| Tag |
Content |
| dbPAF ID |
dbPAF-0000061 |
| Uniprot Accession |
O00300; TR11B_HUMAN; B2R9A8; O60236; Q53FX6; Q9UHP4;
|
| Genbank Protein ID |
NP_002537.3;
|
| Genbank Nucleotide ID |
NM_002546.3;
|
| Protein Name |
Tumor necrosis factor receptor superfamily member 11B |
| Protein Synonyms/Alias |
Osteoclastogenesis inhibitory factor;Osteoprotegerin; |
| Gene Name |
TNFRSF11B |
| Gene Synonyms/Alias |
OCIF;OPG; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.Functional Description
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MNNLLCCALV FLDISIKWTT QETFPPKYLH YDEETSHQLL CDKCPPGTYL KQHCTAKWKT 60
VCAPCPDHYY TDSWHTSDEC LYCSPVCKEL QYVKQECNRT HNRVCECKEG RYLEIEFCLK 120
HRSCPPGFGV VQAGTPERNT VCKRCPDGFF SNETSSKAPC RKHTNCSVFG LLLTQKGNAT 180
HDNICSGNSE STQKCGIDVT LCEEAFFRFA VPTKFTPNWL SVLVDNLPGT KVNAESVERI 240
KRQHSSQEQT FQLLKLWKHQ NKDQDIVKKI IQDIDLCENS VQRHIGHANL TFEQLRSLME 300
SLPGKKVGAE DIEKTIKACK PSDQILKLLS LWRIKNGDQD TLKGLMHALK HSKTYHFPKT 360
VTQSLKKTIR FLHSFTMYKL YQKLFLEMIG NQVQSVKISC L
402Fasta Sequence
>O00300|TNFRSF11B|Homo sapiens(Human)
MNNLLCCALVFLDISIKWTTQETFPPKYLHYDEETSHQLLCDKCPPGTYLKQHCTAKWKTVCAPCPDHYYTDSWHTSDECLYCSPVCKELQYVKQECNRTHNRVCECKEGRYLEIEFCLKHRSCPPGFGVVQAGTPERNTVCKRCPDGFFSNETSSKAPCRKHTNCSVFGLLLTQKGNATHDNICSGNSESTQKCGIDVTLCEEAFFRFAVPTKFTPNWLSVLVDNLPGTKVNAESVERIKRQHSSQEQTFQLLKLWKHQNKDQDIVKKIIQDIDLCENSVQRHIGHANLTFEQLRSLMESLPGKKVGAEDIEKTIKACKPSDQILKLLSLWRIKNGDQDTLKGLMHALKHSKTYHFPKTVTQSLKKTIRFLHSFTMYKLYQKLFLEMIGNQVQSVKISCL
|
| Keyword |
KW-0002--3D-structure
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0732--Signal
|
| Interpro |
IPR011029--DEATH-like_dom
IPR000488--Death_domain
IPR001368--TNFR/NGFR_Cys_rich_reg
IPR022323--TNFR_11
IPR017371--TNFR_11B
|
| PROSITE |
PS00652--TNFR_NGFR_1
PS50050--TNFR_NGFR_2
|
| Pfam |
PF00531--Death
PF00020--TNFR_c6
|
| Gene Ontology |
GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0005578--C:proteinaceous extracellular matrix
GO:0005125--F:cytokine activity
GO:0004872--F:receptor activity
GO:0005031--F:tumor necrosis factor-activated receptor activity
GO:0097190--P:apoptotic signaling pathway
GO:0030198--P:extracellular matrix organization
GO:0006955--P:immune response
GO:0006954--P:inflammatory response
GO:0045779--P:negative regulation of bone resorption
GO:0042489--P:negative regulation of odontogenesis of dentin-containing tooth
GO:0043410--P:positive regulation of MAPK cascade
GO:0042981--P:regulation of apoptotic process
GO:0042127--P:regulation of cell proliferation
GO:0046685--P:response to arsenic-containing substance
GO:0042493--P:response to drug
GO:0043627--P:response to estrogen
GO:0032496--P:response to lipopolysaccharide
GO:0032026--P:response to magnesium ion
GO:0007584--P:response to nutrient
GO:0007165--P:signal transduction
GO:0001501--P:skeletal system development
GO:0033209--P:tumor necrosis factor-mediated signaling pathway
|
