dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000069
Uniprot Accession O00330; ODPX_HUMAN; B4DW62; D3DR11; E9PB14; E9PBP7; O60221; Q96FV8; Q99783;
Genbank Protein ID NP_001128496.1; NP_001159630.1; NP_003468.2;
Genbank Nucleotide ID NM_001135024.1; NM_001166158.1; NM_003477.2;
Protein Name Pyruvate dehydrogenase protein X component, mitochondrial
Protein Synonyms/Alias Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex;E3-binding protein;E3BP;Lipoyl-containing pyruvate dehydrogenase complex component X;proX;
Gene Name PDHX
Gene Synonyms/Alias PDX1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
16CDPRLLRYLVGFPGRPhosphoSitePlus22135298
25VGFPGRRSVGLVKGAPhosphoSitePlus22135298
65KILMPSLSPTMEEGNcurated25850435
162KPSEPRPSPEPQISIdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated18491316; 16381945; 23193290; 18988627; 22135298; 25627689;
168PSPEPQISIPVKKEHdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated18491316; 16381945; 23193290; 18988627; 22135298; 25627689;
179KKEHIPGTLRFRLSPPhosphoSitePlus22135298
196RNILEKHSLDASQGTPhosphoSitePlus;UniProt22135298; 24275569
200EKHSLDASQGTATGPPhosphoSitePlus22135298
Sequence
(Fasta)		MAASWRLGCD PRLLRYLVGF PGRRSVGLVK GALGWSVSRG ANWRWFHSTQ WLRGDPIKIL 60
MPSLSPTMEE GNIVKWLKKE GEAVSAGDAL CEIETDKAVV TLDASDDGIL AKIVVEEGSK 120
NIRLGSLIGL IVEEGEDWKH VEIPKDVGPP PPVSKPSEPR PSPEPQISIP VKKEHIPGTL 180
RFRLSPAARN ILEKHSLDAS QGTATGPRGI FTKEDALKLV QLKQTGKITE SRPTPAPTAT 240
PTAPSPLQAT AGPSYPRPVI PPVSTPGQPN AVGTFTEIPA SNIRRVIAKR LTESKSTVPH 300
AYATADCDLG AVLKVRQDLV KDDIKVSVND FIIKAAAVTL KQMPDVNVSW DGEGPKQLPF 360
IDISVAVATD KGLLTPIIKD AAAKGIQEIA DSVKALSKKA RDGKLLPEEY QGGSFSISNL 420
GMFGIDEFTA VINPPQACIL AVGRFRPVLK LTEDEEGNAK LQQRQLITVT MSSDSRVVDD 480
ELATRFLKSF KANLENPIRL A 502
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0450--Lipoyl
KW-0496--Mitochondrion
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0809--Transit peptide
Interpro

IPR003016--2-oxoA_DH_lipoyl-BS
IPR001078--2-oxoacid_DH_actylTfrase
IPR000089--Biotin_lipoyl
IPR023213--CAT-like_dom
IPR004167--E3-bd
IPR011053--Single_hybrid_motif
PROSITE

PS50968--BIOTINYL_LIPOYL
PS00189--LIPOYL
Pfam

PF00198--2-oxoacid_dh
PF00364--Biotin_lipoyl
PF02817--E3_binding
Gene Ontology

GO:0005759--C:mitochondrial matrix
GO:0045254--C:pyruvate dehydrogenase complex
GO:0016746--F:transferase activity, transferring acyl groups
GO:0044237--P:cellular metabolic process
GO:0061732--P:mitochondrial acetyl-CoA biosynthetic process from pyruvate
GO:0006090--P:pyruvate metabolic process
GO:0010510--P:regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0044281--P:small molecule metabolic process