dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000062
Uniprot Accession O00303; EIF3F_HUMAN; A8K0S2; Q6IB45; Q8N978;
Genbank Protein ID NP_003745.1;
Genbank Nucleotide ID NM_003754.2;
Protein Name Eukaryotic translation initiation factor 3 subunit F
Protein Synonyms/Alias
Gene Name EIF3F
Gene Synonyms/Alias EIF3S5;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Phosphorylation Sites
 dbPAF PTMs: 13
PositionPeptidesSourceReferences ( PMIDs )
46PAAAPASSSDPAAAAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated12446680; 16381945; 23193290; 19245811; 18988627; 22135298;
105ILASIVDSYERRNEGPhosphoSitePlus22135298
119GAARVIGTLLGTVDKdbPTM 3.0;PhosphoSitePlus;curated19245811; 16381945; 23193290; 22135298; 22817900
142FSVPHNESEDEVAVDPhosphoSitePlus;curated22135298; 25627689
216GRMSIKAYVSTLMGVdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
219SIKAYVSTLMGVPGRPHOSIDA21081558
233RTMGVMFTPLTVKYAPhosphoSitePlus22135298
241PLTVKYAYYDTERIGPhosphoSitePlus;curated22135298; 22817900
255GVDLIMKTCFSPNRVdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated18669648; 16381945; 23193290; 22115753; 20068231; 18988627;
258LIMKTCFSPNRVIGLdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated17322308; 18669648; 16381945; 23193290; 20068231; 20363803;
266PNRVIGLSSDLQQVGPhosphoSitePlus22135298
267NRVIGLSSDLQQVGGPhosphoSitePlus22135298
295QYAEDVLSGKVSADNPHOSIDA21081558
Sequence
(Fasta)		MATPAVPVSA PPATPTPVPA AAPASVPAPT PAPAAAPVPA AAPASSSDPA AAAAATAAPG 60
QTPASAQAPA QTPAPALPGP ALPGPFPGGR VVRLHPVILA SIVDSYERRN EGAARVIGTL 120
LGTVDKHSVE VTNCFSVPHN ESEDEVAVDM EFAKNMYELH KKVSPNELIL GWYATGHDIT 180
EHSVLIHEYY SREAPNPIHL TVDTSLQNGR MSIKAYVSTL MGVPGRTMGV MFTPLTVKYA 240
YYDTERIGVD LIMKTCFSPN RVIGLSSDLQ QVGGASARIQ DALSTVLQYA EDVLSGKVSA 300
DNTVGRFLMS LVNQVPKIVP DDFETMLNSN INDLLMVTYL ANLTQSQIAL NEKLVNL 358
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR027531--eIF3f
IPR000555--JAMM/MPN+_dom
IPR024969--Rpn11/EIF3F_C
PROSITE
Pfam

PF01398--JAB
PF13012--MitMem_reg
Gene Ontology

GO:0005829--C:cytosol
GO:0016282--C:eukaryotic 43S preinitiation complex
GO:0033290--C:eukaryotic 48S preinitiation complex
GO:0005852--C:eukaryotic translation initiation factor 3 complex
GO:0071541--C:eukaryotic translation initiation factor 3 complex, eIF3m
GO:0016020--C:membrane
GO:0003743--F:translation initiation factor activity
GO:0031369--F:translation initiation factor binding
GO:0004843--F:ubiquitin-specific protease activity
GO:0044267--P:cellular protein metabolic process
GO:0001731--P:formation of translation preinitiation complex
GO:0010467--P:gene expression
GO:0016579--P:protein deubiquitination
GO:0006446--P:regulation of translational initiation
GO:0006412--P:translation
GO:0006413--P:translational initiation