dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000065
Uniprot Accession O00311; CDC7_HUMAN; D3DT31; O00558; Q5T5U5;
Genbank Protein ID NP_001127891.1; NP_001127892.1; NP_003494.1; XP_005271298.1; XP_011540528.1;
Genbank Nucleotide ID NM_001134419.1; NM_001134420.1; NM_003503.3; XM_005271241.2; XM_011542226.1;
Protein Name Cell division cycle 7-related protein kinase
Protein Synonyms/Alias
Gene Name CDC7
Gene Synonyms/Alias CDC7L1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.
Phosphorylation Sites
 dbPAF PTMs: 25 (View all)
PositionPeptidesSourceReferences ( PMIDs )
16MDEPMAFSPQRDRFQdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated18691976; 16381945; 23193290; 18988627; 21081558; 22135298;
27DRFQAEGSLKKNEQNdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18691976; 19369195; 16381945; 23193290; 19691289; 18988627;
181VHRDVKPSNFLYNRRdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19664994; 16381945; 23193290; 18988627; 22135298; 22817900
277GKDGKEGSVGLSVQRPhosphoSitePlus;curated22135298; 25627689; 20873877
281KEGSVGLSVQRSVFGcurated20873877
296ERNFNIHSSISHESPcurated20873877
297RNFNIHSSISHESPAPhosphoSitePlus;curated22135298; 20873877
299FNIHSSISHESPAVKcurated20873877
302HSSISHESPAVKLMKdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20058876; 16381945; 23193290; 18988627; 22135298; 25627689;
348TASSCPASLTCDCYAcurated19690332
356LTCDCYATDKVCSICcurated19690332
376QVAPRAGTPGFRAPEdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated10846177; 16381945; 23193290; 18988627; 22135298; 22817900
386FRAPEVLTKCPNQTTPhosphoSitePlus22135298
415LSGRYPFYKASDDLTPhosphoSitePlus22135298
472LRGMDSSTPKLTSDIPhosphoSitePlus22135298
484SDIQGHASHQPAISEPhosphoSitePlus22135298
490ASHQPAISEKTDHKAPhosphoSitePlus;curated22135298; 25627689
498EKTDHKASCLVQTPPPhosphoSitePlus22135298
503KASCLVQTPPGQYSGdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19413330; 16381945; 23193290; 18988627; 22135298; 25627689;
508VQTPPGQYSGNSFKKdbPTM 3.0;curated19369195; 16381945; 23193290
Sequence
(Fasta)		MEASLGIQMD EPMAFSPQRD RFQAEGSLKK NEQNFKLAGV KKDIEKLYEA VPQLSNVFKI 60
EDKIGEGTFS SVYLATAQLQ VGPEEKIALK HLIPTSHPIR IAAELQCLTV AGGQDNVMGV 120
KYCFRKNDHV VIAMPYLEHE SFLDILNSLS FQEVREYMLN LFKALKRIHQ FGIVHRDVKP 180
SNFLYNRRLK KYALVDFGLA QGTHDTKIEL LKFVQSEAQQ ERCSQNKSHI ITGNKIPLSG 240
PVPKELDQQS TTKASVKRPY TNAQIQIKQG KDGKEGSVGL SVQRSVFGER NFNIHSSISH 300
ESPAVKLMKQ SKTVDVLSRK LATKKKAIST KVMNSAVMRK TASSCPASLT CDCYATDKVC 360
SICLSRRQQV APRAGTPGFR APEVLTKCPN QTTAIDMWSA GVIFLSLLSG RYPFYKASDD 420
LTALAQIMTI RGSRETIQAA KTFGKSILCS KEVPAQDLRK LCERLRGMDS STPKLTSDIQ 480
GHASHQPAIS EKTDHKASCL VQTPPGQYSG NSFKKGDSNS CEHCFDEYNT NLEGWNEVPD 540
EAYDLLDKLL DLNPASRITA EEALLHPFFK DMSL 575
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF00069--Pkinase
Gene Ontology

GO:0005737--C:cytoplasm
GO:0045171--C:intercellular bridge
GO:0015630--C:microtubule cytoskeleton
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0016301--F:kinase activity
GO:0046872--F:metal ion binding
GO:0004672--F:protein kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0044770--P:cell cycle phase transition
GO:0051301--P:cell division
GO:0006260--P:DNA replication
GO:0006270--P:DNA replication initiation
GO:0000727--P:double-strand break repair via break-induced replication
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0000278--P:mitotic cell cycle
GO:0018105--P:peptidyl-serine phosphorylation
GO:0006909--P:phagocytosis
GO:0008284--P:positive regulation of cell proliferation
GO:0010971--P:positive regulation of G2/M transition of mitotic cell cycle
GO:0010571--P:positive regulation of nuclear cell cycle DNA replication
GO:0008360--P:regulation of cell shape