dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000073
Uniprot Accession O00341; EAA5_HUMAN; Q5VVZ0; Q969Z8; Q9BW45;
Genbank Protein ID NP_001274525.1; NP_001274526.1; NP_006662.3;
Genbank Nucleotide ID NM_001287596.1; NM_001287597.1; NM_006671.5;
Protein Name Excitatory amino acid transporter 5
Protein Synonyms/Alias Retinal glutamate transporter;Solute carrier family 1 member 7;
Gene Name SLC1A7
Gene Synonyms/Alias EAAT5;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
79SLMSGLASLDAKTSSPhosphoSitePlus22135298
95LGVLTVAYYLWTTFMPhosphoSitePlus22135298
Sequence
(Fasta)		MVPHAILARG RDVCRRNGLL ILSVLSVIVG CLLGFFLRTR RLSPQEISYF QFPGELLMRM 60
LKMMILPLVV SSLMSGLASL DAKTSSRLGV LTVAYYLWTT FMAVIVGIFM VSIIHPGSAA 120
QKETTEQSGK PIMSSADALL DLIRNMFPAN LVEATFKQYR TKTTPVVKSP KVAPEEAPPR 180
RILIYGVQEE NGSHVQNFAL DLTPPPEVVY KSEPGTSDGM NVLGIVFFSA TMGIMLGRMG 240
DSGAPLVSFC QCLNESVMKI VAVAVWYFPF GIVFLIAGKI LEMDDPRAVG KKLGFYSVTV 300
VCGLVLHGLF ILPLLYFFIT KKNPIVFIRG ILQALLIALA TSSSSATLPI TFKCLLENNH 360
IDRRIARFVL PVGATINMDG TALYEAVAAI FIAQVNNYEL DFGQIITISI TATAASIGAA 420
GIPQAGLVTM VIVLTSVGLP TDDITLIIAV DWALDRFRTM INVLGDALAA GIMAHICRKD 480
FARDTGTEKL LPCETKPVSL QEIVAAQQNG CVKSVAEASE LTLGPTCPHH VPVQVEQDEE 540
LPAASLNHCT IQISELETNV 561
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0769--Symport
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
Interpro

IPR001991--Na-dicarboxylate_symporter
IPR018107--Na-dicarboxylate_symporter_CS
PROSITE

PS00713--NA_DICARBOXYL_SYMP_1
PS00714--NA_DICARBOXYL_SYMP_2
Pfam

PF00375--SDF
Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0005313--F:L-glutamate transmembrane transporter activity
GO:0017153--F:sodium:dicarboxylate symporter activity
GO:0006835--P:dicarboxylic acid transport
GO:0014047--P:glutamate secretion
GO:0006811--P:ion transport
GO:0089711--P:L-glutamate transmembrane transport
GO:0007269--P:neurotransmitter secretion
GO:0007268--P:synaptic transmission
GO:0055085--P:transmembrane transport