dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000079
Uniprot Accession O00401; WASL_HUMAN; A1JUI9; Q7Z746;
Genbank Protein ID NP_003932.3;
Genbank Nucleotide ID NM_003941.3;
Protein Name Neural Wiskott-Aldrich syndrome protein
Protein Synonyms/Alias
Gene Name WASL
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression.
Phosphorylation Sites
 dbPAF PTMs: 22 (View all)
PositionPeptidesSourceReferences ( PMIDs )
58ADRNCMWSKKCSGVAPhosphoSitePlus22135298
95LLWEQELYNNFVYNSPhosphoSitePlus22135298
100ELYNNFVYNSPRGYFPhosphoSitePlus22135298
102YNNFVYNSPRGYFHTPhosphoSitePlus22135298
135KKFRKAVTDLLGRRQPhosphoSitePlus22135298
171IKNPEITTNRFYGPQcurated25627689
175EITTNRFYGPQVNNIdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated16199863; 16381945; 23193290; 18988627; 22135298; 25627689
183GPQVNNISHTKEKKKPhosphoSitePlus;curated22135298; 25627689
185QVNNISHTKEKKKGKcurated25627689
205LTKADIGTPSNFQHIPhosphoSitePlus;curated22135298; 25627689
207KADIGTPSNFQHIGHcurated25627689
242LFDMCGISEAQLKDRdbPTM 3.0;PhosphoPep 2.016257963; 16381945; 23193290; 19060867
256RETSKVIYDFIEKTGdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated16257963; 17389395; 18083107; 19534553; 16381945; 23193290;
426LKKVEQNSRPVSCSGcurated23898821
430EQNSRPVSCSGRDALdbPTM 3.0;PhosphoSitePlus;curated20363803; 16381945; 23193290; 22135298; 25627689; 23898821;
432NSRPVSCSGRDALLDcurated23898821
456SVADGQESTPPTPAPPhosphoSitePlus;curated22135298; 25627689
457VADGQESTPPTPAPTPhosphoSitePlus;curated22135298; 25627689; 22199227
460GQESTPPTPAPTSGIPhosphoSitePlus22135298
464TPPTPAPTSGIVGALPhosphoSitePlus22135298
Sequence
(Fasta)		MSSVQQQPPP PRRVTNVGSL LLTPQENESL FTFLGKKCVT MSSAVVQLYA ADRNCMWSKK 60
CSGVACLVKD NPQRSYFLRI FDIKDGKLLW EQELYNNFVY NSPRGYFHTF AGDTCQVALN 120
FANEEEAKKF RKAVTDLLGR RQRKSEKRRD PPNGPNLPMA TVDIKNPEIT TNRFYGPQVN 180
NISHTKEKKK GKAKKKRLTK ADIGTPSNFQ HIGHVGWDPN TGFDLNNLDP ELKNLFDMCG 240
ISEAQLKDRE TSKVIYDFIE KTGGVEAVKN ELRRQAPPPP PPSRGGPPPP PPPPHNSGPP 300
PPPARGRGAP PPPPSRAPTA APPPPPPSRP SVAVPPPPPN RMYPPPPPAL PSSAPSGPPP 360
PPPSVLGVGP VAPPPPPPPP PPPGPPPPPG LPSDGDHQVP TTAGNKAALL DQIREGAQLK 420
KVEQNSRPVS CSGRDALLDQ IRQGIQLKSV ADGQESTPPT PAPTSGIVGA LMEVMQKRSK 480
AIHSSDEDED EDDEEDFEDD DEWED 506
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0009--Actin-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR000095--CRIB_dom
IPR030214--N-WASP
IPR011993--PH/PTB_dom
IPR011026--WASP_C
IPR000697--WH1/EVH1_dom
IPR003124--WH2_dom
PROSITE

PS50108--CRIB
PS50229--WH1
PS51082--WH2
Pfam

PF00786--PBD
PF00568--WH1
PF02205--WH2
Gene Ontology

GO:0030478--C:actin cap
GO:0015629--C:actin cytoskeleton
GO:0016023--C:cytoplasmic membrane-bounded vesicle
GO:0005829--C:cytosol
GO:0030666--C:endocytic vesicle membrane
GO:0070062--C:extracellular exosome
GO:0000139--C:Golgi membrane
GO:0030027--C:lamellipodium
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0030695--F:GTPase regulator activity
GO:0008154--P:actin polymerization or depolymerization
GO:0007411--P:axon guidance
GO:0051301--P:cell division
GO:0034629--P:cellular protein complex localization
GO:0048013--P:ephrin receptor signaling pathway
GO:0038096--P:Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087--P:innate immune response
GO:0006900--P:membrane budding
GO:0007067--P:mitotic nuclear division
GO:0006928--P:movement of cell or subcellular component
GO:2000402--P:negative regulation of lymphocyte migration
GO:1903526--P:negative regulation of membrane tubulation
GO:0046209--P:nitric oxide metabolic process
GO:2000370--P:positive regulation of clathrin-mediated endocytosis
GO:0051491--P:positive regulation of filopodium assembly
GO:0006461--P:protein complex assembly
GO:0050999--P:regulation of nitric-oxide synthase activity
GO:0032880--P:regulation of protein localization
GO:0006355--P:regulation of transcription, DNA-templated
GO:0009617--P:response to bacterium
GO:0007264--P:small GTPase mediated signal transduction
GO:0044281--P:small molecule metabolic process
GO:0051653--P:spindle localization
GO:0006351--P:transcription, DNA-templated
GO:0016050--P:vesicle organization
GO:0030050--P:vesicle transport along actin filament