dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000076
Uniprot Accession O00391; QSOX1_HUMAN; Q59G29; Q5T2X0; Q8TDL6; Q8WVP4;
Genbank Protein ID NP_001004128.1; NP_002817.2;
Genbank Nucleotide ID NM_001004128.2; NM_002826.4;
Protein Name Sulfhydryl oxidase 1
Protein Synonyms/Alias
Gene Name QSOX1
Gene Synonyms/Alias QSCN6;UNQ2520/PRO6013;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation.
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
49LTLLQADTVRGAVLGPhosphoSitePlus22135298
255RVPVLMESRSFYTAYdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated15302935; 16381945; 23193290; 18988627; 22135298; 19366988;
300LADRSKIYMADLESAdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298;
306IYMADLESALHYILRdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298;
426ARQNVDHSQEAAKAKcurated25849741; 24972180
576LELESRNSTLDPGKPPhosphoSitePlus22135298
577ELESRNSTLDPGKPEPhosphoSitePlus22135298
588GKPEMMKSPTNTTPHPhosphoSitePlus22135298
590PEMMKSPTNTTPHVPPhosphoSitePlus22135298
592MMKSPTNTTPHVPAEPhosphoSitePlus22135298
593MKSPTNTTPHVPAEGPhosphoSitePlus22135298
Sequence
(Fasta)		MRRCNSGSGP PPSLLLLLLW LLAVPGANAA PRSALYSPSD PLTLLQADTV RGAVLGSRSA 60
WAVEFFASWC GHCIAFAPTW KALAEDVKAW RPALYLAALD CAEETNSAVC RDFNIPGFPT 120
VRFFKAFTKN GSGAVFPVAG ADVQTLRERL IDALESHHDT WPPACPPLEP AKLEEIDGFF 180
ARNNEEYLAL IFEKGGSYLG REVALDLSQH KGVAVRRVLN TEANVVRKFG VTDFPSCYLL 240
FRNGSVSRVP VLMESRSFYT AYLQRLSGLT REAAQTTVAP TTANKIAPTV WKLADRSKIY 300
MADLESALHY ILRIEVGRFP VLEGQRLVAL KKFVAVLAKY FPGRPLVQNF LHSVNEWLKR 360
QKRNKIPYSF FKTALDDRKE GAVLAKKVNW IGCQGSEPHF RGFPCSLWVL FHFLTVQAAR 420
QNVDHSQEAA KAKEVLPAIR GYVHYFFGCR DCASHFEQMA AASMHRVGSP NAAVLWLWSS 480
HNRVNARLAG APSEDPQFPK VQWPPRELCS ACHNERLDVP VWDVEATLNF LKAHFSPSNI 540
ILDFPAAGSA ARRDVQNVAA APELAMGALE LESRNSTLDP GKPEMMKSPT NTTPHVPAEG 600
PEASRPPKLH PGLRAAPGQE PPEHMAELQR NEQEQPLGQW HLSKRDTGAA LLAESRAEKN 660
RLWGPLEVRR VGRSSKQLVD IPEGQLEARA GRGRGQWLQV LGGGFSYLDI SLCVGLYSLS 720
FMGLLAMYTY FQAKIRALKG HAGHPAA 748
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0274--FAD
KW-0285--Flavoprotein
KW-0325--Glycoprotein
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR017905--ERV/ALR_sulphydryl_oxidase
IPR012336--Thioredoxin-like_fold
IPR013766--Thioredoxin_domain
PROSITE

PS51324--ERV_ALR
PS51352--THIOREDOXIN_2
Pfam

PF04777--Evr1_Alr
PF00085--Thioredoxin
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0005794--C:Golgi apparatus
GO:0030173--C:integral component of Golgi membrane
GO:0045171--C:intercellular bridge
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016971--F:flavin-linked sulfhydryl oxidase activity
GO:0003756--F:protein disulfide isomerase activity
GO:0045454--P:cell redox homeostasis
GO:0016242--P:negative regulation of macroautophagy
GO:0006457--P:protein folding