dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0000070 |
| Uniprot Accession | O00337; S28A1_HUMAN; A0AV42; A8K7I2; O00335; O00336; Q5U5S6; Q5U648; Q9UEZ9; |
| Genbank Protein ID | NP_001274691.1; NP_004204.3; NP_964014.1; |
| Genbank Nucleotide ID | NM_001287762.1; NM_004213.4; NM_201651.2; |
| Protein Name | Sodium/nucleoside cotransporter 1 |
| Protein Synonyms/Alias | Concentrative nucleoside transporter 1;CNT 1;hCNT1;Na(+)/nucleoside cotransporter 1;Sodium-coupled nucleoside transporter 1;Solute carrier family 28 member 1; |
| Gene Name | SLC28A1 |
| Gene Synonyms/Alias | CNT1; |
| Organism | Homo sapiens(Human) |
| NCBI Taxa ID | 9606 |
| Functional Description (View all) |
Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine. |
| Phosphorylation Sites |
dbPAF PTMs: 5 |
| Sequence (Fasta) | MENDPSRRRE SISLTPVAKG LENMGADFLE SLEEGQLPRS DLSPAEIRSS WSEAAPKPFS 60 RWRNLQPALR ARSFCREHMQ LFRWIGTGLL CTGLSAFLLV ACLLDFQRAL ALFVLTCVVL 120 TFLGHRLLKR LLGPKLRRFL KPQGHPRLLL WFKRGLALAA FLGLVLWLSL DTSQRPEQLV 180 SFAGICVFVA LLFACSKHHC AVSWRAVSWG LGLQFVLGLL VIRTEPGFIA FEWLGEQIRI 240 FLSYTKAGSS FVFGEALVKD VFAFQVLPII VFFSCVISVL YHVGLMQWVI LKIAWLMQVT 300 MGTTATETLS VAGNIFVSQT EAPLLIRPYL ADMTLSEVHV VMTGGYATIA GSLLGAYISF 360 GIDATSLIAA SVMAAPCALA LSKLVYPEVE ESKFRREEGV KLTYGDAQNL IEAASTGAAI 420 SVKVVANIAA NLIAFLAVLD FINAALSWLG DMVDIQGLSF QLICSYILRP VAFLMGVAWE 480 DCPVVAELLG IKLFLNEFVA YQDLSKYKQR RLAGAEEWVG DRKQWISVRA EVLTTFALCG 540 FANFSSIGIM LGGLTSMVPQ RKSDFSQIVL RALFTGACVS LVNACMAGIL YMPRGAEVDC 600 MSLLNTTLSS SSFEIYQCCR EAFQSVNPEF SPEALDNCCR FYNHTICAQ |
| Keyword | KW-0025--Alternative splicing |
| Interpro | IPR008276--C_nuclsd_transpt |
| PROSITE | |
| Pfam | |
| Gene Ontology | GO:0005887--C:integral component of plasma membrane |