatory response
GO:0043117--P:positive regulation of vascular permeability
GO:0006626--P:protein targeting to mitochondrion
|
