dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000063
Uniprot Accession O00305; CACB4_HUMAN; A7BJ74; A8K1Y4; B4DG40; O60515; Q6B000; Q96L40;
Genbank Protein ID NP_000717.2; NP_001005746.1; NP_001005747.1; NP_001139270.1;
Genbank Nucleotide ID NM_000726.3; NM_001005746.2; NM_001005747.2; NM_001145798.1;
Protein Name Voltage-dependent L-type calcium channel subunit beta-4
Protein Synonyms/Alias
Gene Name CACNB4
Gene Synonyms/Alias CACNLB4;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Phosphorylation Sites
 dbPAF PTMs: 17
PositionPeptidesSourceReferences ( PMIDs )
11SSYAKNGTADGPHSPPhosphoSitePlus22135298
99PVAFAVKTNVSYCGAdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus18220336; 16381945; 23193290; 22135298
102FAVKTNVSYCGALDEdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus18220336; 16381945; 23193290; 22135298
103AVKTNVSYCGALDEDdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus18220336; 16381945; 23193290; 22135298
180GGKSSGNSSSSLGEMPhosphoSitePlus22135298
182KSSGNSSSSLGEMVSPhosphoSitePlus22135298
183SSGNSSSSLGEMVSGPhosphoSitePlus22135298
213VTEHIPPYDVVPSMRPhosphoSitePlus22135298
218PPYDVVPSMRPVVLVPhosphoSitePlus22135298
421LGRNLGSTALSPYPTPhosphoSitePlus22135298
435TAISGLQSQRMRHSNPhosphoSitePlus22135298
476KSRNRLSSSSQHSRDPhosphoSitePlus22135298
477SRNRLSSSSQHSRDHPhosphoSitePlus22135298
481LSSSSQHSRDHYPLVPhosphoSitePlus22135298
499YPDSYQDTYKPHRNRPhosphoSitePlus22135298
500PDSYQDTYKPHRNRGPhosphoSitePlus22135298
512NRGSPGGYSHDSRHRPhosphoSitePlus22135298
Sequence
(Fasta)		MSSSSYAKNG TADGPHSPTS QVARGTTTRR SRLKRSDGST TSTSFILRQG SADSYTSRPS 60
DSDVSLEEDR EAIRQEREQQ AAIQLERAKS KPVAFAVKTN VSYCGALDED VPVPSTAISF 120
DAKDFLHIKE KYNNDWWIGR LVKEGCEIGF IPSPLRLENI RIQQEQKRGR FHGGKSSGNS 180
SSSLGEMVSG TFRATPTSTA KQKQKVTEHI PPYDVVPSMR PVVLVGPSLK GYEVTDMMQK 240
ALFDFLKHRF DGRISITRVT ADISLAKRSV LNNPSKRAII ERSNTRSSLA EVQSEIERIF 300
ELARSLQLVV LDADTINHPA QLIKTSLAPI IVHVKVSSPK VLQRLIKSRG KSQSKHLNVQ 360
LVAADKLAQC PPEMFDVILD ENQLEDACEH LGEYLEAYWR ATHTTSSTPM TPLLGRNLGS 420
TALSPYPTAI SGLQSQRMRH SNHSTENSPI ERRSLMTSDE NYHNERARKS RNRLSSSSQH 480
SRDHYPLVEE DYPDSYQDTY KPHRNRGSPG GYSHDSRHRL 521
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0106--Calcium
KW-0107--Calcium channel
KW-0109--Calcium transport
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0887--Epilepsy
KW-0407--Ion channel
KW-0406--Ion transport
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0813--Transport
KW-0851--Voltage-gated channel
Interpro

IPR008145--GK/Ca_channel_bsu
IPR027417--P-loop_NTPase
IPR001452--SH3_domain
IPR000584--VDCC_L_bsu
PROSITE

PS50002--SH3
Pfam

PF00625--Guanylate_kin
PF12052--VGCC_beta4Aa_N
Gene Ontology

GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005886--C:plasma membrane
GO:0045202--C:synapse
GO:0005891--C:voltage-gated calcium channel complex
GO:0005245--F:voltage-gated calcium channel activity
GO:0007628--P:adult walking behavior
GO:0007411--P:axon guidance
GO:0070588--P:calcium ion transmembrane transport
GO:0046058--P:cAMP metabolic process
GO:0006874--P:cellular calcium ion homeostasis
GO:0050908--P:detection of light stimulus involved in visual perception
GO:0014051--P:gamma-aminobutyric acid secretion
GO:0007214--P:gamma-aminobutyric acid signaling pathway
GO:0051899--P:membrane depolarization
GO:0048747--P:muscle fiber development
GO:0007528--P:neuromuscular junction development
GO:0019227--P:neuronal action potential propagation
GO:0048541--P:Peyer's patch development
GO:1901385--P:regulation of voltage-gated calcium channel activity
GO:0048536--P:spleen development
GO:0007268--P:synaptic transmission
GO:0035249--P:synaptic transmission, glutamatergic
GO:0050852--P:T cell receptor signaling pathway
GO:0048538--P:thymus development
GO:0006810--P:transport