dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000060
Uniprot Accession O00299; CLIC1_HUMAN; Q15089; Q502X1;
Genbank Protein ID NP_001274522.1; NP_001274523.1; NP_001279.2;
Genbank Nucleotide ID NM_001287593.1; NM_001287594.1; NM_001288.4;
Protein Name Chloride intracellular channel protein 1
Protein Synonyms/Alias Chloride channel ABP;Nuclear chloride ion channel 27;NCC27;Regulatory nuclear chloride ion channel protein;hRNCC;
Gene Name CLIC1
Gene Synonyms/Alias G6;NCC27;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
48FNVTTVDTKRRTETVPhosphoSitePlus;curated22135298; 23917254
52TVDTKRRTETVQKLCPHOSIDA21081558
103LAALNPESNTAGLDIPhosphoSitePlus;curated22135298; 22817900
115LDIFAKFSAYIKNSNcurated23911959
121FSAYIKNSNPALNDNPhosphoSitePlus;curated22135298; 25627689; 23917254; 22199227; 20873877
146VLDNYLTSPLPEEVDPhosphoSitePlus;curated22135298; 23186163; 24961811
155LPEEVDETSAEDEGVcurated25627689; 23898821; 20873877
156PEEVDETSAEDEGVSPhosphoSitePlus;curated22135298; 25627689; 23917254; 20873877
163SAEDEGVSQRKFLDGdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated18077418; 16381945; 23193290; 18988627; 22135298; 25627689;
198CKKYRGFTIPEAFRGPhosphoSitePlus22135298
211RGVHRYLSNAYAREEPhosphoSitePlus;curated22135298; 23917254; 20873877
221YAREEFASTCPDDEEcurated20873877
222AREEFASTCPDDEEIPhosphoSitePlus;curated22135298; 20873877
233DEEIELAYEQVAKALdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated20562096; 16381945; 23193290; 19060867; 22135298; 22817900
Sequence
(Fasta)		MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR RTETVQKLCP 60
GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN PESNTAGLDI FAKFSAYIKN 120
SNPALNDNLE KGLLKALKVL DNYLTSPLPE EVDETSAEDE GVSQRKFLDG NELTLADCNL 180
LPKLHIVQVV CKKYRGFTIP EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL 240
K 242
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-1003--Cell membrane
KW-0868--Chloride
KW-0869--Chloride channel
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0318--Glutathionylation
KW-0407--Ion channel
KW-0406--Ion transport
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
KW-0851--Voltage-gated channel
Interpro

IPR002946--CLIC
IPR030259--CLIC-1
IPR010987--Glutathione-S-Trfase_C-like
IPR004045--Glutathione_S-Trfase_N
IPR012336--Thioredoxin-like_fold
PROSITE

PS50405--GST_CTER
Pfam

PF13417--GST_N_3
Gene Ontology

GO:0072562--C:blood microparticle
GO:0005903--C:brush border
GO:0034707--C:chloride channel complex
GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0016020--C:membrane
GO:0005739--C:mitochondrion
GO:0005635--C:nuclear envelope
GO:0031965--C:nuclear membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0031982--C:vesicle
GO:0005254--F:chloride channel activity
GO:0005244--F:voltage-gated ion channel activity
GO:1902476--P:chloride transmembrane transport
GO:0006821--P:chloride transport
GO:0070527--P:platelet aggregation
GO:0045669--P:positive regulation of osteoblast differentiation
GO:0051881--P:regulation of mitochondrial membrane potential
GO:0007165--P:signal transduction